Highlights Salk researchers investigated the impacts of entinostat, a drug that targets HDAC proteins, and found it inactivates DNA damage repair genes in pancreatic cancer cells The discovery led to ...

Highlights Researchers identify YAF9B as a protein activated by DNA damage, acting like an emergency responder to life-threatening genetic alterations in plant tissues containing stem cells Study reve...

An athlete’s mind makes countless calculations during a sporting event that the individual is never even aware of, according to research from the Salk Institute for Biological Studies.

Highlights Preclinical studies at the Salk Institute laid the foundation for a question now being tested in patients: Can a vitamin D-based therapy “reprogram” a pancreatic tumor’s protective microenv...

A small clinical trial led by Dana-Farber Cancer Institute researchers put a Salk Institute idea to the test in patients: that activating the vitamin D receptor can help reshape the protective environment surrounding pancreatic tumors in ways that could make the notoriously difficult-to-treat cancer more vulnerable to therapeutic treatments.

Highlights Salk neuroscientists found how specialized brain cells called astrocytes contribute to fragile X syndrome symptoms They discovered a protein pathway that, when suppressed, can alleviate som...

Highlights Metabolic dysfunction-associated steatotic liver disease (MASLD) is among the most common chronic liver diseases, and, when untreated, can progress to cancer, cardiovascular disease, and di...

Highlights Salk scientists find naked mole rat colonies are capable of peaceful queen succession, contrary to established understanding that succession is aggressive The study illuminates a new layer ...

Salk scientist John Reynolds, PhD, discusses the neuroscience behind hitting a fastball on FOX 5 San Diego. 

LA JOLLA—All the cells in an organism have the exact same genetic sequence. What differs across cell types is their epigenetics—meticulously placed chemical tags that influence which genes are express...

LA JOLLA—The rate of HIV infection continues to climb globally. Around 40 million people live with HIV-1, the most common HIV strain. While symptoms can now be better managed with lifelong treatment, ...