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Yiyuan (YY) Li

@yli19.bsky.social
72 followers 100 following 0 posts

Professor of Evolutionary Biology at Ningbo University. Interested in Host-symbionts Interactions, Coevolution Between Genomes, Insect Genomics, Environmental DNA yyli.weebly.com

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Reposted by Yiyuan (YY) Li
Laura Ross @laurarossevo.bsky.social · 10/09/2026
My lab @ Edinburgh university is recruiting a postdoc to work on the weird and wonderful germline-specific chromosomes of flies. elxw.fa.em3.oraclecloud.com/hcmUI/Candid... collaboration with @germline.bsky.social and yukiko yamashita funded by @novonordisk.bsky.social please repost!
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Heng Li @lh3lh3.bsky.social · 17/09/2026
Single-page, interactive overlap assembler for teaching purposes: lh3.github.io/teach-demo/o... (vibe coded)
lh3.github.io
Overlap Graph Assembly Demo
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Nancy Moran @nancy-moran.bsky.social · 24/08/2026
Insights into the role of a genotoxin in nature, through the lens of a honeybee gut. Colibactin stabilizes a symbiont community and keeps out invaders... Congratulations to Yulin Song and other authors! rdcu.be/fBIeq or (subscription) www.nature.com/articles/s41...
rdcu.be
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KamilSJaron.bsky.social @kamilsjaron.bsky.social · 23/07/2026
New preprint: 338 coleopteran genomes reveal exceptional rearrangement variation compared to other insect orders. Big congrats to @arf-mln.bsky.social, for getting this giant piece together. Big collaboration of @joanameier.bsky.social's and my groups. 🧵👇 doi.org/10.64898/202...
Phylogeny of 338 species with tips painted by the chromosomal ancestry of their contemporary genomes (well separated colours indicate only few changes, while blending indicates rearrangements). Colouring of the branches is by the number of rearrangements. The ring between paints and phylogeny indicates wether the chromosomal rearrangement was fusion dominated (brown) or fission dominated (teal) process.  
Photo credits: Udo Schmidt, Lech Borowiec, JL Tachet, David Navrátil, Fred Chevaillot, Siga, Cosmin Manci, John Hallmén, Igor Souza-Gonçalves, Alex Hyde, H. Coiffait, David Ignace, Yves Bousquet.
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Tom Mathers @tom-mathers.bsky.social · 15/06/2026
Bit late posting this... MicroFinder is now published in GigaScience: academic.oup.com/gigascience/....
academic.oup.com
MicroFinder: conserved gene-set mapping and assembly ordering for manual curation of bird dot microchromosomes
AbstractBackground. Obtaining chromosomally complete genome assemblies across the tree of life is an important goal of biodiversity genomics. However, some
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Reposted by Yiyuan (YY) Li
Jerry Maeda @jerrymaeda.bsky.social · 02/07/2026
Super grateful to have worked on this with such a talented and fun group of people! It is a really cool evolutionary story and it feels like (at least part of) a bigger mystery was solved. ✨
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Andrew Carroll @acarroll.bsky.social · 01/07/2026
How good is MiniBWA, the successor to BWA? To test it, I ran MiniBWA on sequencing from 76 different species, comparing mapping speed, rate and accuracy with BWA MEM. In short, it's really good. If you map short reads, it's well worth your time. andrewcarroll.github.io/2026/06/30/t...
andrewcarroll.github.io
The Best of Both Worlds - Assessing MiniBWA
Recently, Heng Li released MiniBWA (GitHub) alongside a paper by Heng Li and Nils Homer describing the method (paper). MiniBWA builds on the approaches in Minimap2 (also by Heng Li), but falls back on...
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Reposted by Yiyuan (YY) Li
Nancy Moran @nancy-moran.bsky.social · 02/07/2026
A step forward in discovering Buchnera's key to the aphid's heart, published today! Thanks to Jerry Maeda and other authors--a great team -- and to the helpful reviewers #SymbioSky doi: doi.org/10.1038/s415...
doi.org
A secreted endosymbiont protein essential for colonizing host cells - Nature
SyeA was present in the Buchnera ancestor, is secreted into the host cytoplasm, is homologous to secreted effectors of bacterial pathogens and is essential for Buchnera transmission.
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Reposted by Yiyuan (YY) Li
Marcella Araujo @araujosmarcella.bsky.social · 12/06/2026
Please join the Symbiosis Alumni Network during our next seminar with talks by Rowan Hart and Naama Geva-Zatorsky 🗓️ June 24th 🕥 4pm WEST 📍register on gimm.idloom.events/symbnet_semi... for link @naamagz.bsky.social @symbnet.bsky.social @moorefound.bsky.social @mblscience.bsky.social ECODIM
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Rob Waterhouse @rmwaterhouse.bsky.social · 03/02/2026
Thanks to the fantastic #biodiversity #genomics @ergabiodiv.bsky.social & @ebpgenome.bsky.social #community!
