Kez Cleal @kezc.bsky.social · 27/03/2026Tagging for the #GeroSky community - would welcome any discussion 010
Kez Cleal @kezc.bsky.social · 26/03/2026Happy to share a new preprint exploring the idea that multicellular coordination may itself be a fundamental constraint in ageing, and asking how stochastic cellular damage is translated into tissue-level decline 🧵 www.preprints.org/manuscript/2... 120
Reposted by Kez ClealAnna Poetsch @apoetsch.bsky.social · 31/07/2025We are happy to present a new paper on gastric tumour evolution in response to peri-operative chemotherapy. www.biorxiv.org/content/10.1... 🧵 1/6biorxiv.orgTumor clone dynamics in gastro-esophageal cancer organoids reveal a non-genetic memory of neoadjuvant chemotherapy via downregulation of NFκB signalingAdenocarcinomas of the gastroesophageal junction exhibit genetic and non-genetic heterogeneity that impact clinical outcomes, though the underlying mechanisms behind drug resistance remain poorly unde... 1136
Reposted by Kez ClealDavid A Knowles @davidaknowles.bsky.social · 03/07/2025New work from the lab trying to wrap our heads around the massive complexity of the human transcriptome revealed by long-read RNA-seq! Fun collab with Gloria Sheynkman. www.biorxiv.org/content/10.1...biorxiv.orgPerplexity as a Metric for Isoform Diversity in the Human TranscriptomeLong-read sequencing (LRS) has revealed a far greater diversity of RNA isoforms than earlier technologies, increasing the critical need to determine which, and how many, isoforms per gene are biologic... 25522
Kez Cleal @kezc.bsky.social · 26/06/2025🚨 Our GW paper is out in Nature Methods!🥲 GW is a fast genomics browser (up to 100x faster!) github.com/kcleal/gw Also, just released a Python interface for GW github.com/kcleal/gwplot 📝 nature.com/articles/s4159… #Genomics #Bioinformaticsgithub.comGitHub - kcleal/gw: Genome browser and variant annotationGenome browser and variant annotation. Contribute to kcleal/gw development by creating an account on GitHub. 23717
Kez Cleal @kezc.bsky.social · 03/03/2025@adbeggs.bsky.social Hi Andrew. Fantastic talk today at the WCRC conference! It was very inspiring 👏 110
Kez Cleal @kezc.bsky.social · 26/02/2025🧬🖥️ Just released Dysgu v1.8 which now supports phasing of structural variants when using long reads. Makes SV calling much more sensitive - see PacBio benchmark 👉 github.com/kcleal/SV_Be... dysgu repo github.com/kcleal/dysgu... 084
Kez Cleal @kezc.bsky.social · 29/11/2024🧬🖥️ Sharing an update to my SV benchmark repo. More callers have been added for the CMRG/GIAB benchmarks. github.com/kcleal/SV_Be.... Also now uses #Nextflow and tests the newest #PacBio Vega data, along with #ONT kit14. Results are on the GitHub page 👉github.comGitHub - kcleal/SV_Benchmark_CMRG_GIAB: Structural variant benchmark of challenging medically relevant genesStructural variant benchmark of challenging medically relevant genes - kcleal/SV_Benchmark_CMRG_GIAB 2112
Kez Cleal @kezc.bsky.social · 18/11/2024Hi all. Just released a fast library (C++/Rust/Python) for performing interval intersections. Uses a novel superset-index that tends to be faster than current libs, and also has a SIMD accelerated counting algorithm 👇 github.com/kcleal/super...github.comGitHub - kcleal/superintervals: Fast interval intersection libraryFast interval intersection library. Contribute to kcleal/superintervals development by creating an account on GitHub. 4185
Reposted by Kez ClealRob Patro @robp.bsky.social · 12/11/2024I made a starter pack for algorithmic genomics. It's certainly incomplete, but already has a ton of awesome peeps. Let me know if you know people I should add (with a focus on algorithms and data structures in genomics) go.bsky.app/TRWCnZs 2514165
Kez Cleal @kezc.bsky.social · 11/11/2024BioNumpy looks really good, looking forward to giving this a try www.nature.com/articles/s41... 011
Reposted by Kez ClealStephen Turner @stephenturner.us · 22/10/2024I created a genomics+bioinformatics starter pack. If I left you off, *please* reply and I'll add you! go.bsky.app/B5YYBfqgo.bsky.appGenomics+Bioinformatics Starter Pack 🧬🖥️Join the conversation 99180106
