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Adam Wheatley

@wheatleyak.viralvaxlab.com
251 followers 135 following 0 posts

Scientist in the @viralvaxlab (viralvaxlab.com) at @TheDohertyInst, father of daughters, cyclist. Views are mine, accept no imitations.

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Reposted by Adam Wheatley
Jennifer Juno @jenjuno.viralvaxlab.com · 27/04/2025
Happy to report that Mitchell's paper on CD4 T cells and AIM assays is now available online at Science Advances! www.science.org/doi/10.1126/... Thanks to all our collaborators in @viralvaxlab.bsky.social and @thedohertyinst.bsky.social, including @assocprofashhaque.bsky.social lab
science.org
Deconvoluting TCR-dependent and -independent activation is vital for reliable Ag-specific CD4+ T cell characterization by AIM assay
CXCR4 down-regulation deconvolutes TCR-independent activation in the AIM assay.
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Reposted by Adam Wheatley
Davide Angeletti @angelettilab.bsky.social · 25/03/2025
Our latest study by PhD student #RomainGailleton shows that upon #influenza infection, #Bcell can respond rapidly by forming ectopic #GerminalCenter within the nasal tissue. The work has just been published in @pnas.org (1/N) www.pnas.org/doi/10.1073/...
pnas.org
Ectopic germinal centers in the nasal turbinates contribute to B cell immunity to intranasal viral infection and vaccination | PNAS
The nasal mucosa is the first immunologically active site that respiratory viruses encounter and establishing immunity at the initial point of path...
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Reposted by Adam Wheatley
ViralVax Lab @viralvaxlab.bsky.social · 11/03/2025
1/ Hot off the press in @jimmunol.bsky.social. We investigated how same side (ipsilateral) vs alternate side (contralateral) prime-boost vaccination impacts germinal center (GC) dynamics & antibody responses against SARS-CoV-2 spike in mice.💉🦠#immunology #vaccines @thedohertyinst.bsky.social
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Reposted by Adam Wheatley
The Journal of Immunology @jimmunol.bsky.social · 10/03/2025
New research from @thedohertyinst.bsky.social suggests that receiving multiple doses of a vaccine in the same limb leads to faster antibody development, an important strategy for providing #immunity quickly during a pandemic or disease #outbreak. #ReadTheJI #immunology ow.ly/c28N50VeRGR
ow.ly
Modulation of germinal center and antibody dynamics via ipsilateral versus contralateral immunization against SARS-CoV-2
Abstract. Human clinical trials have reported immunological outcomes can differ between ipsilateral (same side) and contralateral (alternate sides) prime-b
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