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Paulina Wanrooij @paulinawanrooij.bsky.social · 08/06/2025

Our newest paper on mitochondrial Topoisomerase 1 shows that Top1mt has only weak endoribonuclease activity and it therefore does not often generate deletions at incorporated ribonucleotides. This helps explain why ribonucleotides are tolerated in mtDNA. Read more: academic.oup.com/nar/article-...

academic.oup.com

The low endoribonuclease activity and lack of rNMP preference of human mitochondrial topoisomerase 1 protect against ribonucleotide-dependent deletions

Abstract. The incorporation of ribonucleotides (rNMPs) into the nuclear genome leads to severe genomic instability, including strand breaks and short 2–5 b

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Paulina Wanrooij @paulinawanrooij.bsky.social · 09/05/2025

Only just over a week left to apply for a postdoc position in our lab - if you are passionate about mtDNA maintenance and biochemistry or signaling, here is your chance!

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Paulina Wanrooij @paulinawanrooij.bsky.social · 22/04/2025

Two mtDNA papers of ours in one PNAS issue: #1 on the Y951N patient mutation of PolG, heroically spear-headed by Josefin Forslund #2 revealing surprising dNTP imbalance & subsequent mtDNA depletion in RRM2B-deficient mice, a great collaboration with the Chabes lab www.pnas.org/toc/pnas/122...

pnas.org

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

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Paulina Wanrooij @paulinawanrooij.bsky.social · 16/04/2025

Hello fellow mitochondriacs! Are you passionate about mtDNA? We now offer a 2-year postdoc opportunity for studies of mtDNA instability and its signaling. Apply by May 18th to join our international team in exotic Umeå. Please share! www.umu.se/en/work-with...

umu.se

Postdoctoral fellowship (2 years) to study mitochondrial DNA stability

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Paulina Wanrooij @paulinawanrooij.bsky.social · 09/02/2025

Our newest paper on mtDNA instability signaling by Gustavo Carvalho, Tran Nguyen and Bruno Repolês et al is out: Activating AMPK improves pathological phenotypes due to mtDNA depletion - Carvalho - The FEBS Journal - Wiley Online Library febs.onlinelibrary.wiley.com/doi/full/10....

febs.onlinelibrary.wiley.com

FEBS Press

In a cellular model of mitochondrial disease characterized by progressive mitochondrial DNA (mtDNA) depletion, we found that advancing mitochondrial dysfunction triggers the early and specific activa...

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Reposted by Paulina Wanrooij

Borja Ibarra @3mlab.bsky.social · 07/02/2025

We are hiring! We're looking for a Postdoctoral Researcher to explore the dynamics of human mitochondrial DNA replication at the single-molecule level. Review the details below👇or visit borjaibarralab.com 💻

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