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Alexander Kwakye

@alexrepgh.bsky.social
27 followers 61 following 5 posts

I’m a postdoc in the Pool Lab at UW Madison. I am broadly interested in molecular mechanisms of rapid adaptation and human diseases.

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Reposted by Alexander Kwakye
Nature Ecology & Evolution @natecoevo.nature.com · 28/09/2026
Species persistence following hybridization in nature requires the purging of introgressed alleles. Genomic monitoring of a tsunami-induced hybrid stickleback population in Japan reveals rapid genome-wide purging including of loci involved in reproductive isolation 🧪 www.nature.com/articles/s41...
nature.com
Rapid genome-wide purging following tsunami-induced hybridization in a stickleback population - Nature Ecology & Evolution
Species persistence following hybridization in nature requires the purging of introgressed alleles. Genomic monitoring of a tsunami-induced hybrid stickleback population in Japan reveals rapid genome-...
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Reposted by Alexander Kwakye
Nature Ecology & Evolution @natecoevo.nature.com · 30/09/2026
A tsunami of genome reshuffling www.nature.com/articles/s41... Kelsie Hunnicutt discusses a new study in hybrid sticklebacks showing that hybrid incompatibilities drive rapid removal of introgressed alleles following the 2011 Tohoku tsunami in Japan Free to read: rdcu.be/ekJrEHm2iUea
nature.com
A tsunami of genome reshuffling - Nature Ecology & Evolution
Generation-by-generation ancestry tracking in hybrid stickleback shows that hybrid incompatibilities drive rapid removal of introgressed alleles following a tsunami.
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Reposted by Alexander Kwakye
Genome Biology and Evolution @genomebiolevol.bsky.social · 22/09/2026
@alexrepgh.bsky.social et al. identify SNP associated with genes involved in physiological processes such as ion regulation in gills and fatty acid metabolism in the brain during freshwater adaptation by oceanic sticklebacks. 🔗 academic.oup.com/gbe/article/... #societyjournal #genome #evolution
academic.oup.com
Genomic Signatures of Selection Are Enriched in Differentially Expressed Genes in Sticklebacks Adapting to Contrasting Environments
Abstract. Whole genome scans have identified numerous adaptive alleles in many species; however, linking these alleles to specific phenotypes remains a maj
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Reposted by Alexander Kwakye
Stickleback Stock Center at UConn @sticklestock.bsky.social · 18/09/2026
Disentangling unique site-specific and shared habitat-level adaptation in a classic system of repeated evolution— just dropped this month! Read about your favorite “classic system of repeated evolution” ye ole stickleback! www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Alexander Kwakye @alexrepgh.bsky.social · 17/09/2026
Part of my PhD work is now published in @genomebiolevol.bsky.social academic.oup.com/gbe/article/...
academic.oup.com
Genomic Signatures of Selection Are Enriched in Differentially Expressed Genes in Sticklebacks Adapting to Contrasting Environments
Abstract. Whole genome scans have identified numerous adaptive alleles in many species; however, linking these alleles to specific phenotypes remains a maj
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Reposted by Alexander Kwakye
Windsor Aguirre @windsor-aguirre.bsky.social · 03/08/2026
In case you missed it, looks like a very interesting paper: Rare jackpot individuals drive rapid adaptation in Threespine Stickleback www.nature.com/articles/s41...
nature.com
Rare jackpot individuals drive rapid adaptation in Threespine Stickleback - Nature Communications
Recombination can speed up adaptation by bringing beneficial alleles together. However, this study shows rapid adaptation in Threespine Stickleback fish depends more on the initial frequency of allele...
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Reposted by Alexander Kwakye
john-pool.bsky.social @john-pool.bsky.social · 11/06/2026
So good to be at #PEQG26 ! * Congrats to PhD student @siyuan-feng.bsky.social on giving 2 talks (DNA->music and evol. multi-omics) within ~16 hours! * Look for posters by Jamie Freeman and Myron Child. * Searching for a postdoc! Glad to talk here at PEQG, online, or later this month at #SMBE2026
bsky.app
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Reposted by Alexander Kwakye
bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 31/05/2026
Variable jackpot individuals provide most alleles for repeated, rapid adaptation to freshwater by anadromous Threespine Stickleback www.biorxiv.org/content/10.64898/20…
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Reposted by Alexander Kwakye
Andy Foote @andrewfoote.bsky.social · 16/04/2026
Complex Patterns of Hitchhiking Mutation Load Among Stickleback Populations. New paper led by Jana Nickel out in GBE @genomebiolevol.bsky.social doi.org/10.1093/gbe/...
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Reposted by Alexander Kwakye
bioRxivpreprint @biorxivpreprint.bsky.social · 23/02/2026
Genomic signatures of selection are enriched in differentially expressed genes in sticklebacks adapting to contrasting environments www.biorxiv.org/content/10.64898/20…
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Reposted by Alexander Kwakye
bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 23/02/2026
Genomic signatures of selection are enriched in differentially expressed genes in sticklebacks adapting to contrasting environments www.biorxiv.org/content/10.64898/20…
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Reposted by Alexander Kwakye
Andy Foote @andrewfoote.bsky.social · 28/10/2025
