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Kellie Machlus

@kmachlus.bsky.social
884 followers 559 following 94 posts

I research hematopoiesis and how megakaryocytes make platelets 🩸🔬 Associate Professor at Harvard Medical School and Boston Children’s Hospital 🏳️‍🌈 she/her #medsky #scisky #hematology

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Kellie Machlus @kmachlus.bsky.social · 30/03/2026
So fun to be a part of this groundbreaking work led by @bloodgenes.bsky.social
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Jeremy Berg @jeremymberg.bsky.social · 10/01/2026
Powerful piece in STAT this morning from some NIH staff members who have resigned www.statnews.com/2026/01/10/n... 1/3
statnews.com
The NIH has lost its scientific integrity. So we left
“We can no longer lend our credibility to an organization that has lost its integrity,” write four scientists and administrators who recently resigned from the NIH.
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Kellie Machlus @kmachlus.bsky.social · 25/11/2025
👀
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Joe Italiano @megaman55.bsky.social · 20/11/2025
Join us to pursue cutting-edge research at the interface of megakaryocyte biology and translational medicine. We have NIH-funded postdoc positions available to investigate platelet production and the broader functions of megakaryocytes. I’ll be attending ASH and would be happy to connect.
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Kellie Machlus @kmachlus.bsky.social · 07/11/2025
Excited for this session! If you’re at #AHA25 today, please join us!
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Megan Ranney MD MPH @meganranney.bsky.social · 29/07/2025
A little known - but hugely consequential - part of the government’s changes to science funding: open.substack.com/pub/sciencea...
open.substack.com
A Quiet Policy Shift That Could Devastate American Science
Why NIH’s sudden move to multi-year grant funding should alarm every principal investigator and university
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Kellie Machlus @kmachlus.bsky.social · 13/07/2025
So well put. Something I am thinking about every day with research as well.
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Kellie Machlus @kmachlus.bsky.social · 05/06/2025
This please 👇🏼
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Kellie Machlus @kmachlus.bsky.social · 15/05/2025
Now is a the time to get involved in your scientific societies. #Hematology #HemeSky @ash.hematology.org is stepping up for Hematology - HOW CAN YOU HELP? If you want to be on a committee nominate yourself or someone else below. I am also happy to nominate you, so just reach out. Deadline May 31!
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Kellie Machlus @kmachlus.bsky.social · 18/04/2025
Oh.
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Kellie Machlus @kmachlus.bsky.social · 26/03/2025
This is where we are living. www.cnn.com/2025/03/25/b...
cnn.com
Florida debates lifting some child labor laws to fill jobs vacated by undocumented immigrants | CNN Business
Florida has been working for years to crack down on employers that hire undocumented immigrants. But that presented a problem for businesses in the state that are desperate for workers to fill low-wag...
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Jeremy Berg @jeremymberg.bsky.social · 25/03/2025
The information I am receiving is consistent with the STAT story. The boards are being purged of women and minoritized scientists with no other obvious pattern. And for the cases where I have some information, the effects are not subtle...Boards going from 35% women to 10% women. 3/n
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Stand Up for Science! @standupforscience.net · 27/02/2025
The FDA just cancelled a meeting to select flu strains for next season's flu shots. "It's unclear what the canceled meeting will mean for Americans who want to get a flu vaccine next season." www.nbcnews.com/health/healt...
nbcnews.com
FDA cancels meeting to select flu strains for next season's shots
The canceled meeting comes just days after a CDC vaccine advisory committee meeting was abruptly postponed.
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Office of Mayor Michelle Wu 吳弭 @mayorwu.boston.gov · 20/02/2025
The City of Boston is leading 40+ mayors, cities, and counties in an amicus brief against the Trump Administration's drastic and illegal cuts to federal research funding—cuts that will lead to immediate job losses nationwide.
COALITION OF MAYORS ACROSS U.S. FILE AMICUS BRIEF IN OPPOSITION TO TRUMP ADMINISTRATION’S DRASTIC CUTS TO FEDERAL RESEARCH FUNDING
Led by the City of Boston, MA, City of Cleveland, OH, the Metropolitan Government of Nashville and Davidson County, TN, the Mayor of Gainesville, FL, and the Mayor of Salt Lake City, UT, over 40 mayors, cities, and counties argue that NIH cuts will cause job losses, economic disruption, and undermine U.S. competitiveness

