iiinova — where your digital self keeps evolving

Will Lawn @willlawn.bsky.social · 06/08/2026

I don't think it's the residents' responsibility to look after a public pavement though. We pay council tax. The council should look after them. You could ask @lewisham.gov.uk if they've considered spraying the weeds.

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Will Lawn @willlawn.bsky.social · 06/08/2026

Pls can @lewisham.gov.uk repave and then weed our Littlewood st pavement (SE13) so pedestrians, prams and wheelchairs can safely use it. I was told the weeds would be removed by 31 July - they aren't. Why is ours so much worse than others nearby? @liamshrivastava.bsky.social @janetdaby.bsky.social

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Will Lawn @willlawn.bsky.social · 20/05/2026

Want to participate in a randomised cannabinoid administration experiment at King's College London? We are studying the effects of THC and CBD on physiological stress, following poor sleep. You will be paid £92 for your time. Please complete this form qualtrics.kcl.ac.uk/jfe/form/SV_...

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Will Lawn @willlawn.bsky.social · 04/05/2026

And what about when doctors use the term relapse in conditions like MS or cancer? Does that have moral judgment implicit in the word too?

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Will Lawn @willlawn.bsky.social · 03/05/2026

Lots of words come from/are related to previous religious meanings. The interpretation of words changes over time. We didn't mean offence by using the term 'relapse'. We are referring to the return to drug use during abstinence in substance use disorder, which is its common meaning.

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Will Lawn @willlawn.bsky.social · 01/05/2026

We provide an overview of transcranial ultrasound stimulation (TUS) in the context of Substance Use Disorders here, including possible targets and mechanisms, and ongoing international research. doi.org/10.1007/s404...

doi.org

Transcranial Ultrasound Stimulation as an Emerging Treatment for Substance use Disorder: Promise and Precaution - Current Addiction Reports

Current Addiction Reports -

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Will Lawn @willlawn.bsky.social · 01/05/2026

Could the presence of CBD in cannabis actually increase the levels of circulating plasma THC and THC-metabolites after inhalation? That's what we report in Drug and Alcohol Dependence. Thanks to Dr Dan Hall for leading this. www.sciencedirect.com/science/arti...

sciencedirect.com

Plasma cannabinoid pharmacokinetics following the inhalation of vaporised cannabis with and without cannabidiol

The presence of cannabidiol (CBD) in cannabis may alter cannabinoid pharmacokinetics, however previous research has produced mixed results. Furthermor…

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Will Lawn @willlawn.bsky.social · 27/02/2026

First longitudinal MRI paper from our CannTeen study (n=96) shows that over 1-yr #cannabis use is associated with reductions in activity in the ventral striatum when anticipating money #reward. Congrats to Dr Martine Skumlien lead author and the whole CannTeam. www.nature.com/articles/s41...

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Will Lawn @willlawn.bsky.social · 17/02/2026

New paper led by Cassie Bloy - analysis of our KARE trial data. Studied acute psychoactive effects of IV ketamine in AUD over 3 infusions and if they explained clinical benefit. Strong altered states, but subjective effects did not mediate reduced drinking. onlinelibrary.wiley.com/doi/10.1111/...

onlinelibrary.wiley.com

The psychoactive effects of repeated ketamine infusions and their mechanistic role in the treatment of alcohol use disorder: Secondary analysis of a randomised controlled trial

Background and aims Ketamine assisted psychotherapy is a promising new treatment for alcohol use disorder (AUD). The psychoactive effects of repeated intravenous (IV) ketamine infusions in people wi...

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Will Lawn @willlawn.bsky.social · 05/01/2026

Please do this 5-minute survey which asks how you feel about people who use cannabis: qualtrics.kcl.ac.uk/jfe/form/SV_... One of my excellent undergraduate research project students has designed the study, and needs more participants. Thanks!! Fully anonymous. No payment.

qualtrics.kcl.ac.uk

Qualtrics Survey | Qualtrics Experience Management

The most powerful, simple and trusted way to gather experience data. Start your journey to experience management and try a free account today.

