Sign in

Alessandro Romanel

@aromanel.bsky.social
13 followers 8 following 2 posts

Head of the Bioinformatics and Computational Genomics Lab, CIBIO, University of Trento.

PostsRepliesMedia
Alessandro Romanel @aromanel.bsky.social · 25/11/2025
🚨 Out in NAR @narjournal.bsky.social! Introducing HapScoreDB: a database of protein language model functional scores for haplotype-resolved protein sequences. 📄 Paper: doi.org/10.1093/nar/... 💻 DB: bcglab.cibio.unitn.it/hapscoredb #Bioinformatics #Genomics #ProteinLanguageModels #CompBio
doi.org
HapScoreDB: a database of protein language model functional scores for haplotype-resolved protein sequences
Abstract. Deciphering the functional effects of genetic variants, especially those inherited together on the same haplotype, remains a major challenge in h
162
Reposted by Alessandro Romanel
Francesco Cambuli @francesco-cambuli.bsky.social · 04/12/2024
Our latest collaborative project co-led by Dario De Felice, Alessandro Alaimo, @bresdavide.bsky.social, and Andrea Lunardi at CIBIO UniTrento 🔬 🧫 🧬 We generated pro-luminal prostate organoid models and found that common FOXA1 cancer indels are loss-of-function www.embopress.org/doi/full/10....
embopress.org
Rarγ-Foxa1 signaling promotes luminal identity in prostate progenitors and is disrupted in prostate cancer | EMBO reports
imageimageLeveraging mouse adult prostate organoids reveals regulators of prostatic luminal lineage commitment. The androgen pathway together with retinoic acid/Rarγ/Foxa1 signaling programs luminal p...
053
Reposted by Alessandro Romanel
Davide Bressan @bresdavide.bsky.social · 24/01/2025
Are you looking for a tool to analyze ChIP-seq data with spike-in control? Check out SpikeFlow 👇 academic.oup.com/nargab/artic...
academic.oup.com
SpikeFlow: automated and flexible analysis of ChIP-Seq data with spike-in control
Abstract. ChIP with reference exogenous genome (ChIP-Rx) is widely used to study histone modification changes across different biological conditions. A key
031