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Reposted by Aoon Rizvi

SpruijtLab @spruijtlab.bsky.social · 16/07/2025

New in JACS! Using NMR, we show how condensates selectively bind and localize ions following the 'law of matching water affinities', shaping condensate composition, interface potential & RNA stability. Read about it here: doi.org/10.1021/jacs.5c07295 @irissmokers.bsky.social

doi.org

Selective Ion Binding and Uptake Shape the Microenvironment of Biomolecular Condensates

Biomolecular condensates modulate various ion-dependent cellular processes and can regulate subcellular ion distributions by selective uptake of ions. To understand these processes, it is essential to...

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Steve Zimmerman @steveczimmerman.bsky.social · 21/05/2025

My last three students at Illinois. Congratulations to Dr. Joel Roberts, Dr. Nafisa Ibrahim (co-advised by @jrl-electrochem.bsky.social), and Astarte Abbott. Three amazing students with a bright careers ahead!

Prof Steve Zimmerman in black cap and gown flanked by three students in blue cap and gowns standing in front of red brick building. All three graduates are holding their diplomas.

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Kalli Kappel @kallikappel.bsky.social · 17/06/2025

In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput approach to measure nuclear condensate formation, and applied it to ~14,000 IDPs to find out! rdcu.be/eq975

rdcu.be

Characterizing protein sequence determinants of nuclear condensates by high-throughput pooled imaging with CondenSeq

Nature Methods - CondenSeq is an imaging-based, high-throughput platform for characterizing condensate formation within the nuclear environment, uncovering the protein sequence features that...

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Harmit Singh Malik @harmitmalik.bsky.social · 08/06/2025

(Longish thread. Apologies) I have met many inspiring colleagues over the past few months, many of whom are in academic institutions targeted by the current administration, and many others who are about to be (the analogy to the ‘eye of Sauron’ has been invoked many times; gallows humor). 1/

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Rosana Collepardo @rcollepardo.bsky.social · 11/02/2025

Introducing Mpipi-Recharged🔥🔥🔥 Our Mpipi coarse-grained model for biomolecular condensates now includes a pair-specific electrostatic potential that improves its predictions, including for challenging charged systems—all while still treating solvent and ions implicitly pubs.acs.org/doi/10.1021/...

pubs.acs.org

Chemically Informed Coarse-Graining of Electrostatic Forces in Charge-Rich Biomolecular Condensates

Biomolecular condensates composed of highly charged biomolecules, such as DNA, RNA, chromatin, and nucleic-acid binding proteins, are ubiquitous in the cell nucleus. The biophysical properties of thes...

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Keren Lasker @kerenlasker.bsky.social · 30/12/2024

1/ 🚨We’re thrilled to share our latest study: "Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟 www.biorxiv.org/content/10.1... How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️

biorxiv.org

Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure

Biomolecular condensates play key roles in the spatiotemporal regulation of cellular processes. Yet, the relationship between atomic features and condensate function remains poorly understood. We stud...

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Aoon Rizvi @aoonr.bsky.social · 04/12/2024

Hello science bluesky! Excited to be part of The Rising Stars in Soft and Biological Matter Symposium along with so many amazing scientists! Register here to attend this virtual symposium next week! mrsec.uchicago.edu/educational-...

mrsec.uchicago.edu

Rising Stars symposium

The Rising Stars in Soft and Biological Matter Symposium, co-sponsored by UChicago and the University of California San Diego MRSECs, provides a platform for exceptional early-career soft and biologic...

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