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Yan Leyfman, MD

@yleyfman.bsky.social
1.1K followers 653 following 656 posts

Physician | Executive Director & Host MedNews Week | Medical Correspondent | Conference Director | Journal Editor | Educator | Research #Oncology #COVID19 #Immunotherapy #celltherapy #tcellrx #CART #bmtsm #MedSKY #ONCSKY | About Me: nyti.ms/2VG3gUK

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Yan Leyfman, MD @yleyfman.bsky.social · 06/05/2026
Could gene therapy someday replace morphine? In the newest episode of The Translational Edge, we explore one of the boldest ideas in modern medicine with Shuf: reprogramming pain itself. This one genuinely feels like a glimpse into the future. Watch here: www.shuf.ai/episode-play...
shuf.ai
Shuf.ai
Shuf turns any medical content into a new format with AI so that you can increase your audience
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Yan Leyfman, MD @yleyfman.bsky.social · 15/04/2026
Excited to launch the 1st episode of the MedNews Week × OncoDaily partnership — built around one idea: global oncology education without borders 🌍 Tune in: lnkd.in/gUyXam9B
lnkd.in
Precision at the Core: Advancing Nasopharyngeal Carcinoma Care with Proton Beam Therapy | Episode 1
Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.
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Yan Leyfman, MD @yleyfman.bsky.social · 15/04/2026
CAR-T therapy has transformed oncology—but toxicity remains its biggest limitation. In Episode 6 of The Translational Edge, we break down one of the most important questions in the field today: Can we push efficacy further without breaking safety?
shuf.ai
Shuf.ai
Shuf turns any medical content into a new format with AI so that you can increase your audience
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Yan Leyfman, MD @yleyfman.bsky.social · 13/04/2026
Thank you to Cancer Network for the feature. Rewriting the Hemoglobin Switch: CRISPR Targeting in Sickle Cell Disease Gene editing has moved from concept to clinic. By leveraging CRISPR to reactivate fetal hemoglobin, we’re no longer just managing SCD—we’re aiming to rewrite its biology.
cancernetwork.com
Rewriting the Hemoglobin Switch: CRISPR Targeting in Sickle Cell Disease | CancerNetwork
The RUBY trial demonstrates that disrupting the BCL11A binding site in the γ-globin promoters can normalize hemoglobin in severe sickle cell disease.
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Yan Leyfman, MD @yleyfman.bsky.social · 08/04/2026
Thank you to Cancer Network for highlighting: Rethinking Dual Targeting, Durability After CAR-T in Non-Hodgkin Lymphoma CAR T works—but not for everyone.
cancernetwork.com
Rethinking Dual Targeting, Durability After CAR-T in Non-Hodgkin Lymphoma | CancerNetwork
The next frontier is not only building constructs that reduce one mechanism of relapse, but understanding why antigen-positive failures still occur.
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Reposted by Yan Leyfman, MD
OncoDaily @oncodaily.bsky.social · 08/04/2026
Episode 5 of The Translational Edge With Yan Leyfman on Exercise in Cancer Care - Jeremy Bellaiche @yleyfman.bsky.social oncodaily.com/voices/yan-l... #OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
oncodaily.com
Jeremy Bellaiche: Episode 5 of The Translational Edge With Yan Leyfman on Exercise in Cancer Care - OncoDaily
Jeremy Bellaiche: Episode 5 of The Translational Edge With Yan Leyfman on Exercise in Cancer Care / cancer, Jeremy Bellaiche, OncoDaily, Oncology, The
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Yan Leyfman, MD @yleyfman.bsky.social · 07/04/2026
Exercise isn’t just supportive care anymore—it’s becoming therapeutic. In the latest episode of The Translational Edge, we explore how exercise is quietly reshaping cancer care—impacting outcomes, biology, and survivorship in ways we’re only beginning to understand.
