AbstractBackground. Arterial catheter-drawn blood culture sampling may reduce patient discomfort and healthcare providers’ workload. Guidelines discourage

Clinical practice guidelines consolidate and evaluate all pertinent evidence on a specific topic available at the time of their formulation. The goal is to assist physicians in determining the most ef...

The p-value has changed from a versatile tool for scientific reasoning to a strict judge of medical information, with the usual 0.05 cutoff frequently deciding a study’s significance and subsequent cl...

Purpose To determine whether there is an interaction between baseline serum chloride concentration and pH and treatment effects in Intensive Care Unit (ICU) patients receiving intravenous fluid therap...

Intensive Care Medicine -

Ketamine, an N-methyl-D-aspartic acid receptor antagonist that was first discovered in 1962, has become established in anaesthesia providing dose-dependent anaesthetic, sedative, and analgesic effects...

Severe acute respiratory distress syndrome (ARDS) is often complicated by hemodynamic instability requiring pharmacological support. Venovenous extracorporeal membrane oxygenation (VV ECMO) is a well-...

Acute kidney injury (AKI) is a common, heterogeneous, multifactorial condition, which is part of the overarching syndrome of acute kidney diseases and disorders. This condition's incidence highest in ...

Vasoplegic shock is common, contributing up to two-thirds of cases of shock admitted to the ICU.1,2 For the two most common causes of vasoplegic shock—septic shock and vasoplegic shock after cardiopul...

Intensive Care Medicine -

Abstract. Septic shock is a significant challenge in the management of patients with burns and traumatic injuries when complicated by infection, necessitat

kidney disease (CKD) have diminished renal functional reserve, and AA may be less protective in such patients. Thus, a separate investigation of such patients is warranted. Methods: We defined CKD ...

cts. Data Sources: An updated systematic search was performed in three databases until September 4, 2024. The study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses...

Abstract. Acute kidney injury (AKI) is a common complication in critically ill and perioperative patients and is associated with mortality, morbidity, medi

Angiotensin II is an endogenous key effector of the classic renin-angiotensin system (RAS) with potent vasoconstrictor effects.1 Although exogenous angiotensin II administration has been studied since 19412 and its safety profile was confirmed in subsequent studies,3 no RAS-targeted vasopressor agent had been commercially available until recently. In 2017, a phase-3, multinational randomized controlled trial (RCT) confirmed the efficacy of a commercial preparation of angiotensin II in catecholamine-resistant vasodilatory shock,4 which led to its approval as a second-line vasopressor for this indication.

To the dismay of many statisticians, clinicians are taught to convert continuous results into a binary value to facilitate decision-making. A person with a hemoglobin A1c level of 6.5% or higher ha...

apacity for tissue homeostasis and anabolic responses. This ideally involves the accurate and timely assessment of macronutrient and micronutrient requirements, a careful evaluation of metabolic respo...

Intensive Care Medicine -

or randomized controlled trials (RCTs). Data Sources: Independent reviewers searched MEDLINE/PubMed, Scopus, and Embase databases. Study Selection: Articles were selected when they fulfilled: 1)...

Sepsis is a life-threatening, heterogeneous disorder involving a dysregulated immune response to infection. Research to identify subtypes and targeted therapies for host dysregulation is ongoing.

Background The role of intra-aortic balloon pump (IABP) combined with venoarterial extracorporeal membrane oxygenation (VA-ECMO) in patients with cardiogenic shock (CS) remains unclear. This study inv...

Background The effects of restrictive versus liberal transfusion strategies in critically ill patients with traumatic brain injury (TBI) and anemia, particularly in adult patients with moderate to sev...

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Background Treatment with short-acting betablockers in septic patients remains controversial. Two recent large multicenter trials have provided additional evidence on this therapeutic approach. We thu...