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SattelyLab

@sattelylab.bsky.social
171 followers 41 following 19 posts

Website: www.sattelylab.org Member-run account of the Elizabeth Sattely Lab at Stanford University Plant natural products | Plant-microbe interactions | Plant chemistry | Pathway discovery | Plant health | Plant-human interactions

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SattelyLab @sattelylab.bsky.social · 09/07/2026
Great work by Yaereen and Kevin from the lab! Have a look at the unusual biosynthesis of anti-cancer agent homoharringtonine #plants #biosynthesis #anti-cancer #natchembio
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Plant Science Spotlight @plant-sci.bsky.social · 01/06/2026
🌿🧬 Taxol pathway mapped with new method mpXsn. Seventeen genes known, eight newly discovered. Baccatin III produced in tobacco at natural levels. Breakthrough for anti-cancer drug production. #plantscience @cmcclune.bsky.social @sattelylab.bsky.social @nature.com www.nature.com/articles/s41...
nature.com
Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III - Nature
An approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose curren...
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Nature Biotechnology @natbiotech.nature.com · 06/05/2026
Research Briefing: A PIVOT towards single-cell functional genetic screening in plants www.nature.com/articles/s41...
nature.com
A PIVOT towards single-cell functional genetic screening in plants - Nature Biotechnology
We developed PIVOT, a single-cell screening platform for functional characterization of plant genes. PIVOT enables delivery of gene libraries to tobacco leaves with single multiplicity of infection an...
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Nature Biotechnology @natbiotech.nature.com · 05/05/2026
A single-cell screening platform accelerates functional genetics in plants - @sattelylab.bsky.social go.nature.com/4n8wzLv
go.nature.com
A single-cell screening platform accelerates functional genetics in plants - Nature Biotechnology
A pooled, cell-based, genetic screening platform in plants is used for the functional analysis of cytokinin signaling proteins.
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SattelyLab @sattelylab.bsky.social · 12/03/2026
Celebrating the newest paper from the Sattely lab, Kazuki Nagashima's lab, and @jamieblum.bsky.social's lab! news.stanford.edu/stories/2026...
news.stanford.edu
Why can some people eat food that others are allergic to?
Research shows how regulatory T cells recognize safe foods by scanning for specific protein signals, opening new paths to prevent and treat food allergies.
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Waggoner Lab @labwaggoner.bsky.social · 06/03/2026
Immunodominant epitopes from seed storage proteins are a target of intestinal regulatory T cells that modulate immune challenge to food @sciimmunology.bsky.social www.science.org/doi/10.1126/... @sattelylab.bsky.social @stanforduniversity.bsky.social
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Conor McClune @cmcclune.bsky.social · 18/02/2026
Lovely C&EN @cenmag.bsky.social story on the history and personal impact of the cancer drug Taxol. After spending recent years deciphering how yew trees, our source for Taxol, synthesize this lifesaving drug, it’s so nice to see it in the larger context #secmet #medsky Plants are amazing chemists.
cen.acs.org
Paclitaxel saved my life. New discoveries could boost supply
After decades, scientists have finally pieced together the 23-step biosynthetic pathway to produce this cancer drug
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Tatsuya Nobori @tatsuyanobori.bsky.social · 18/12/2025
It was a wonderful meeting - one of my highlights of 2025. Thank you to the organizers: @sattelylab.bsky.social, @beckybart.bsky.social, and Cyril Zipfel
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SattelyLab @sattelylab.bsky.social · 03/11/2025
We are live! Check out our new website and learn about the research, the people, and the publications of the Sattely Lab www.sattelylab.org
sattelylab.org
Sattely Research Group @ Stanford
Explore plant chemistry research at Sattely Group, focusing on plant chemistry for agriculture and human health innovations.
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rnett42.bsky.social @rnett42.bsky.social · 15/09/2025
Thanks to Dr. Cassandra Quave for hosting me on her Foodie Pharmacology podcast! We discussed the molecules responsible for the properties of medicinal plants - and how my lab studies the chemistry that plants use to make them. Check it out! t.co/nEdpoyN8QD
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SattelyLab @sattelylab.bsky.social · 02/09/2025
Beautiful work by Yaereen and former lab member Kevin! Learn more about the anti-cancer compound homoharringtonine and its'biosynthesis in plants here 🌿https://www.biorxiv.org/content/10.1101/2025.08.26.672243v1
biorxiv.org
Discovery of homoharringtonine pathway enzymes reveals a whole plant model for coordinated biosynthesis
Plants have evolved to produce diverse molecules that inhibit protein translation. A lead example is homoharringtonine (HHT), both a key tool for ribosomal profiling and an FDA-approved treatment for ...
