Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Idiopathic pulmonary fibrosis is the most common and aggressive form of interstitial lung disease. Despite extensive research on the pathomechanisms of fibrogenesis, little is known about the mechanisms of fibrosis resolution. Here, lineage tracing of alveolar fibroblasts was carried out during fibrosis development and delayed resolution in aged mice. Histological analyses, single-cell transcriptomics, and ex vivo models including alveolar organoids and precision-cut lung slice cultures were employed. The data reveal that lipofibroblasts contribute to myofibroblast formation during fibrogenesis, with the reverse differentiation trajectory occurring during fibrosis resolution. Importantly, delayed resolution is associated with the persistence of ADAM metallopeptidase with thrombospondin type 1 motif 4-positive (ADAMTS4+) cells. Investigation of human lung transplant tissues, single-cell and spatial transcriptomic datasets, and functional ex vivo interventions reveal strong clinical rele

Softening of the cells on the outermost suface of the trap lets the plant move at a breakneck pace.

A new study in Nature reveals that a specific non-coding genetic sequence shapes the core social and repetitive traits of autism in males. The discovery separates these hallmark behaviors from intelle...

A new case study published in Cortex provides the first documented evidence of highly superior autobiographical memory in early adolescence. The findings reveal a 13-year-old boy who can recall his pa...

A new study of drug-related fatalities suggests that having antidepressants actively circulating in the body is associated with a lower risk of death from MDMA, raising new questions for psychiatric r...

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A participant in a landmark clinical trial has been given a cellular-reprogramming treatment that aims to rejuvenate damaged cells in the eye.

Peptide injections are the hottest trend in wellness. Researchers say enthusiasm for these unregulated drugs has got ahead of the science.

Women’s participation in science has risen sharply, but a Nature Index analysis finds that gender gaps in first and last authorship — markers of key scientific achievements — have barely shifted over the past decade.

Unprecedented results against a stubbornly hard-to-treat cancer are boosting optimism that other challenging tumors will be next

Some clinicians are pushing to broaden testosterone use, but there is debate about its benefits and risks.

An event that champions performance-boosting substances poses risks to athletes’ health — and integrity. Anti-doping science must keep up.

Challenging the classic view, two cognitive scientists argue in a new review that categorization is not a late, specialized stage of sensory processing. Instead, it is a core function operating at eve...

Categorization, the grouping of objects, living organisms, actions or events into equivalence clusters, is fundamental to adaptive behaviour. In this Perspective, Barrett and Miller discuss evidence t...

The more mice exercise, the more connections form between some neurons in their brains, study finds.

A protein reinforces the blood–brain barrier, which becomes leaky with age.

Apesar das críticas, Higuaín atingiu uma marca histórica pela Serie A e foi um dos grandes goleadores que passaram por Napoli e Juventus.

Remuneração tem descontos de Imposto de Renda e INSS; veja como calcular quanto vai receber

Festividade fará parte dos 80 anos da bomba de Hiroshima e foi anunciada por Zico em visita ao Japão; Ronaldinho Gaúcho é primeiro confirmado