The human T cell repertoire is generated through recombination of a multitude of T cell receptor gene segments, yielding a complex array of T cell clones. T cell receptor beta (TRB) V gene segment def...

Combinatorial pairing of independently recombined T cell receptor (TCR) α- and β-chains is central to diversifying the TCR repertoire. Although sequence motifs in one chain correlate with epitope reco...

The efficacy of teclistamab, a bispecific antibody targeting B-cell maturation antigen and CD3, as early-line monotherapy in relapsed or refractory multiple myeloma is unclear. We randomly assigned...

Swampy mangrove forests are staging a surprise comeback - which is good news for coastal communities and the climate.

Innovative experiments are revealing how plants in the tropics can cope with heat

The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitatin...

Beneficial effects of fasting combined with endocrine therapy for oestrogen receptor-α-expressing breast cancers can be recapitulated using exogenous glucocorticoid receptor ligands instead of fasting...

Preclinical models of SARS-CoV-2 vaccination revealed a targetable CXCL10–IFN-γ axis that drives cytokine-induced cardiac injury.

Seven out of 11 patients with incurable cancer who had the treatment appear to be cancer-free.

Melvyn Bragg and guests discuss Wolfgang Pauli and the Pauli Exclusion Principle.

Nature - Multi-omics analysis of a pig-to-human decedent kidney xenotransplant

Nature - Physiology and immunology of pig-to-human decedent kidney xenotransplant

Background Donor T cell reconstitution following allogeneic hematopoietic cell transplantation (HCT) is crucial for protective immunity against infections and cancer relapse. However, its use remains ...

Antigen location orchestrates T cell–B cell collaboration in response to large pathogens.

Tissue-resident memory T cells that express TCF1 or ID3 exhibit stem-like properties and regulate memory heterogeneity and recall.

Tumor lysis syndrome has evolved and become less predictable with the introduction of new cancer therapies. This review explores risk factors and causes of the syndrome, as well as strategies for t...

Tissue-resident memory T cells that express TCF1 or ID3 exhibit stem-like properties and regulate memory heterogeneity and recall.

COVID vaccines enhance the antitumour response of immunotherapies and result in increased patient survival.

mRNA vaccines seem to boost the effectiveness of an immune therapy for skin and lung cancer ― in an unexpected way.

SARS-CoV-2 variant booster vaccination broadens human B cell responses through the germinal center reaction.

The Nobel Prize in Physics 2025 was awarded to John Clarke, Michel H. Devoret and John M. Martinis “for the discovery of macroscopic quantum mechanical tunnelling and energy quantisation in an electri...

Recent clinical successes, and profits, have prompted a rush among pharma companies to try new isotopes and targeting strategies

The cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.

Epigenetic reprogramming that promotes oxidative metabolism suppresses TH17 cell pathogenicity.

A de novo IL-21 mimic, 21h10, exhibits improved stability and potent antitumor activity in vivo compared with native IL-21.

Sepsis is treated by antibiotics but using the medication too much can lead to deadly superbugs.

mTORC1 activation by components of a cytokine cocktail enhances NK cell cytotoxicity toward cancer cells.

Tcf1 and Lef1 prime prethymic progenitors for Notch responsiveness, promoting early thymic progenitor fate and lineage stability.

Tcf1 and Lef1 prime prethymic progenitors for Notch responsiveness, promoting early thymic progenitor fate and lineage stability.

Regulatory T cells curb noxious sensory signaling to dampen cutaneous inflammation, a neuromodulatory mechanism for immunosuppression.

Glioblastoma, an aggressive brain cancer, depends on the amino acid serine as a fuel source. A serine-deficient diet has been shown to slow tumour growth in mice.

Pathogen-consuming cells found in fat tissue also play a part in lipid balance.

RNA could have helped amino acids join up without preexisting protein machinery, lab study suggests

Edits create cells that don’t trigger an immune response, allowing implant recipient to forego immune-suppressing drugs.

A rare T-cell lymphoma after chimeric antigen receptor (CAR) T-cell therapy for myeloma was linked to CCR4 overexpression and vector integration, which highlights the need for monitoring after CAR ...

Single-cell transcriptomics (scRNA-seq) has facilitated the characterization of cell state heterogeneity and recapitulation of differentiation trajectories. However, the exclusive use of mRNA measurem...

Treg cells expressing a short FOXP3 isoform exhibit a TH-like cell phenotype with reduced suppressive function and mediate antitumor immunity.

Neoadjuvant nivolumab plus chemotherapy significantly improved pathological complete response and event-free survival in patients with resectable non–small-cell lung cancer (NSCLC) in a phase 3 tri...

T cell proliferation and repertoire reconstitution is a hallmark of successful hematopoietic cell transplantation (HCT). This process may be modeled a…

History is testimony to the fallacy that the use of force can bring peace and security.

The world was explained through the laws of physics until a meteorologist saw the pattern of chaos.

Black holes are one of the mysteries of the universe where all the laws of nature as we know them stop working.

First groundbreaking images from the Biomass satellite could change our understanding of rainforests

IL-12 is dispensable for CD8 T cell responses to mRNA vaccination, but an Il12 mRNA-LNP enhances CD8 T cell memory and protection.

Temporal lobe epilepsy (TLE) is the most common type of drug-resistant epilepsy. Lowering the levels of N-methyl-d-aspartate receptor (NMDAR) ligands has been suggested as a promising therapeutic strategy for TLE. d-Serine gates synaptic NMDARs in the hippocampus but the effect of d-serine on seizure activity remains poorly understood. Here, we show that serine levels in the hippocampus were increased in persons with TLE and in a mouse model of TLE. Eliminating d-serine or blocking its binding with NMDARs suppressed seizures in mouse models. Astrocyte-derived l-serine was found to regulate interstitial d-serine levels and seizure activity through a process controlled by phosphoserine phosphatase (PSPH). We identified a potent PSPH inhibitor, Z218484536, and found that its systemic administration reduced spontaneous epileptic discharges in mouse and cynomolgus monkey models of TLE. Overall, these results indicate that PSPH is a promising therapeutic target for TLE and support further pr

Allogeneic hematopoietic cell transplantation (alloHCT) is curative for various hematologic diseases but often leads to acute graft-versus-host disease (GVHD), a potentially life-threatening complicat...