Highlights Salk researchers investigated the impacts of entinostat, a drug that targets HDAC proteins, and found it inactivates DNA damage repair genes in pancreatic cancer cells The discovery led to ...

Highlights Researchers identify YAF9B as a protein activated by DNA damage, acting like an emergency responder to life-threatening genetic alterations in plant tissues containing stem cells Study reve...

An athlete’s mind makes countless calculations during a sporting event that the individual is never even aware of, according to research from the Salk Institute for Biological Studies.

Highlights Preclinical studies at the Salk Institute laid the foundation for a question now being tested in patients: Can a vitamin D-based therapy “reprogram” a pancreatic tumor’s protective microenv...

A small clinical trial led by Dana-Farber Cancer Institute researchers put a Salk Institute idea to the test in patients: that activating the vitamin D receptor can help reshape the protective environment surrounding pancreatic tumors in ways that could make the notoriously difficult-to-treat cancer more vulnerable to therapeutic treatments.

Highlights Salk neuroscientists found how specialized brain cells called astrocytes contribute to fragile X syndrome symptoms They discovered a protein pathway that, when suppressed, can alleviate som...

Highlights Metabolic dysfunction-associated steatotic liver disease (MASLD) is among the most common chronic liver diseases, and, when untreated, can progress to cancer, cardiovascular disease, and di...

Highlights Salk scientists find naked mole rat colonies are capable of peaceful queen succession, contrary to established understanding that succession is aggressive The study illuminates a new layer ...

Salk scientist John Reynolds, PhD, discusses the neuroscience behind hitting a fastball on FOX 5 San Diego. 

Science Can’t Wait: A Discovery Series with the Salk Institute Join the Salk Institute and the Del Mar Foundation for Science Can’t Wait, a three-part webinar series exploring breakthroughs in brain h...

Upcoming events Science Can’t Wait: A Discovery Series Webinar Series Part 1: Salk’s Year of Brain Health Date: January 28, 2026 Time: 10:00 a.m. PT/1:00 p.m. ET Where: Zoom

LA JOLLA—Young minds are easily molded. Each new experience rewires a child’s brain circuitry, adding and removing synaptic connections between neurons. These wiring patterns become more stable with a...

FOX 5 San Diego speaks with Salk scientist Terry Sejnowski, PhD about ChatGPT and the future of AI. 

The end of the shutdown did not resolve the uncertainty facing US researchers, who continue to navigate delays and budget constraints that slow scientific progress.

LA JOLLA—All the cells in an organism have the exact same genetic sequence. What differs across cell types is their epigenetics—meticulously placed chemical tags that influence which genes are express...