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Will Lawn @willlawn.bsky.social · 08/09/2025

Thanks Janet. I emailed a few times without a reply earlier in the year. I've since got a response saying your team will investigate it, alongside the council & highways team - thank you. I also look forward to discussing it at the constituent meeting on 26th September.

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Will Lawn @willlawn.bsky.social · 02/07/2025

We have published our new review 'Recent Innovations to Detect and Intervene to Prevent Opioid Overdose Deaths' led by Basak Tas and John Strang. kclpure.kcl.ac.uk/portal/en/pu...

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Will Lawn @willlawn.bsky.social · 01/07/2025

Quitting weed, in teenagers and young adults, is associated with dramatic drops in psychotic-like symptoms and depression. All LMM analyses adjusted for relevant. genetic and environmental factors. Publication expected later this year.

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Will Lawn @willlawn.bsky.social · 01/07/2025

Top-line findings: (1) cannabis use frequency predicts CUD, psychotic-like symptoms, and depression, (2) teenagers have persistently higher CUD severity, (3) additively, using cannabis frequently and being a teenager leads to highest psychotic-like symptom severity.

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Will Lawn @willlawn.bsky.social · 01/07/2025

See our 4-year longitudinal CannTeen findings in our pre-print here: osf.io/8hmy9/ Joint first authors: Ayse Doga Lamper and Layla Sadek.

osf.io

Four-year trajectories of mental health symptoms in adolescents and adults who do and do not use cannabis

Hosted on the Open Science Framework

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Will Lawn @willlawn.bsky.social · 30/06/2025

These ongoing collaborations with secondary schools are highly rewarding as I am able to deliver important, scientific, health-related information directly to adolescents and subsequently recruit teenage participants into research studies about substance use.

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Will Lawn @willlawn.bsky.social · 30/06/2025

The London Drugs Commission 2025 report and the WHO 2024 report both called for improved cannabis and drugs education for adolescents. Hopefully my credible, cannabis-specific assemblies can be a very small part of this. www.london.gov.uk/programmes-s... onlinelibrary.wiley.com/doi/full/10....

london.gov.uk

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Will Lawn @willlawn.bsky.social · 30/06/2025

The new RA will deliver many more assemblies across the South East and make assembly materials openly and freely available online for all other UK schools to use.

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Will Lawn @willlawn.bsky.social · 30/06/2025

Pleased to say that I've been awarded a small Impact Acceleration grant to scale up my cannabis education school assemblies and explore their acceptability and short-term impact on early-mid adolescents.

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Will Lawn @willlawn.bsky.social · 27/06/2025

We analysed data from the KARE trial (n=96) to examine ketamine’s (0.8mg/kg infusion) psychoactive effects in alcohol use disorder and whether they mediate treatment response. Drug effects were strong and mainly onsistent across 3 infusions, but did not mediate reduced drinking. osf.io/kbswd

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Will Lawn @willlawn.bsky.social · 11/06/2025

The London Drugs Commission report on cannabis makes several recommendations which I support. We must (1) deliver research-informed cannabis education to *early* adolescents, (2) offer evidence-based, specialist treatment for CUD to youth and adults. www.london.gov.uk/programmes-s...

london.gov.uk

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Will Lawn @willlawn.bsky.social · 24/04/2025

Enjoyed presenting at #SOBP2025 on a #cannabis symposium organised by @emesekroon.bsky.social & @jcousijn.bsky.social. I presented 4-year longitudinal CannTeen data: teens who quit cannabis have reduced psychotic-like symptoms, and over 4 yrs teens are > sensitive to impact of frequent C use on CUD.