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Alejandro Manzano Marín @amanzanom.bsky.social · 30/01/2026
This is a really cool study on one of my favourite obligate symbiotic systems: Aphid + Buchnera by @jerrymaeda.bsky.social, @nancy-moran.bsky.social, & co. A secreted #endosymbiont protein (SyeA, formally Yba3) essential for colonizing host cells doi.org/10.1101/2025... #SymbioSky
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Hugo Darras @hugodarras.bsky.social · 06/01/2026
New work from @miyapan.bsky.social and our team, bringing ant, bee, and wasp labs together. @chuanxinyu.bsky.social shows that the ANTSR locus we discovered in ants has determined sex for 150+ My across bees and stinging wasps 🐜🐝, despite virtually no sequence conservation 😮 doi.org/10.1073/pnas...
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Joel Sharbrough @jsharbro.bsky.social · 03/11/2025
I am looking for a PhD student to start in my lab at UCSB in Fall 2026, studying evolutionary biology. See attached flyer for more information. Please also share with potentially interested students. Thanks!
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Texas Science @texasscience.bsky.social · 03/10/2025
The Mexican honey wasp is a bit of an oddball: it makes and eats honey like a bee, but when it’s hankering for protein, instead of pollen, it eats other insects. A new study finds its gut microbiome is more like bees than wasps. Funded by USDA and NSF. journals.asm.org/doi/10.1128/...
Two Mexican honey wasps, which are bee-like insects with black bodies, yellow stripes on the lower abdomen and honey-colored wings. Photo credit: Alex Wild.
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Nancy Moran @nancy-moran.bsky.social · 04/10/2025
Jo Holley led an undergrad team for this study, about wasps that are trying to be bees, using a new microbiome.
journals.asm.org
Honey wasps differ from other wasps in possessing large gut communities dominated by host-restricted bacteria | mBio
Honey-feeding social insects such as honey bees and bumble bees have conserved gut bacterial communities that are transmitted among nestmates. These bacteria benefit hosts by providing defense against...
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Jerry Maeda @jerrymaeda.bsky.social · 30/06/2025
Super excited to share the results of one of my favorite projects, out now in PNAS! We uncovered the mechanism of protection against fungal pathogens in the aphid-Fukatsuia symbiosis. (1/2) www.pnas.org/doi/10.1073/...
pnas.org
Heritable symbiont producing nonribosomal peptide confers extreme heat sensitivity and antifungal protection on its host | PNAS
Insects frequently form associations with maternally transmitted symbiotic bacteria. This transmission mode ensures that symbiont-conferred effects...
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Robert Kofler @rokofler.bsky.social · 11/06/2025
super-happy, three TE invasions in Dmel during the last 30 years; the crazy thing - Transib1 spread in just 2-3years in global populations academic.oup.com/mbe/advance-... great work everyone @rpianezza.bsky.social @almoroscarpa.bsky.social @signor-molevol.bsky.social Anna Haider
academic.oup.com
Spatio-temporal tracking of three novel transposable element invasions in Drosophila melanogaster over the last 30 years
Abstract. Transposable elements (TEs) are repetitive sequences capable of mobilizing within genomes, exerting a sigfinificant influence on evolution throug
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Reposted by Yiyuan (YY) Li
Kez Cleal @kezc.bsky.social · 26/06/2025
🚨 Our GW paper is out in Nature Methods!🥲 GW is a fast genomics browser (up to 100x faster!) github.com/kcleal/gw Also, just released a Python interface for GW github.com/kcleal/gwplot 📝 nature.com/articles/s4159… #Genomics #Bioinformatics
github.com
GitHub - kcleal/gw: Genome browser and variant annotation
Genome browser and variant annotation. Contribute to kcleal/gw development by creating an account on GitHub.
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Ardem Patapoutian @ardemp.bskyverified.social · 26/06/2025
“The idea that taking walks, reading things unrelated to your research, and hanging out with strangers in a campus pub should be considered part of the serious process of thinking, but might well meet with skepticism in practice.” www.pnas.org/doi/10.1073/...
pnas.org
The forgotten half of scientific thinking | PNAS
The forgotten half of scientific thinking
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Greg Hurst @greghurst.bsky.social · 12/05/2025
New preprint ex @bolinabug.bsky.social (+ @daisukekageyama.bsky.social & @scottishwormboy.bsky.social) on the pronounced secondary expansion of Spiroplasma and Rickettsia genomes in lacewings doi.org/10.1101/2025... #symbiosky 1/2
doi.org
Concerted genome expansion of heritable symbionts in an insect host
Maternally transmitted symbionts represent important components of arthropod biology, acting as both beneficial partners and as reproductive parasites. Their strict vertical transmission greatly reduc...
