Aspergillus oryzae was engineered to produce high levels of geranylgeranyldiphosphate (GGPP) and ent-kaurene, via ent-copalyl diphosphate, as precursors for future metabolic engineering projects via t...

Despite the significance of nicotine, a neuroactive alkaloid produced by tobacco, its biosynthesis has remained elusive. Here, the authors report the in vitro and in planta reconstruction of a fo...

An alkyl citrate biosynthetic gene cluster (ctr) was identified from 47 members of the fungal family of Hypoxylaceae by genome mining. The Hypomontagnella monticulosa MUCL 54604 ctr cluster was deploy...

Gibberellins are structurally complex diterpenoid plant hormones with widespread agricultural applications. However, of the 136 known congeners found in nature, very few are easily accessible, prevent...

Gibberellins are structurally complex diterpenoid plant hormones with widespread agricultural applications. However, of the 136 known congeners found in nature, very few are easily accessible, prevent...

The biosynthetic pathway for dimeric cyclotryptamine alkaloids—(−)-chimonanthine, meso-chimonanthine, (−)-folicanthine and (+)-sinodamine B—has been reported in Calycanthaceae plants. The pathway feat...

Gibberellins are structurally complex diterpenoid plant hormones with widespread agricultural applications. However, of the 136 known congeners found in nature, very few are easily accessible, prevent...

Gibberellins are structurally complex diterpenoid plant hormones with widespread agricultural applications. However, of the 136 known congeners found in nature, very few are easily accessible, prevent...

Nature Communications - Withanolides are plant steroids with potent bioactivities found in many medicinal plants including Withania somnifera, but their biosynthetic pathway is largely unknown....

Triterpenoids and steroids are structurally complex polycyclic natural products with potent biological functions, for example, as hormones. In all eukaryotes, the carbon skeletons of these compounds a...