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Yan Leyfman, MD @yleyfman.bsky.social · 06/04/2026
Thank you to Cancer Network for highlighting: Reprogramming T Cells: The Promise of In Vivo Site-Specific CAR Engineering CAR T therapy—without the lab. A single infusion. Precise genome integration. T cells engineered in vivo. This is how we scale cellular therapy.
cancernetwork.com
Reprogramming T Cells: The Promise of In Vivo Site-Specific CAR Engineering | CancerNetwork
A landmark Nature study demonstrates targeted CRISPR-based CAR transgene integration in living patients' T cells without ex vivo manufacturing.
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Yan Leyfman, MD @yleyfman.bsky.social · 04/04/2026
Thank you to Cancer Network for highlighting my latest piece: When the World Stopped: A Lesson in Strength and Second Chances A reflection on resilience, perspective, and what oncology teaches us when time stands still. www.cancernetwork.com/view/when-th...
cancernetwork.com
When the World Stopped: A Lesson in Strength and Second Chances | CancerNetwork
Yan Leyfman, MD, reflected on resilience and hope in the face of cancer, recounting a 37-year-old diagnosed with stage IV colorectal cancer followed by HIV.
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Yan Leyfman, MD @yleyfman.bsky.social · 24/03/2026
MedNews Week is proud to announce our partnership with OncoDaily. This collaboration marks an exciting step forward as we continue to expand our platform, amplify our mission, and elevate the voices shaping the future of oncology and medicine worldwide.
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Yan Leyfman, MD @yleyfman.bsky.social · 11/03/2026
Honored to be included in this outstanding group of innovators. It is especially meaningful to be recognized alongside colleagues and mentors who have helped shape the next generation of oncology. x.com/HemOncToday/...
x.com
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Yan Leyfman, MD @yleyfman.bsky.social · 07/03/2026
Today we celebrate the extraordinary women shaping the future of medicine, science, and global education. At MedNews Week, we’ve had the privilege of learning from and collaborating with an incredible community of women leaders —
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Yan Leyfman, MD @yleyfman.bsky.social · 04/03/2026
🎙️ Big News for The Translational Edge Podcast I’m excited to share that The Translational Edge Podcast is now officially available on Spotify and Apple Podcasts, in partnership with Shuf.
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Yan Leyfman, MD @yleyfman.bsky.social · 27/02/2026
Grateful for the opportunity to present 2 oral presentations today to more than 160 attendees at the MSKCC Global Health Equity Conference. The questions were thoughtful, challenging, and exactly what moves work forward. That kind of engagement is why academic medicine matters.
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OncoDaily @oncodaily.bsky.social · 24/02/2026
Clinicians Must Shape How AI Impacts Patient Care - Yan Leyfman @yleyfman.bsky.social oncodaily.com/voices/yan-l... #OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
oncodaily.com
Yan Leyfman: Clinicians Must Shape How AI Impacts Patient Care - OncoDaily
Yan Leyfman: Clinicians Must Shape How AI Impacts Patient Care / AI, cancer, OncoDaily, Oncology, Yan Leyfman
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Yan Leyfman, MD @yleyfman.bsky.social · 17/02/2026
In this month’s ONCOLOGY, I write about presence, empathy, and the power of staying with our patients when language falls short. Because sometimes the most meaningful care is simply being there. Honored to share this reflection with CancerNetwork. www.cancernetwork.com/view/when-wo...
cancernetwork.com
When Words Fall Short: A Lesson in Silence and Compassion | CancerNetwork
This section aims to enhance provider empathy, mitigate burnout, and center the patient’s lived experience within the rigorous framework of medical science.
