iiinova — where your digital self keeps evolving

Yan Leyfman, MD @yleyfman.bsky.social · 06/05/2026

Could gene therapy someday replace morphine? In the newest episode of The Translational Edge, we explore one of the boldest ideas in modern medicine with Shuf: reprogramming pain itself. This one genuinely feels like a glimpse into the future. Watch here: www.shuf.ai/episode-play...

shuf.ai

Shuf.ai

Shuf turns any medical content into a new format with AI so that you can increase your audience

010

Yan Leyfman, MD @yleyfman.bsky.social · 15/04/2026

More than anything, conversations like this are why we built MedNews Week — to learn from those not just advancing oncology, but redefining how we think about it.

000

Yan Leyfman, MD @yleyfman.bsky.social · 15/04/2026

What stood out wasn’t just the content, but the clarity of thought. The ability to distill complex, rapidly evolving science into frameworks that actually move clinical care forward is rare — and that came through throughout.

100

Yan Leyfman, MD @yleyfman.bsky.social · 15/04/2026

Dr. Chua’s work in nasopharyngeal cancer has helped shape clinical trials and inform practice worldwide — a voice that carries well beyond any single institution.

100

Yan Leyfman, MD @yleyfman.bsky.social · 15/04/2026

Kicking things off with Dr. Melvin L.K. Chua, a globally recognized radiation oncologist and leader in precision oncology, whose perspective reflects exactly where the field is heading — data-driven care, biomarker-guided strategies, and true international collaboration.

100

Yan Leyfman, MD @yleyfman.bsky.social · 15/04/2026

From CRS to ICANS, this episode reframes how we think about risk, monitoring, and the future of cellular therapy. This isn’t just about side effects—it’s about redefining the limits of innovation. 🎧 Tune in: www.shuf.ai/episode-play...

shuf.ai

Shuf.ai

Shuf turns any medical content into a new format with AI so that you can increase your audience

010

Yan Leyfman, MD @yleyfman.bsky.social · 15/04/2026

CAR-T therapy has transformed oncology—but toxicity remains its biggest limitation. In Episode 6 of The Translational Edge, we break down one of the most important questions in the field today: Can we push efficacy further without breaking safety?

shuf.ai

Shuf.ai

Shuf turns any medical content into a new format with AI so that you can increase your audience

100

Yan Leyfman, MD @yleyfman.bsky.social · 13/04/2026

Thank you to Cancer Network for the feature. Rewriting the Hemoglobin Switch: CRISPR Targeting in Sickle Cell Disease Gene editing has moved from concept to clinic. By leveraging CRISPR to reactivate fetal hemoglobin, we’re no longer just managing SCD—we’re aiming to rewrite its biology.

cancernetwork.com

Rewriting the Hemoglobin Switch: CRISPR Targeting in Sickle Cell Disease | CancerNetwork

The RUBY trial demonstrates that disrupting the BCL11A binding site in the γ-globin promoters can normalize hemoglobin in severe sickle cell disease.

100

Yan Leyfman, MD @yleyfman.bsky.social · 08/04/2026

Relapse still defines the field. Dual targeting aims to change that. But durability isn’t just about antigen escape. Even antigen-positive disease can fail. This is the next frontier: Not just building better CARs—but understanding why remissions don’t last.

cancernetwork.com

Rethinking Dual Targeting, Durability After CAR-T in Non-Hodgkin Lymphoma | CancerNetwork

The next frontier is not only building constructs that reduce one mechanism of relapse, but understanding why antigen-positive failures still occur.

110

Yan Leyfman, MD @yleyfman.bsky.social · 07/04/2026

From muscle signaling to tumor microenvironment modulation, this is where lifestyle meets translational science. 🎧 Tune in: www.shuf.ai/episode-play... Let me know what surprised you most.

shuf.ai

Shuf.ai

Shuf turns any medical content into a new format with AI so that you can increase your audience

000

Yan Leyfman, MD @yleyfman.bsky.social · 07/04/2026

Exercise isn’t just supportive care anymore—it’s becoming therapeutic. In the latest episode of The Translational Edge, we explore how exercise is quietly reshaping cancer care—impacting outcomes, biology, and survivorship in ways we’re only beginning to understand.

110

Yan Leyfman, MD @yleyfman.bsky.social · 06/04/2026

Thank you to Cancer Network for highlighting: Reprogramming T Cells: The Promise of In Vivo Site-Specific CAR Engineering CAR T therapy—without the lab. A single infusion. Precise genome integration. T cells engineered in vivo. This is how we scale cellular therapy.

cancernetwork.com

Reprogramming T Cells: The Promise of In Vivo Site-Specific CAR Engineering | CancerNetwork

A landmark Nature study demonstrates targeted CRISPR-based CAR transgene integration in living patients' T cells without ex vivo manufacturing.

110

Yan Leyfman, MD @yleyfman.bsky.social · 04/04/2026

Thank you to Cancer Network for highlighting my latest piece: When the World Stopped: A Lesson in Strength and Second Chances A reflection on resilience, perspective, and what oncology teaches us when time stands still. www.cancernetwork.com/view/when-th...

cancernetwork.com

When the World Stopped: A Lesson in Strength and Second Chances | CancerNetwork

Yan Leyfman, MD, reflected on resilience and hope in the face of cancer, recounting a 37-year-old diagnosed with stage IV colorectal cancer followed by HIV.