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Reposted by Yiyuan (YY) Li
STCmicrobeblog @stcmicrobeblog.bsky.social · 07/06/2025
#MicroSky #SymbioSky thx, seth, for pointing this out🙏
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Nancy Moran @nancy-moran.bsky.social · 02/06/2025
An update on open postdoc positions, in my group and the adjacent group of Howard Ochman, here at UT-Austin. #SymbioSky Mine: insect-bacterial symbiosis with emphasis on intracellular endosymbionts and molecular mechanisms. web.biosci.utexas.edu/moran/contac...
web.biosci.utexas.edu
Nancy Moran Contact
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Tom Mathers @tom-mathers.bsky.social · 16/05/2025
Struggling to find the tiny microchromosomes in draft bird genome assemblies? Our new #preprint introducing MicroFinder can help: www.biorxiv.org/content/10.1... 🧵 below (1/n) @sangerinstitute.bsky.social
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Laura Ross @laurarossevo.bsky.social · 01/02/2025
collaborative effort involving almost all previous postdocs in the lab and many years, but it is out and it is a great story! @kamilsjaron.bsky.social @ajmongue.bsky.social and many others
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Rob Waterhouse @rmwaterhouse.bsky.social · 21/04/2025
Wow! CONSISTENT #genome annotations for 200 insect species from different families, including 85 species previously lacking annotations www.biorxiv.org/content/10.1...
biorxiv.org
Annotation of 200 Insect Genomes with BRAKER for Consistent Comparisons across Species
The annotation of genomes lags behind their sequencing and assembly. For example, of 5,092 insect species in GenBank, as one of the most widely used databases, only 375 currently have annotated genome...
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ERGA - European Reference Genome Atlas @ergabiodiv.bsky.social · 17/04/2025
🔔 Join the ERGA Plenary this month to hear @tom-mathers.bsky.social from @sangerinstitute.bsky.social discuss his work on improving reference #genomes for challenging species. 📅 28/04 at 15:00 CEST 🔗 www.erga-biodiversity.eu/post/plenary... #biodiversity #genomics #assemblies #chromosomes #Dtol
erga-biodiversity.eu
Plenary talk - Chromosomally complete reference genomes for challenging species: overcoming sequencing dropout in bird microchromosomes
At this month's ERGA Plenary meeting, taking place on Monday, April 28 at 15:00 CEST, Dr. Thomas Mathers will present his work on a Tree of Life pilot project focused on improving reference genome ass...
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Laura Eme @lauraeme.bsky.social · 12/03/2025
🚨 New paper alert! 🚨 A robustly rooted tree of eukaryotes sheds light on their deep evolutionary ancestry—suggesting that the Last Eukaryotic Common Ancestor (LECA) may have had an excavate-like cell architecture. 🧵🔬 (1/) www.nature.com/articles/s41...
nature.com
A robustly rooted tree of eukaryotes reveals their excavate ancestry - Nature
The root of the eukaryote Tree of Life is estimated from a new, larger dataset of mitochondrial proteins including all known eukaryotic supergroups, showing it lies between two multi-supergroup assemb...
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Graham Coop @gcbias.bsky.social · 19/11/2024
Just posting this to #popgen Here's a link to my notes on population & quantitative genetics: github.com/cooplab/popg... Hoping to extend it more after the winter holidays, as I'm just finishing up teaching the undergrad version of class.
github.com
Releases · cooplab/popgen-notes
Population genetics notes. Contribute to cooplab/popgen-notes development by creating an account on GitHub.
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Reposted by Yiyuan (YY) Li
Ran Blekhman @blekhman.bsky.social · 27/01/2025
Out now, a comprehensive guide to metagenomics -- from sample collection to data analysis. This primer covers best practices, challenges, and applications in health, agriculture & environment. A roadmap for studying microbial communities 👇 www.nature.com/articles/s43...
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Rob Waterhouse @rmwaterhouse.bsky.social · 08/12/2024
76 #arthropod #genomes, five haplodiploid lineages tested have fast-evolving mitochondrial #genes & fast-evolving nuclear #genes related to mitochondrial functions --- with YY @gwct.bio fringy et al. link.springer.com/article/10.1...
link.springer.com
Rapid evolution of mitochondrion-related genes in haplodiploid arthropods - BMC Biology
Background Mitochondrial genes and nuclear genes cooperate closely to maintain the functions of mitochondria, especially in the oxidative phosphorylation (OXPHOS) pathway. However, mitochondrial genes...
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Simon Roux @simrouxvirus.bsky.social · 07/01/2025
🚨Postdoc position(s) alert🚨 If you like to develop new bioinformatic tools for *human* microbiome analysis, are interested by virus/phages, we (JGI Viral Genomics and Microbiome Data groups) may have a great position for you ! No official job posting yet, but email or DM if you are interested !
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