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OncoDaily @oncodaily.bsky.social · 16/02/2026
Seeing Trainees Move from Learners to Published Authors - Yan Leyfman(@yleyfman.bsky.social) oncodaily.com/voices/yan-l... #OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
oncodaily.com
Yan Leyfman: Seeing Trainees Move from Learners to Published Authors - OncoDaily
Yan Leyfman: Seeing Trainees Move from Learners to Published Authors / Ariana Pelosci, cancer, Chandler Park, Ishan Paduvagere, Jenna Ghazal, MedNews Week,
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OncoDaily @oncodaily.bsky.social · 15/02/2026
Why ASCT Remains Foundational Amid Modern Myeloma Advances - Yan Leyfman(@yleyfman.bsky.social) oncodaily.com/voices/yan-l... #OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
oncodaily.com
Yan Leyfman: Why ASCT Remains Foundational Amid Modern Myeloma Advances - OncoDaily
Yan Leyfman: Why ASCT Remains Foundational Amid Modern Myeloma Advances / ASCT, cancer, Chandler H Park, Ishan Paduvagere, Jenna Ghazal, multiple myeloma,
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Yan Leyfman, MD @yleyfman.bsky.social · 05/02/2026
On World Cancer Day, honored to share my story with Oncology Times. What began as childhood tragedy became a lifelong calling in oncology—rooted in empathy, service, and healing. Grateful for the platform and the chance to reflect. 🎧 Listen here: ow.ly/yj8t50Y8TE8
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Yan Leyfman, MD @yleyfman.bsky.social · 02/02/2026
Very excited to present these abstracts at the 2026 Tandem Meeting 🌍 Forever grateful to my mentors Dr. Bonilla and Dr. Park for their support and guidance 🙏, and to an incredible team of co-authors it was a pleasure to work with on these important projects 💡🤝.
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Yan Leyfman, MD @yleyfman.bsky.social · 24/01/2026
5 minutes. Anonymous. Your voice in how AI shapes medicine. 🧠🩺
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OncoDaily @oncodaily.bsky.social · 22/01/2026
Survey for Real-World Insights on AI Use in Medicine - Yan Leyfman @yleyfman.bsky.social oncodaily.com/voices/yan-l... #OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
oncodaily.com
Yan Leyfman: Survey for Real-World Insights on AI Use in Medicine - OncoDaily
Yan Leyfman: Survey for Real-World Insights on AI Use in Medicine / cancer, OncoDaily, Oncology, Yan Leyfman
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Yan Leyfman, MD @yleyfman.bsky.social · 22/01/2026
📣How are you actually using AI in practice?📣 We’re running a very short, anonymous survey (⏱️ 5 minutes) looking at real-world AI use in medicine — from documentation to clinical decision-making. #AIinMedicine #DigitalHealth #AIinHealthcare #ClinicalPractice #PhysicianVoices
docs.google.com
The Competence - Confidence Gap in AI Oncology [Long Version]
Thank you for participating in this survey on the use of artificial intelligence (AI) in oncology practice. This anonymous survey explores how oncology clinicians interact with different AI tools in ...
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Yan Leyfman, MD @yleyfman.bsky.social · 21/01/2026
🧠⚕️ Beyond board exams: evaluating AI for real-world medicine Large language models can ace medical licensing exams—but that says little about how they perform in day-to-day clinical practice. Enter MedHELM, a new framework designed to evaluate medical AI where it actually matters.
nature.com
Holistic evaluation of large language models for medical tasks with MedHELM - Nature Medicine
MedHELM, an extensible evaluation framework including a new taxonomy for classifying medical tasks and a benchmark of many datasets across these categories, enables the evaluation of large language mo...
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Yan Leyfman, MD @yleyfman.bsky.social · 17/01/2026
🧠💥 Decoding how opioids relieve pain—beyond sensation New work reveals how the anterior cingulate cortex (ACC) encodes the affective dimension of chronic pain—and how opioids selectively modulate this circuit.
nature.com
Mimicking opioid analgesia in cortical pain circuits - Nature
The anterior cingulate cortex encodes affective pain behaviours modulated by opioids; targeting opioid-sensitive neurons through a new chemogenetic gene therapy replicates the analgesic effects of mor...
