Bohlen and colleagues report that the E3 ubiquitin ligase CBL is necessary for the development, tolerance and activation of B cells in humans, unlike in mice where CBL deficiency results in loss of T ...

Human inherited integrin αL (CD11a) deficiency selectively impairs skin homing of T cells and surveillance of commensal papillomaviruses.

Chilblains were reported in SARS-CoV-2–exposed individuals without PCR- or serologically defined COVID-19. Excessive TLR7 responses to SARS-CoV-2 by pDCs a

Human immunity is often insufficient against infectious agents and sometimes over-reactive to innocuous components of the environment or the human body. Ge

A new study shows that some of our cells favor genes of one parent or the other and can explain a longstanding mystery of why some people with disease-causing genes experience no symptoms.