Expanded CAG/CTG repeats cause over 15 different diseases that all remain without a disease-modifying treatment. Because repeat length accounts for most of the variation in disease severity, contracti...

Interruptions within expanded tandem repeats reduce somatic expansion and alter the severity of the resulting diseases. Consequently, much has been do…

We are pleased to announce the eight awardees in the fifth round of the UK DRI Translation Award programme – designed to unlock impact and drive translation within the Institute, kick starting the ear...

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

The UK Dementia Research Institute (UK DRI), principally funded by the Medical Research Council (MRC), and Cardiff University are seeking to appoint an outstanding established academic to a new Chair ...

In Two Minds · Episode

The UK Dementia Research Institute (UK DRI), principally funded by the Medical Research Council (MRC), and Cardiff University are seeking to appoint an outstanding established academic to a new Chair ...

The UK Dementia Research Institute (UK DRI), principally funded by the Medical Research Council (MRC), and Cardiff University are seeking to appoint an outstanding established academic to a new Chair ...

Job Details: Centre Director, MRC UK Dementia Research Institute at CardiffChair in Neuroscience, Clinical or Non-ClinicalS

Dr Gabriel Balmus at the UK Dementia Research Institute, University of Cambridge is seekign a Research Assistant to work on DNA Damage and Huntington's Disease

Expansions and contractions of tandem DNA repeats are a source of genetic variation in human populations and in human tissues: some expanded repeats cause inherited disorders, and some are also somati...

DNA repeats can lengthen or shorten during their replication, which may lead to a human disease. Here, the authors discovered that an essential replication protein, Mcm10, counteracts instability of G...

Nature Communications - DNA repeats can lengthen or shorten during their replication, which may lead to a human disease. Here, the authors discovered that an essential replication protein, Mcm10,...

Imperial researchers uncover a ‘chemical metronome’ in the brain, which helps to synchronise the master clock telling us when it’s time to sleep.

Over 50 hereditary degenerative disorders are caused by expansions of short tandem DNA repeats (STRs). (GAA)n repeat expansions are responsible for...

Huntington's disease (HD) arises from a CAG expansion in the <i>huntingtin</i> ( <i>HTT</i> ) gene beyond a critical threshold. A major thrust of current HD therapeutic development is lowering levels ...

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