Can epigenetic evolution create targetable dependencies in colorectal cancer? Our preprint combines single-cell multi-omics and patient-derived organoids to identify recurrent chromatin changes across primary and metastatic CRC. 🧬
www.biorxiv.org/content/10.6...
biorxiv.org
Epigenetic evolution of colorectal cancer and its microenvironment reveals new vulnerabilities
Epigenetics is central to tumorigenesis, but the co-evolution of the cancer epigenome and its microenvironment is severely understudied. Here, we measure chromatin accessibility and transcriptome, at ...
