Quenching mitochondrial reactive oxygen species in monocyte-derived macrophages, but not in microglia, ameliorates neuroinflammation.

The central nervous system (CNS) has a unique set of macrophages that seed the tissue early during embryonic development. Microglia reside in the parenchyma, and border-associated macrophages are pres...

A preprint by Villar-Vesga et al. shows that monocyte-derived cells in the central nervous system produce mitochondrial reactive oxygen species to promote neuroinflammation.