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Dr Lucy Foulkes @lucyfoulkes.bsky.social · 26/02/2025

I've been asked why negative effects might happen in universal school MH interventions, so going to share thoughts here. Short answer is we don't know, but there are multiple (not mutually exclusive) possibilities: (thread)

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Will Lawn @willlawn.bsky.social · 25/02/2025

And if Sentia did produce GABA-induced anxiolytic effects, might it not be a relapse-promoting risk for those who are trying to completely abstain from alcohol?

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Will Lawn @willlawn.bsky.social · 25/02/2025

Instead, they report EEG results from a small open label study. The levels of GABA altering chemicals, first pass metabolism, bioabsorption, and ED50s for real subjective effects don't check out. It's misleading branding and poor science.

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Will Lawn @willlawn.bsky.social · 25/02/2025

Better than some articles but still too generous! Sentia is very expensive. Noone I know who has tried it thinks it has made them more relaxed (inc me). The creators of Sentia could easily do a blinded experiment on subjective effects, but don't.

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Will Lawn @willlawn.bsky.social · 25/02/2025

We need to better understand ketamine use in YP. And we need to improve prevention of and treatment for problem ketamine use. But when you read stories like this www.bbc.co.uk/news/article... you would think all YP are doing k. SDD in YP shows 0.4% 14-yos & 2.5% of 15-yos have used k in past yr.

bbc.co.uk

Generation K: The disturbing rise of ketamine abuse among young people

Increasing numbers of young people are using the drug, experts say. The health impacts can be catastrophic.

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Will Lawn @willlawn.bsky.social · 15/02/2025

Credit to Dr Basak Tas and Sir John Strang for this important and challenging work which I had the privilege of being involved with. This study demonstrates the feasibility of the lab model of OD. More work needed to really explore impact of dose on respiratory depression @kingsioppn.bsky.social

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Alex Stevens @profalexstevens.bsky.social · 13/02/2025

The long-awaited evaluation of Project ADDER is now out, and makes fascinating reading for all with a concern for illicit drug problems in England and Wales. A thread: 1/? ttps://www.gov.uk/government/publications/project-adder-impact-evaluation/project-adder-impact-evaluation#key-findings

gov.uk

Project ADDER: Impact evaluation

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Will Lawn @willlawn.bsky.social · 11/02/2025

Dr Basak Tas has published her important experimental work investigating the respiratory depressant effects of diamorphine in people with OUD. She increased dose of drug by 10 & 20% and measured respiratory function, in n=4. Honoured to be a part of this work. onlinelibrary.wiley.com/doi/10.1111/...

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Will Lawn @willlawn.bsky.social · 11/02/2025

It refers to the correlation between brain activity and strength of preference for buying the reward. A parametric neural correlate of 'I really want it and I will pay lots for it'.

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Will Lawn @willlawn.bsky.social · 11/02/2025

Really interesting work, thank you. Do you mind sharing why you think we see these negative consequences of these whole school interventions? (I'm sure you cover this well in your papers, bit I'm a bit lazy sorry!!!)

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Will Lawn @willlawn.bsky.social · 11/02/2025

Thanks to co-authors: Xuejun Hao, Paul Glimcher, Margaret Haney, Anna Konova, Ziva Cooper, Nicholas van Dam

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Will Lawn @willlawn.bsky.social · 11/02/2025

More research needed now with a control group of people who drugs infrequently and without problems, to clearly explore the relationships between problematic use and value signals of drugs and non-drug rewards.

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Will Lawn @willlawn.bsky.social · 11/02/2025

The paper also demonstrates the feasibility of neuroeconomic research with illicit drugs.

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Will Lawn @willlawn.bsky.social · 11/02/2025

These results have relevance for neurobehavioural theories of #SUD which postulate that SUDs are caused by altered valuation of drugs and non-drug rewards. I'm cautious to conclude much about non-drug reward processing here, but value signals for drugs look fairly normal.

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Will Lawn @willlawn.bsky.social · 11/02/2025

Cannabis value signals were detected in key reward and valuation brain regions. Much to our surprise, snack food value signals and the impact of powerful cues showed unexpected patterns of results.

