Reposted by Swiss TPH
An all-in-one pipeline for in vitro discovery and in vivo testing of Plasmodium falciparum #malaria transmission-blocking drugs
@SwissTPH.ch #DrugDiscovery #parasitology
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An all-in-one pipeline for the in vitro discovery and in vivo testing of Plasmodium falciparum malaria transmission blocking drugs - Nature Communications
Current antimalarials often fail to target mature stage V gametocytes. To aid antimalarial drug discovery, the authors present a preclinical malaria transmission-blocking drug research platform, using engineered parasites, that facilitates the screening for gametocytocidal compounds in vitro and the evaluation of transmission-blocking drug activity in vivo.