BOSTON - Thursday, February 20, 2025 - Late yesterday, Mayor Michelle Wu co-led a coalition of Mayors from across the United States in writing and filing an amicus brief in federal district court in Boston to stop the Trump Administration's drastic and illegal cuts to federal research funding and immediate job losses in cities nationwide. Over 40 mayors, cities, and counties from across the country joined the brief. These cities are home to universities and hospitals that employ hundreds of thousands of Americans in cutting edge medical and scientific research, and the federally-funded research in these communities has made the United States the global leader in scientific discovery. The brief seeks a temporary restraining order against the Trump Administration, alongside the research universities, medical schools, hospitals, and 22 states that are plaintiffs in the three cases filed last week in federal district court.

“For decades, Congress has made a clear choice to use federally-funded research to invest in cities, build a broadly-distributed infrastructure for scientific discovery, create jobs, and drive economic growth in communities across the United States,” said Mayor Michelle Wu. “We join with cities across the country – in red states, purple states, and blue states – to stop this illegal action that will cause layoffs, lab closures, and undermine scientific progress in American cities. I thank Massachusetts Attorney General Andrea Campbell for her leadership on behalf of the research institutions of Boston.”This amicus brief is in response to the abrupt February 7, 2025 announcement by the National Institutes of Health (NIH) of an immediate reduction in funding for scientific and medical research institutions across the country. Under the NIH’s new policy, which temporarily went into effect on Monday, February 10, payments for indirect costs reimbursed to research universities would be capped at 15%, down from 30-70%. The brief makes clear that NIH funding cuts would devastate research institutions in cities across the county, cause job losses, create severe economic disruption, and undermine a critical pillar of strength and civic pride in cities across the United States. The cuts would also undermine critical medical and scientific research that residents are counting on, including cancer, diabetes, and heart disease, and jeopardize the cities’ and country’s position of global leadership on scientific advancement.
“The Gainesville community depends on this highly efficient, dependable investment of our tax dollars back into our city’s innovation economy,” said Harvey L. Ward, Mayor, City of Gainesville, Florida. “I’m glad to join other mayors in highlighting the vital role NIH funding plays in the lives of everyday hardworking American families.” 
“The breadth and diversity of this coalition highlights the devastating and widespread impact of these NIH funding changes, from Alzheimer’s research to cancer clinical trials,” said Jill Habig, Founder and CEO of Public Rights Project. “We’re proud to partner with mayors, cities, and counties in opposing this threat to critical federal funding and the health and vitality of our communities.”
On Monday, February 10th, twenty two states and associations of medical schools, hospitals, and universities, filed three related cases, and secured a temporary restraining order preventing the Trump Administration from slashing the reimbursement rates. That initial order will be revisited this week in a hearing scheduled for Feb. 21.The Public Rights Project served as amici counsel. The full list of mayors, cities and counties who joined the brief is below. 