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Will Lawn @willlawn.bsky.social · 11/02/2025

n=20 participants. Crossover design. 4 sessions per participant, 2 factors: reward (cannabis/snack) and stimuli (neutral/active cues).

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Will Lawn @willlawn.bsky.social · 11/02/2025

We used cutting-edge neuro-economic methodology to study how the brain produces value signals for cannabis and snacks.

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Will Lawn @willlawn.bsky.social · 11/02/2025

🚨New Paper- How does the brain value #cannabis vs. snacks? 🍃🍔 Using fMRI & real purchases, we found strong cannabis value signals in reward regions (vmPFC, ventral striatum, dpCC), but not for snacks. Thanks to PI & lead author @gillbedi.bsky.social 🔗 Read more: link.springer.com/article/10.1...

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Will Lawn @willlawn.bsky.social · 10/02/2025

NAC is a bit of a confusing substance, but it is supposed to be anti-oxidant, anti-inflammatory, boost glutathione, and modulate glutamate levels.

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Will Lawn @willlawn.bsky.social · 10/02/2025

The authors suggest contingency management + NAC might be key, given prior results.

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Will Lawn @willlawn.bsky.social · 10/02/2025

The overall 10-15% abstinence rates show how hard it is to boost cannabis abstinence in a group of youth, who do want to quit. In adult trials of SUD over 12 weeks, you may see much higher % abstinence rates.

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Will Lawn @willlawn.bsky.social · 10/02/2025

Gray et al. (2025) report a well-powered (n=192) clinical trial testing 12 weeks of daily n-acetylcysteine for youth CUD. Prelim research suggested NAC might help youth stay abstinent when trying to quit. No significant difference NAC vs. placebo here. www.nature.com/articles/s41...

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Prof Ellie Dommett @profelliedommett.bsky.social · 23/01/2025

I am delighted to see @kingscollegelondon.bsky.social in the top 10 in the world for psychology. So much hard work goes into our work, and whilst rankings are not the be-all and end-all, it's a nice way to start 2025. www.timeshighereducation.com/world-univer...

timeshighereducation.com

World University Rankings by Subject 2025: Psychology

Top Psychology school rankings 2025: Leading universities for Psychological Studies Discover the Psychology Rankings results with the definitive Times Higher Education Subject Rankings 2025.

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Will Lawn @willlawn.bsky.social · 06/02/2025

Thanks to Catch22 and Tracy Scares for inviting me to speak at their Substance Misuse meeting about adolescent cannabis use. I've worked with Catch22, supporting them in their development of new PSHE cannabis education resources, which has been super rewarding.

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Institute of Psychiatry, Psychology & Neuroscience @kingsioppn.bsky.social · 22/01/2025

We’re at @wellcometrust.bsky.social for the launch of the Atlas of Longitudinal Datasets - a free online platform that maps longitudinal datasets around the world🌎 @larseneault.bsky.social @mqmentalhealth.bsky.social 🔗https://atlaslongitudinaldatasets.ac.uk/ #AtlasLongitudinalDatasets

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Richard Branson @richardbranson.bsky.social · 13/01/2025

Fantastic to see the UK’s first drug consumption room finally open its doors in Glasgow. Congratulations to all those who made this happen. As the experience from more than 200 drug consumption rooms around the world shows, The Thistle will save many lives: www.theguardian.com/society/2025...

theguardian.com

‘All eyes are on Glasgow’: UK’s first legal drug consumption room ready to open

The Thistle will be available 365 days a year and provide a supervised space where drugs can be injected safely

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Will Lawn @willlawn.bsky.social · 11/01/2025

It was a privilege to exhibit TheDifference's IncludEd25 event, advertising my assemblies and workshops about cannabis to educators from mainstream and alternative provision schools. Everyone's efforts to boost inclusion are inspiring. Great to make such meaningful connections.

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