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Yan Leyfman, MD @yleyfman.bsky.social · 15/01/2026
🦴🧬 Precision RNA delivery for osteoarthritis Intra-articular RNA therapeutics hold promise in OA—but efficacy hinges on getting the therapy to the right cartilage, at the right disease stage.
nature.com
Client Challenge
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Yan Leyfman, MD @yleyfman.bsky.social · 14/01/2026
🧠🔊 Mapping consciousness with precision A new review highlights transcranial focused ultrasound (tFUS) as a breakthrough, non-invasive tool for probing the neural basis of conscious perception in humans.
sciencedirect.com
Transcranial focused ultrasound for identifying the neural substrate of conscious perception
Identifying what aspects of brain activity are responsible for conscious perception remains one of the most challenging problems in science. While pro…
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Yan Leyfman, MD @yleyfman.bsky.social · 13/01/2026
CAR-T saves lives—but we’re still missing the full picture 🧩 In Episode 8 of The Translational Edge, we dive into a novel method 🔬 that could transform how we monitor CAR-T cells in patients—answering long-standing questions about persistence, trafficking, and real-time response 📊
shuf.ai
Shuf.ai
Shuf turns any medical content into a new format with AI so that you can increase your audience
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Reposted by Yan Leyfman, MD
OncoDaily @oncodaily.bsky.social · 28/12/2025
Adipose Manipulation Transplantation as a New Cancer Therapy Platform - Yan Leyfman @yleyfman.bsky.social oncodaily.com/voices/yan-l... #OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
oncodaily.com
Yan Leyfman: Adipose Manipulation Transplantation as a New Cancer Therapy Platform - OncoDaily
Yan Leyfman: Adipose Manipulation Transplantation as a New Cancer Therapy Platform / cancer, OncoDaily, Oncology, Pancreatic Cancer, Yan Leyfman
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Yan Leyfman, MD @yleyfman.bsky.social · 21/12/2025
🚀 Join the Expanding MedNews Week Team! MedNews Week is a global virtual medical education platform reaching 100+ countries and 40,000+ attendees per event.
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Reposted by Yan Leyfman, MD
OncoDaily @oncodaily.bsky.social · 22/12/2025
Uncovering Site-Specific Immune and Stromal Differences in Primary and Metastatic PDAC - Yan Leyfman @yleyfman.bsky.social oncodaily.com/voices/yan-l... #OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #PDAC
oncodaily.com
Yan Leyfman: Uncovering Site-Specific Immune and Stromal Differences in Primary and Metastatic PDAC - OncoDaily
Yan Leyfman: Uncovering Site-Specific Immune and Stromal Differences in Primary and Metastatic PDAC / Alyssa M. Krasinskas, Ayana T. Ruffin, Bassel F.
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Yan Leyfman, MD @yleyfman.bsky.social · 21/12/2025
🚀 Join the Expanding MedNews Week Team! MedNews Week is a global virtual medical education platform reaching 100+ countries and 40,000+ attendees per event.
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Reposted by Yan Leyfman, MD
OncoDaily @oncodaily.bsky.social · 29/11/2025
New Evidence Highlights the Power of the Patient Voice in Oncology - Yan Leyfman @yleyfman.bsky.social oncodaily.com/voices/yan-l... #OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
oncodaily.com
Yan Leyfman: New Evidence Highlights the Power of the Patient Voice in Oncology - OncoDaily
Yan Leyfman: New Evidence Highlights the Power of the Patient Voice in Oncology / Ali Benour, Andrea Bezjak, Andrew Mihalache, cancer, Carlton Johnny, David
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OncoDaily @oncodaily.bsky.social · 01/12/2025
MedNews Week Celebrates 4-Year Anniversary - Yan Leyfman @yleyfman.bsky.social oncodaily.com/voices/yan-l... #OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
oncodaily.com
Yan Leyfman: MedNews Week Celebrates 4-Year Anniversary - OncoDaily
Yan Leyfman: MedNews Week Celebrates 4-Year Anniversary / Alexandra Van de Kieft, Arturo Loaiza-Bonilla, cancer, Chandler H Park, Gayathri Pramil Menon, Ghena