000

Yan Leyfman, MD @yleyfman.bsky.social · 24/03/2026

This is only the beginning. The best is yet to come. @oncodaily.bsky.social

000

Yan Leyfman, MD @yleyfman.bsky.social · 24/03/2026

Together, we are creating a space that not only shares knowledge—but builds leaders, fosters global collaboration, and shines a light on talent across every corner of the world. Our mission remains unchanged. We are MedNews Week — connecting medicine, globally.

100

Yan Leyfman, MD @yleyfman.bsky.social · 24/03/2026

MedNews Week is proud to announce our partnership with OncoDaily. This collaboration marks an exciting step forward as we continue to expand our platform, amplify our mission, and elevate the voices shaping the future of oncology and medicine worldwide.

100

Yan Leyfman, MD @yleyfman.bsky.social · 11/03/2026

Honored to be included in this outstanding group of innovators. It is especially meaningful to be recognized alongside colleagues and mentors who have helped shape the next generation of oncology. x.com/HemOncToday/...

x.com

000

Yan Leyfman, MD @yleyfman.bsky.social · 07/03/2026

MedNews Week remains deeply committed to amplifying the voices of women leaders in medicine globally. #InternationalWomensDay #WomenInMedicine #MedNewsWeek #WomenInScience #PhysicianLeadership

000

Yan Leyfman, MD @yleyfman.bsky.social · 07/03/2026

Happy International Women’s Day to these remarkable leaders — and to women in medicine everywhere. 🌍💜 Grateful to learn from you all.

100

Yan Leyfman, MD @yleyfman.bsky.social · 07/03/2026

Your leadership advances patient care, drives discovery, and empowers others to push medicine forward. Thank you for your mentorship, your brilliance, and for continuously lifting others along the way.

110

Yan Leyfman, MD @yleyfman.bsky.social · 07/03/2026

clinicians, researchers, educators, and innovators who generously share their expertise and inspire the next generation of physicians around the world.

100

Yan Leyfman, MD @yleyfman.bsky.social · 07/03/2026

Today we celebrate the extraordinary women shaping the future of medicine, science, and global education. At MedNews Week, we’ve had the privilege of learning from and collaborating with an incredible community of women leaders —

100

Yan Leyfman, MD @yleyfman.bsky.social · 04/03/2026

🎧 Start listening here: Spotify open.spotify.com/show/2j5pUYv... Apple Podcasts creators.spotify.com/pod/profile/... Shuf www.shuf.ai/episode-play... New weekly episodes dive into the cutting edge of translational medicine — and we’re just getting started.

open.spotify.com

E15 - The first universal base edited CAR-T cells

100

Yan Leyfman, MD @yleyfman.bsky.social · 04/03/2026

If you're curious about where medicine is heading over the next decade, this podcast is for you. Through conversations at the intersection of science, innovation, and clinical care, The Translational Edge explores how discoveries move from bench → bedside → real patient impact.

open.spotify.com

E15 - The first universal base edited CAR-T cells

100

Yan Leyfman, MD @yleyfman.bsky.social · 04/03/2026

Each episode breaks down the most exciting breakthroughs in modern medicine, from: 🧬 CAR-T and next-generation cellular therapies 🧬 Gene editing and immunotherapy 🧬 Transformative clinical trials 🧬 Innovations that are redefining how we treat cancer and disease

100

Yan Leyfman, MD @yleyfman.bsky.social · 04/03/2026

This podcast was built around one idea: The future of medicine is happening now — and we need to translate it.

open.spotify.com

E15 - The first universal base edited CAR-T cells

100

Yan Leyfman, MD @yleyfman.bsky.social · 04/03/2026

🎙️ Big News for The Translational Edge Podcast I’m excited to share that The Translational Edge Podcast is now officially available on Spotify and Apple Podcasts, in partnership with Shuf.

200

Yan Leyfman, MD @yleyfman.bsky.social · 27/02/2026

Thank you again to my mentors Dr. Arturo LoAIza-Bonilla and Dr. Chandler Park, and to collaborators whose guidance and trust continue to shape this work — truly a team effort More work to do.

000

Yan Leyfman, MD @yleyfman.bsky.social · 27/02/2026

This institution played a meaningful role in shaping me early in my training, so returning to share work at this stage felt especially full circle. Thank you to everyone who engaged so deeply in the discussion.

100

Yan Leyfman, MD @yleyfman.bsky.social · 27/02/2026

Grateful for the opportunity to present 2 oral presentations today to more than 160 attendees at the MSKCC Global Health Equity Conference. The questions were thoughtful, challenging, and exactly what moves work forward. That kind of engagement is why academic medicine matters.

100

Yan Leyfman, MD @yleyfman.bsky.social · 17/02/2026

In this month’s ONCOLOGY, I write about presence, empathy, and the power of staying with our patients when language falls short. Because sometimes the most meaningful care is simply being there. Honored to share this reflection with CancerNetwork. www.cancernetwork.com/view/when-wo...

cancernetwork.com

When Words Fall Short: A Lesson in Silence and Compassion | CancerNetwork

This section aims to enhance provider empathy, mitigate burnout, and center the patient’s lived experience within the rigorous framework of medical science.

010

Yan Leyfman, MD @yleyfman.bsky.social · 05/02/2026

On World Cancer Day, honored to share my story with Oncology Times. What began as childhood tragedy became a lifelong calling in oncology—rooted in empathy, service, and healing. Grateful for the platform and the chance to reflect. 🎧 Listen here: ow.ly/yj8t50Y8TE8

000