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SattelyLab @sattelylab.bsky.social · 29/08/2025
Congrats Guillermo! Fantastic finish to his ChemE REU program participation
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SattelyLab @sattelylab.bsky.social · 22/08/2025
Congrats, Jack, for a successful PhD defense🎉Party, T-shirt exchange, and a self-made Piñata
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SattelyLab @sattelylab.bsky.social · 21/08/2025
Most recent group photos! So many celebrations🥳
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SattelyLab @sattelylab.bsky.social · 07/08/2025
Couldn't have said it better! Great job @taralowensohn.bsky.social, Will, and Chun! Special thanks to the Gao lab at @stanford.edu #singlecell #plantbiology
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SattelyLab @sattelylab.bsky.social · 07/08/2025
@cmcclune.bsky.social will be at the GRC for Single-Cell Approaches in Plant Biology! Be on the lookout for his talk on Wednesday (8/13) at 9.10 am. Talk will be about some new approaches and discoveries recently published in Nature! www.nature.com/articles/s41... #grc #singlecell #plantbiology
nature.com
Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III - Nature
An approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose curren...
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SattelyLab @sattelylab.bsky.social · 07/08/2025
Watch out for @taralowensohn.bsky.social at the GRC for Single-Cell Approaches in Plant Biology. She will be giving a talk about the pooled gene perturbation and protoplast sorting technologies developed in the lab. Interested? Talk on Monday at 8.10 pm. #grc #singlecell #plants #plantbiology
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jamieblum.bsky.social @jamieblum.bsky.social · 23/07/2025
The Blum lab is recruiting graduate students and postdocs! Grad students: Reach out to me if you're interested in a rotation! Postdoc candidates: recruiting2.ultipro.com/SAL1013SIBS/...
recruiting2.ultipro.com
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SattelyLab @sattelylab.bsky.social · 10/07/2025
Congrats!
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Conor McClune @cmcclune.bsky.social · 02/07/2025
Pithy coverage by @plantaeofficial.bsky.social of our recent Taxol work #chemsky #medsky
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Conor McClune @cmcclune.bsky.social · 25/06/2025
Great article in today’s Stanford Report on our recent work deciphering how yew trees produce Taxol @sattelylab.bsky.social news.stanford.edu/stories/2025...
news.stanford.edu
New insights in plant gene research could boost cancer drug production
A novel approach to analyzing yew tree genes has revealed key enzymes used to make Taxol, a chemotherapy drug that’s long been difficult and costly to produce.
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SattelyLab @sattelylab.bsky.social · 11/06/2025
Fresh off the press! Check out the newest paper from the Sattely lab and @pollyfordyce.bsky.social lab! Spearheaded by @cmcclune.bsky.social #plants #plantbiology #anticancer #drug #taxol
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SattelyLab @sattelylab.bsky.social · 11/06/2025
Thanks to Jakob Franke for highlighting the Taxol/FoTO1 gene discovery and the mpXsn approach spearheaded by @cmcclune.bsky.social in @nature.com! Check it out here: www.nature.com/articles/d41... #plants #anti-cancer #singlecell #plantbiology
nature.com
Biochemical breakthrough paves way to reliable supply of anticancer drug
‘Missing’ genes needed for the biosynthesis of a natural anticancer drug have been discovered by perturbing and analysing individual cells of yew trees.
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SattelyLab @sattelylab.bsky.social · 11/06/2025
Preprint for the exciting, upcoming Nature paper! @cmcclune.bsky.social, Jack, Chloe, and Ricardo from the Sattely lab (in collaboration with @pollyfordyce.bsky.social) discovered genes for the anti-cancer drug Taxol pathway - plus a gene boosting the production of a bottleneck intermediate!
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SattelyLab @sattelylab.bsky.social · 20/05/2025
Working in science is particularly challenging these days, but hopefully, your plants offer a daily dose of joy. #plants
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SattelyLab @sattelylab.bsky.social · 28/04/2025
Congrats @caseyvchan.bsky.social to a successful Qual exam!!!😀
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SattelyLab @sattelylab.bsky.social · 17/04/2025
The 1st Annual Bay Area Plant Hub recently concluded, and it was a resounding success! We thoroughly enjoyed connecting with everyone. Hope you had a chance to stop by @caseyvchan.bsky.social 's and @taralowensohn.bsky.social 's posters. Plus listen to an intriguing discussion with Beth and others 🌱
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Department of Chemistry, Stanford University @stanfordchemistry.bsky.social · 18/03/2025
🌱 Elizabeth Sattely, Stanford Chemical Engineering professor, explores how plants turn CO2 & sunlight into molecules that boost resilience & human health. Her work aims to create crops resilient to climate change & disease, improving global food systems. #SustainableAgriculture 🌍🍃
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