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OncoDaily @oncodaily.bsky.social · 04/12/2025
A Global, Volunteer Model for Accurate and Inclusive Cancer Education - Yan Leyfman @yleyfman.bsky.social oncodaily.com/voices/yan-l... #OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
oncodaily.com
Yan Leyfman: A Global, Volunteer Model for Accurate and Inclusive Cancer Education - OncoDaily
Yan Leyfman: A Global, Volunteer Model for Accurate and Inclusive Cancer Education / cancer, MedNews Week, OncoDaily, Oncology, Yan Leyfman
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OncoDaily @oncodaily.bsky.social · 16/11/2025
Ultra-Processed Foods and Early-Onset Colorectal Neoplasia - Yan Leyfman @yleyfman.bsky.social oncodaily.com/voices/yan-l... #OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
oncodaily.com
Yan Leyfman: Ultra-Processed Foods and Early-Onset Colorectal Neoplasia - OncoDaily
Yan Leyfman: Ultra-Processed Foods and Early-Onset Colorectal Neoplasia / Alberto Puccini, cancer, colorectal cancer, Colorectal Neoplasia, David Foureau,
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OncoDaily @oncodaily.bsky.social · 11/11/2025
Brian Van Tine: The Truly Great Ones Leave Us Far Too Soon - Yan Leyfman @yleyfman.bsky.social oncodaily.com/voices/brian... #OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
oncodaily.com
Yan Leyfman: Brian Van Tine - The Truly Great Ones Leave Us Far Too Soon - OncoDaily
Yan Leyfman: Brian Van Tine - The Truly Great Ones Leave Us Far Too Soon / Brian Van Tine, cancer, OncoDaily, Oncology, Yan Leyfman
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Yan Leyfman, MD @yleyfman.bsky.social · 10/11/2025
In life, we meet many people—many leaders, mentors, and friends—but the truly great ones leave us far too soon. I met Dr. Brian Van Tine about four years ago at ASCO, and he immediately stood out as one of the most jovial, energetic, and compassionate individuals one could hope to meet.
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Yan Leyfman, MD @yleyfman.bsky.social · 08/11/2025
An important perspective on medical misinformation in the modern era. www.medscape.com/viewarticle/...
medscape.com
Cancer Misinformation: When Influencers Co-Opt Care
Experts explore the messy intersection between evidence-based cancer care and an enticing wellness industry dominated by social media influencers who often spread cancer misinformation.
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Yan Leyfman, MD @yleyfman.bsky.social · 30/10/2025
Thank you to OncLive for the opportunity to share my thoughts on this important update. www.cancernetwork.com/view/clinica... @onclive.bsky.social
cancernetwork.com
Clinical Implications Remain After Dasatinib CRL in CML/ALL | CancerNetwork
The FDA's CRL for the HyNap formulation of dasatinib due to manufacturing issues does not affect the efficacy or availability of standard dasatinib.
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Reposted by Yan Leyfman, MD
OncoDaily @oncodaily.bsky.social · 24/09/2025
Honored to Join the Advisory Board of CancerNetwork - Yan Leyfman @yleyfman.bsky.social oncodaily.com/career/advis... #OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #CancerNetwork
oncodaily.com
Yan Leyfman: Honored to Join the Advisory Board of CancerNetwork - OncoDaily
Yan Leyfman: Honored to Join the Advisory Board of CancerNetwork / cancer, CancerNetwork, OncoDaily, Oncology, ONCOLOGY/CancerNetwork, Yan Leyfman
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Yan Leyfman, MD @yleyfman.bsky.social · 23/09/2025
I’m deeply honored to join the Advisory Board of ONCOLOGY / CancerNetwork. 🎉 Thank you to Ariana Pelosci & the editorial team for this invitation — I’m grateful for the opportunity to work alongside such an esteemed group of clinical and scientific leaders. 🙏
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Yan Leyfman, MD @yleyfman.bsky.social · 03/09/2025
Grateful to the Humanity Rx Podcast for highlighting my story, my passion for oncology & my commitment to advancing patient care & research innovation. As one of the few remaining survivors of the after-effects of Chernobyl, my own complex medical journey as a child shaped my path toward medicine.
