Vojtech Dvorak @vojtechdvorak.bsky.social · 26/11/2025www.science.org/content/blog...science.orgReverse Proteolysis, Will You Look At That 010
Reposted by Vojtech DvorakOpen Box Science @openboxscience.bsky.social · 02/06/2025OBS SPEAKER HIGHLIGHT👩🔬 How Skin Injury Primes Distant Immunity 🗣️ @mariemradhouani.bsky.social @starkllab.bsky.social lab.bsky.social @cemm-vienna.bsky.social @meduniwien.ac.at 📆 Thu, June 5, 11 pm ET 👉 Registration: us02web.zoom.us/meeting/regi... 062
Vojtech Dvorak @vojtechdvorak.bsky.social · 25/05/2025Even though this essay is supposedly a classic, I only discovered it a few days ago. It’s a great (short) read, indeed! www.cell.com/cancer-cell/...cell.comCan a biologist fix a radio?—Or, what I learned while studying apoptosisAs a freshly minted Assistant Professor, I feared that everything in my field would be discovered before I even had a chance to set up my laboratory. Indeed, the field of apoptosis, which I had recent... 010
Reposted by Vojtech Dvorakgiuliosupertifurga.bsky.social @giuliosupertifurga.bsky.social · 19/05/2025Paper(s) alert from our RESOLUTE project – In a compilation of four papers in @molsystbiol.org we show how we were deciphering cellular logistics and present a comprehensive systematic blueprint of chemical transport pathways with #SoluteCarrier transporters 11510
Reposted by Vojtech DvorakSavitski Lab @savitski-lab.bsky.social · 29/04/2025Want to know how the ligands interact with proteins beyond model cell lines, e.g., in tissues or bacteria? Interested in membrane targets? Check out our High-Throughput PELSA method which allows you do all these cool screenings for dozens of ligands within two hours! www.biorxiv.org/content/10.1...biorxiv.orgHigh-throughput peptide-centric local stability assay extends protein-ligand identification to membrane proteins, tissues, and bacteriaSystematic mapping of protein-ligand interactions is essential for understanding biological processes and drug mechanisms. Peptide-centric local stability assay (PELSA) is a powerful tool for detectin... 13216
Reposted by Vojtech DvorakMariem Radhouani @mariemradhouani.bsky.social · 04/04/2025I'm excited to share my first-author PhD paper, now out in Science Immunology! @science.org We show that S.aureus skin infection leaves a lasting imprint on bone marrow eosinophils, fueling allergic responses in the lungs. 📄 Read the full study: www.science.org/doi/10.1126/... Let’s dive in 🧵 1/9science.orgEosinophil innate immune memory after bacterial skin infection promotes allergic lung inflammationStaphylococcus aureus skin infection induces eosinophil innate immune memory to exacerbate allergen-induced airway inflammation. 58221
Reposted by Vojtech DvorakChristian Frezza @frezzalab.bsky.social · 01/02/2025Lactate homeostasis is maintained through regulation of glycolysis and lipolysis: Cell Metabolism www.cell.com/cell-metabol...cell.comLactate homeostasis is maintained through regulation of glycolysis and lipolysisLactate elevations are a hallmark of human disease, but the mechanisms regulating lactate levels remain poorly understood. Here, Lee et al. elucidate the mechanisms of lactate homeostasis. These invol... 13112
Reposted by Vojtech DvorakChemical Probes Portal @chemicalprobes.org · 28/01/2025🔬 Calling all PhD students & postdocs in chemistry/biology! Join us at the Chemical Probes Hackathon 🧪: 🗓️ Feb 20, 2025 | 10:00–14:30 📍 Vienna, Austria 💡 Evaluate chemical probes w/ experts & improve global science 🌍. 🎓 Earn a Certificate of Attendance! Learn more & register 👇 123
Reposted by Vojtech DvorakSuperti-Furga Lab @supertifurgalab.bsky.social · 07/01/2025Kicking off the new year: A collaboration between @giuliosupertifurga.bsky.social and @alessiociulli.bsky.social using a transporter-focused genetic screens revealed that the efflux pump ABCC1/MRP1 restricts PROTAC sensitivity in cancer cells. Out now in @CellChemBiol www.cell.com/cell-chemica... 0174