New paper out in Heredity: 'Evidence of long-term purging of mutation burden in killer whale genomes'. Time calibration of purging was through inclusion of an ancient (7.5Kyr) genome which was close to directly ancestral to the present-day population with signature of purging. rdcu.be/eM25j
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Reposted by Alexander Kwakye
bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 16/10/2025
Experimental rewilding of stickleback drives phenotypic shifts that oppose long-term evolutionary trajectories in Daphnia in Alaskan lakes www.biorxiv.org/content/10.1101/202…
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Reposted by Alexander Kwakye
bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 16/10/2025
Transposable elements drive much of naturally occurring genetic lethality in Drosophila melanogaster www.biorxiv.org/content/10.1101/202…
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Reposted by Alexander Kwakye
Andy Foote @andrewfoote.bsky.social · 15/08/2025
'Ancient stickleback genomes reveal the early stages of parallel adaptation' - now published online in Evolution @journal-evo.bsky.social‬
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Reposted by Alexander Kwakye
bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 18/04/2025
Ancient stickleback genomes reveal the chronology of parallel adaptation www.biorxiv.org/content/10.1101/202…
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Reposted by Alexander Kwakye
bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 26/03/2025
Rare Jackpot Individuals Drive Rapid Adaptation in Threespine Stickleback www.biorxiv.org/content/10.1101/202…
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Reposted by Alexander Kwakye
bioRxivpreprint @biorxivpreprint.bsky.social · 26/03/2025
Rare Jackpot Individuals Drive Rapid Adaptation in Threespine Stickleback www.biorxiv.org/content/10.1101/202…
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Reposted by Alexander Kwakye
bioRxiv Genetics @biorxiv-genetic.bsky.social · 03/03/2025
Clinical progression of clonal hematopoiesis is determined by a combination of mutation timing, fitness, and clonal structure www.biorxiv.org/content/10.1101/202…
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Reposted by Alexander Kwakye
bioRxiv Genetics @biorxiv-genetic.bsky.social · 01/03/2025
Blood-based Epigenetic Instability Linked to Human Aging and Disease www.biorxiv.org/content/10.1101/202…
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Reposted by Alexander Kwakye
bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 01/03/2025
Tracing the Spread of Celtic Languages using Ancient Genomics www.biorxiv.org/content/10.1101/202…
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Reposted by Alexander Kwakye
bioRxiv Genetics @biorxiv-genetic.bsky.social · 30/12/2024
Coancestry superposed on admixed populations yields measures of relatedness at individual-level resolution www.biorxiv.org/content/10.1101/202…
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Reposted by Alexander Kwakye
Science Magazine @science.org · 25/02/2025
Tomatoes lose their bitterness and toxicity as they ripen thanks to DNA demethylation, the hormone ethylene, and key transcription factors, finds a new #ScienceAdvances study. scim.ag/4bfdr8u
scim.ag
Removal of toxic steroidal glycoalkaloids and bitterness in tomato is controlled by a complex epigenetic and genetic network
A complex regulatory network controls the removal of toxic steroidal glycoalkaloids during tomato ripening.
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Reposted by Alexander Kwakye
bioRxivpreprint @biorxivpreprint.bsky.social · 27/02/2025
Estimating gene conversion rates from population data using multi-individual identity by descent www.biorxiv.org/content/10.1101/202…
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Reposted by Alexander Kwakye
bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 28/02/2025
Accelerated genome shuffling associated with rapid evolution of sexual conflict in seed beetles www.biorxiv.org/content/10.1101/202…
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Reposted by Alexander Kwakye
bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 28/02/2025
Local Adaptation of Life-History Traits in a Seasonal Environment www.biorxiv.org/content/10.1101/202…
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Reposted by Alexander Kwakye
bioRxivpreprint @biorxivpreprint.bsky.social · 28/02/2025
Not just mutations: Inbreeding depression persists without genetic variation www.biorxiv.org/content/10.1101/202…
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Reposted by Alexander Kwakye
bioRxiv Genomics @biorxiv-genomic.bsky.social · 08/01/2025
Variant effects depend on polygenic background: experimental, clinical, and evolutionary implications www.biorxiv.org/content/10.1101/202…
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Reposted by Alexander Kwakye
bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 07/01/2025
Viral Simulation Reveals Overestimation Bias in Within-Host Phylodynamic Migration Rate Estimates Under Selection www.biorxiv.org/content/10.1101/202…
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Alexander Kwakye @alexrepgh.bsky.social · 01/01/2025
Happy new year 🎆
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Alexander Kwakye @alexrepgh.bsky.social · 31/12/2024
I wish Zach Bryan’s Bathwater was much longer. What a beautiful song.
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Alexander Kwakye @alexrepgh.bsky.social · 31/12/2024
I’ve learned to be measured in all my dealings. It’s helped me to avoid a lot of unnecessary altercations.
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