iiinova — where your digital self keeps evolving

Reposted by Max

Max Perutz Labs Vienna @maxperutzlabs.ac.at · 26/06/2026

🆕 publication! How do cells build their molecular machines? Tsimafei Navalayeu (Ameres lab) in @embojournal.org maps the stepwise assembly of the RNA exosome in mammalian cells, revealing the quality control mechanisms that ensure this essential complex is built correctly ➡️ tinyurl.com/84c2298e

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Ulrich Hohmann @hohmannulrich.bsky.social · 22/06/2026

Super cool to see the result of our collaborative work with @heick.bsky.social 's lab finally out! Shaped through many discussions with @abugai.bsky.social, @lorenzoana.bsky.social & @max2max.bsky.social, @juliusbrennecke.bsky.social & Clemens, trying to decipher LENG8's secrets!

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Plaschka lab @plaschkalab.bsky.social · 18/06/2026

Now published! We investigated how polyadenylated RNAs are targeted for decay in the human nucleus. www.nature.com/articles/s41... (1/5)

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Reese Richardson @reeserichardson.bsky.social · 05/06/2026

The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)

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allepasse.bsky.social @allepasse.bsky.social · 26/01/2026

I’m happy to share the main result of my PhD, which you can find on bioRxiv www.biorxiv.org/content/10.6.... If you are interested in learning about a new way to perform DNA-PAINT multiplexing, which we call Combi-PAINT, or if you are interested in the study of mRNA conformation, keep reading! 1/10

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Filip Nemcko @nemcko.bsky.social · 29/12/2025

Do transcriptional activators work on any promoter? Our data says no. 🙅‍♂️ Despite driving ~2/3 of mammalian genes, CpG island (CGI) promoters have remained a puzzle. We identified >50 activators that are exclusively compatible with this promoter class. 🧬

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Julius Brennecke @juliusbrennecke.bsky.social · 22/12/2025

Intrigued by a long-standing conundrum in small RNA biology—how nuclear Argonaute proteins silence transposons when they *need* target transcription for their own recruitment—we studied the piRNA pathway. And found a hidden RNA-decay axis from Piwi to the RNA exosome.

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Plaschka lab @plaschkalab.bsky.social · 21/11/2025

How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)

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Plaschka lab @plaschkalab.bsky.social · 21/11/2025

Messenger RNA is made in the nucleus before it is exported to the cytoplasm for translation. But how are only correctly made mRNAs chosen and remodeled in the nucleus for export? Our new paper investigates the nuclear events leading to human mRNA export. www.nature.com/articles/s41.... (1/4)

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IMP @impvienna.bsky.social · 06/11/2025

New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at @imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys

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Ulrich Hohmann @hohmannulrich.bsky.social · 12/10/2025

Thrilled to share that I’ll be joining @imbmainz.bsky.social in February 2026 to start my own group! We will explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology. PhD positions available!

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