Here, the authors establish and validate two black yeasts as heterologous hosts for fungal polyketide discovery and production, combining the metabolic robustness of filamentous Aspergillus species wi...

Here, the authors establish and validate two black yeasts as heterologous hosts for fungal polyketide discovery and production, combining the metabolic robustness of filamentous Aspergillus species wi...

Fungal polyketides represent a treasure trove of industrially relevant compounds, yet sustainable high-level production can be challenging. Black yeasts have emerged as promising heterologous hosts fo...

Here, the authors establish and validate two black yeasts as heterologous hosts for fungal polyketide discovery and production, combining the metabolic robustness of filamentous Aspergillus species wi...

To be practically useful, sustainable aviation fuels need a suitable energy density and freezing point. Here the authors explore an iterative polyketide synthase family, leading to engineered biosynth...

Pesky pests can wreak havoc on plants by chewing leaves, boring into stems, and sucking sap from trees. Beyond the direct damage, they also spread harmful bacteria, viruses, and fungi that can infect and ultimately kill the crops.

Hypocrealean fungi are the most important source of fungal and insect pest biocontrol agents. By integrating phylogenomics, metabolomics and synthetic biology, we surveyed the biosynthetic capabilitie...

Crop losses from pests threaten global food security. Here, the authors survey the biosynthetic repertoire of hypocrealean fungi, identifying over 5,200 biosynthetic gene clusters, most encoding unkno...

Crop losses from pests threaten global food security. Here, the authors survey the biosynthetic repertoire of hypocrealean fungi, identifying over 5,200 biosynthetic gene clusters, most encoding unkno...

Covering: up to 2025Polyketide synthases (PKSs) are essential enzymatic systems that produce a wide range of natural products. Their biosynthetic features offer significant opportunities to create a…

A comprehensive assessment of biotic and abiotic features of cacao fermentation led to the design of a defined microbial consortium that could reproduce the fine flavour profile of chocolate under con...

Fungal natural products, including polyketides, are a rich source of bioactive molecules. Their biosynthetic enzymes are encoded within biosynthetic gene clusters, which are often activated by specifi...

Background The increasing amount of genomic data calls for tools that can create genome-scale phylogenies quickly and efficiently. Existing tools rely on large reference databases or require lengthy d...

Background Streptomyces is a highly diverse genus known for the production of secondary or specialized metabolites with a wide range of applications in the medical and agricultural industries. Several...

At a Technical University of Denmark lab, researchers are exploring the potential for fungi to be used as meat and seafood replacements.

Streptomycetes hold immense potential for discovering novel bioactive molecules for applications in medicine or sustainable agriculture. However, high-throughput exploration is hampered by the current...

Diplodia sapinea (Fr.) Fuckel is a widespread fungal pathogen affecting conifers worldwide. Infections can lead to severe symptoms, such as shoot blight, canker, tree death, or blue stain in harvested...

The genus Streptomyces are valuable producers of antibiotics and other pharmaceutically important bioactive compounds. Advances in molecular engineering tools, such as CRISPR, has provided some access...

Animals selectively acquire specific symbiotic gut bacteria from their environments that aid host fitness. To colonize, a symbiont must locate its niche and sustain growth within the gut. Adhesins are...