Reposted by Anastasia Rumyantseva
What does the newborn heart need to complete its metabolic transition? Check out our paper on mitoSAM import in the postnatal mouse heart. Great work by @anarum.bsky.social and collaborators @rjdlab.bsky.social, @trevortippetts.bsky.social. @ki.se , @kawresearch.bsky.social
doi.org/10.1126/scia...
science.org
Loss of the mitochondrial SAM transporter reveals a lipoylation-dependent metabolic vulnerability in the postnatal heart
The neonatal heart experiences rapid metabolic growth after birth to meet increasing energetic and biosynthetic demands. How mitochondrial cofactor availability limits this transition remains unclear....