pod.link
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OncoDaily @oncodaily.bsky.social · 10/08/2025
Yan Leyfman: FDA Accepts Bristol Myers Squibb’s Breyanzi for Priority Review as a Potential Treatment for Relapsed MZL @yleyfman.bsky.social @bristolmyerssquibb.bsky.social oncodaily.com/voices/yan-l... #Cancer #Oncology #OncoDaily #Health #Medicine
oncodaily.com
Yan Leyfman: FDA Accepts Bristol Myers Squibb's Breyanzi for Priority Review as a Potential Treatment for Relapsed MZL - OncoDaily
Yan Leyfman: FDA Accepts Bristol Myers Squibb's Breyanzi for Priority Review as a Potential Treatment for Relapsed MZL / Bristol Myers Squibb, cancer, FDA,
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Yan Leyfman, MD @yleyfman.bsky.social · 06/08/2025
🎥 MedNews Week x OncLive x Women in Lymphoma Present: 🌟 Voices in Lymphoma: Women Shaping Care 🌟 Career Development & Mentorship in Medicine 🗓️ Tuesday, August 12 ⏰ 6:30 PM EST
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Yan Leyfman, MD @yleyfman.bsky.social · 03/08/2025
🧪 Real-world study supports talquetamab as a viable bridging strategy to BCMA CAR-T in RRMM 🔄 📌 Key Takeaways: Talquetamab bridging is feasible, safe, and effective, enabling rapid disease control with low-grade toxicities.
ashpublications.org
Sequential Targeting in Multiple Myeloma: Talquetamab, a GPRC5D bispecific antibody, as a Bridge to BCMA CAR-T cell therapy
Key Points. Talquetamab bridging is feasible, safe and effective allowing rapid disease control with minimal grade toxicity.Talquetamab enabled transition
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Yan Leyfman, MD @yleyfman.bsky.social · 27/07/2025
🧬✨ Hope Through Mitochondrial Donation A UK reproductive program offering pronuclear transfer (a form of mitochondrial donation) to women with pathogenic mtDNA variants has resulted in 8 healthy live births.
nejm.org
Mitochondrial Donation in a Reproductive Care Pathway for mtDNA Disease | NEJM
Pathogenic variants in mitochondrial DNA (mtDNA) are a common cause of severe, often fatal, inherited metabolic disease. A reproductive care pathway was implemented to provide women carrying pathog...
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Yan Leyfman, MD @yleyfman.bsky.social · 08/07/2025
🎥 MedNews Week x OncLive x Women in Lymphoma Present: 🌟 Voices in Lymphoma: Women Shaping Care 🌟 💡 Follicular Lymphoma: General Concept and First Line Strategies 🗓️ Tuesday, July 15 ⏰ 6:30 PM EST
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OncoDaily @oncodaily.bsky.social · 06/07/2025
AI’s Role in Guiding Immunotherapy Decisions in Nasopharyngeal Carcinoma - Yan Leyfman @yleyfman.bsky.social oncodaily.com/insight/yan-... #OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #AI #NPC #NasopharyngealCarcinoma
oncodaily.com
Yan Leyfman: AI's Role in Guiding Immunotherapy Decisions in Nasopharyngeal Carcinoma - OncoDaily
Yan Leyfman: AI's Role in Guiding Immunotherapy Decisions in Nasopharyngeal Carcinoma / C. Huang, C. Xie, cancer, Cancer research, F. Xie, F. Zhong, J. Chen,
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Yan Leyfman, MD @yleyfman.bsky.social · 27/06/2025
A breakthrough for blood cancer detection? In a Nature Medicine study—published just days after their labs were damaged in an Iranian missile attack—Shlush, Tanay, Furer, Milman & Rappoport reveal a potential game-changer:
nature.com
A reference model of circulating hematopoietic stem cells across the lifespan with applications to diagnostics - Nature Medicine
A large single-cell transcriptomic-based reference model for hematopoietic stem and progenitor cells from 148 age- and sex-diverse individuals identifies physiological and disease-specific changes acr...
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