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Pablo Lara-Gonzalez

@xtpablo.bsky.social
109 followers 174 following 13 posts

Assistant Professor at UC Irvine. Mitosis and C. elegans aficionado.

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Pablo Lara-Gonzalez @xtpablo.bsky.social · 02/10/2026
1/ 🚨 Excited to share the second preprint of the year from our lab! We uncovered how a cell cycle protein known to promote oocyte meiosis also plays a critical role in cancer cell mitosis. @ucibiosci.bsky.social @ucirvine.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
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Reposted by Pablo Lara-Gonzalez
Sachin Kotak @spindlebehavior.bsky.social · 15/09/2026
Can light build centrosome-like activity? 💡🔬 Yes! We introduce LISA (Light-Induced Spindle Assembly), now in @emboreports.org. By clustering Aurora A with optogenetics, we build centrosome-like activity that nucleates microtubules and rescues spindle defects after centrosome loss. shorturl.at/9h3VQ
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Carlos Conde @carlos-conde.bsky.social · 18/08/2026
Our latest preprint: elevated MPS1 drives CIN in colon cancer by sustaining the fibrous corona at metaphase kinetochores. This untimely persistence creates an extra microtubule-engagement domain providing a structural basis for merotely and chromosome mis-segregation. doi.org/10.64898/202...
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Florian Bernard @florianbrnrd.bsky.social · 24/07/2026
Everyone reduces dimensions. We reduced cells. Read our latest work on bioRxiv: Quantitative Description of C. elegans mRNA Landscapes From High Coverage Single-Cell Transcriptomes www.biorxiv.org/content/10.6...
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Pablo Lara-Gonzalez @xtpablo.bsky.social · 24/07/2026
🧵 I’m thrilled to share our new preprint! We uncovered a mechanism explaining how mitotic divisions are coordinated with early gene expression during embryogenesis. Here's the story: (1/7) www.biorxiv.org/content/10.6...
biorxiv.org
Cyclin B3-CDK1 couples translational de-repression to embryonic mitoses via OMA protein degradation in C. elegans.
During early embryogenesis, gene expression relies on maternally loaded mRNAs whose translation is controlled by RNA binding proteins. Here, we identify a critical role for the cyclin B3-CDK1 complex,...
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Genes & Development @genesdev.bsky.social · 10/07/2026
📽️ G&D Tapes 📽️ G&D Author, Jeongmin An, tells us about how kinase STK38L serves as a negative regulator of Hippo signaling, and its implications for development and cancer. In this issue of #genesdev: ➡️ genesdev.cshlp.org/content/40/13-14… UC Irvine #Hippo #YAP #cancer
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Genes & Development @genesdev.bsky.social · 23/06/2026
🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: STK38/L promote tissue growth and cancer by inhibiting the Hippo pathway By An et al. and Wenqi Wang ➡️ ow.ly/FweF50Zae9J UC Irvine #Hippo #YAP #Drosophila #cancer
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Senator Patty Murray @murray.senate.gov · 08/02/2025
This is what amounts to an ILLEGAL & indiscriminate funding cut for research centers everywhere. It will mean shuttering labs across the country, layoffs in red & blue states, and derailing lifesaving research on everything from cancer to opioid addiction. We all need to speak out to save lives.
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Dequina Nicholas @quinascience.bsky.social · 08/02/2025
This is a full on assault on education. The US is the world leader in innovation research, technology only because we as a society support it. Without support for world leading research, we will brain drain and the best and brightest will go where research thrives www.statnews.com/2025/02/07/n...
statnews.com
NIH plans to slash support for indirect research costs, sending shockwaves through science
The NIH said Friday night that it would slash support for indirect costs on all existing and future grants to 15%
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Katie Thompson-Peer @thompsonpeerlab.bsky.social · 07/02/2025
Inspired by this post, I'm hosting a phonebank at UC Irvine next week. Join if you're interested!
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