Local Governments and Mayors



City of Boston, Massachusetts
City of Cleveland, Ohio
Harvey L. Ward, Mayor, City of Gainesville, Florida
Metropolitan Government of Nashville and Davidson County, Tennessee
Erin Mendenhall, Mayor, City of Salt Lake City, Utah
City of Alameda, California
City of Albuquerque, New Mexico 
Allegheny County, Pennsylvania
City of Baltimore, Maryland 
Emma Mulvaney-Stanak, Mayor, City of Burlington, Vermont
Township of Canton, Michigan
Town of Chapel Hill, North Carolina
City of Chicago, Illinois 
Sandra Welch, Mayor, City of Coconut Creek, Florida
City of Columbus, Ohio
City of Easthampton, Massachusetts
Daniel Biss, Mayor, City of Evanston, Illinois
City of Fairfax, Virginia
Harris County, Texas
Ravinder S. Bhalla, Mayor, City of Hoboken, New Jersey
Quinton Lucas, Mayor, Kansas City, Missouri
Indya Kincannon, Mayor, City of Knoxville, Tennessee
City of Madison, Wisconsin
Jeff Silvestrini, Mayor, City of Millcreek, Utah
Anissa Welch, Mayor, City of Milton, Wisconsin
Montgomery County, Maryland
City of New Haven, Connecticut
Dontae Payne, Mayor, City of Olympia, Washington 
Adrian O. Mapp, Mayor, City of Plainfield, New Jersey
Sue Noack, Mayor, City of Pleasant Hill, California
City of Pittsburgh and Ed Gainey, Mayor, City of Pittsburgh, Pennsylvania
City of Providence, Rhode Island 
John Clark, Mayor, Town of Ridgway, Colorado
City of Rochester, New York
City of Sacramento, California 
City and County of San Francisco, California
City of Santa Monica, California
Constantine H. Kutteh, Mayor, City of Statesville, North Carolina
Lisa Brown, Mayor, City of Spokane, Washington
Tishaura O. Jones, Mayor, City of St. Louis, Missouri 
City of St. Paul, Minnesota
Dennis R. McBride, Mayor, City of Wauwatosa, Wisconsin
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The New York Times @nytimes.com · 22/02/2025
The Trump administration blocked key parts of the federal government’s apparatus for funding biomedical research, effectively halting progress on much of the country’s future work on illnesses like cancer and addiction despite a federal judge’s order to release grant money.
nytimes.com
Trump Administration Stalls Scientific Research Despite Court Ruling
Using an arcane law, officials have effectively delayed funding from the National Institutes of Health, leaving medical studies in jeopardy.
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 21/02/2025
Ok scientists & those who love science 🧪: here is another exhortation. Call Congress TODAY about the freeze on NIH Council Meetings and Study Sections. Emphasize that this means NO new grants are being funded & labs will soon start to shut down and fire employees. Phone numbers are at: 5calls.org
5calls.org
5 Calls
Spend 5 minutes. Make 5 calls. Make your voice heard.
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Nature @nature.com · 20/02/2025
Almost all grant-review meetings under Trump 2.0 remain suspended at the US National Institutes of Health (NIH), preventing the world’s largest public funder of biomedical research from spending much of its US$47 billion annual budget. go.nature.com/4gM6oW4
go.nature.com
Revealed: NIH research grants still frozen despite lawsuits challenging Trump order
The Trump administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo.
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Gregg Gonsalves @gregggonsalves.bsky.social · 20/02/2025
This is a red alert for US science, for new cures & treatments for diseases that afflict everyone in this country. This isn't "oh, it will blow over." Soon we will have reached the point of no return destroying what it has taken decades to build. WE NEED TO BE BANGING DOWN THE DOORS IN CONGRESS.
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Kellie Machlus @kmachlus.bsky.social · 19/02/2025
Study section freeze hits NIH
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The Transmitter @thetransmitter.bsky.social · 18/02/2025
A large portion of grants awarded by the U.S. National Institutes of Health cannot be funded for the foreseeable future because of an indefinite hold on submissions to the Federal Register, according to an email reviewed by The Transmitter. By @avaskham.bsky.social bit.ly/3X8ngz8
thetransmitter.org
Federal Register hold makes ‘end run’ around court pause on NIH funding freeze
NIH-related updates to the Federal Register, which are required for the scheduling of study sections and advisory councils, are on hold indefinitely, according to an email reviewed by <i>The Transmitt...
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Kellie Machlus @kmachlus.bsky.social · 16/02/2025
Current inspiration as I continue doing my science as a form of protest and resistance. 🧪🩸💪
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Mark Cuban @mcuban.bsky.social · 09/02/2025
This is the most relevant article to NIH and research cuts I’ve seen. Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !” globalnews.ca/news/9793403...
globalnews.ca
How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca
In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.
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Jeremy Berg @jeremymberg.bsky.social · 10/02/2025
A useful tool and a great thing to do... 5calls.org/issue/nih-ns...
5calls.org
Save NIH and NSF Research Funding ⭑ 5 Calls
On February 7, the Trump administration moved to cut billions of dollars in funding from the National Institutes of Health (NIH) and National Science …
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Laura White @laurakwhite.bsky.social · 09/02/2025
There’s no argument that should reassure anyone enough to go back to business as usual, because none of these actions are happening in isolation. The war on US science won’t end with a court order on indirects.
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Carl T. Bergstrom @carlbergstrom.com · 08/02/2025
Thinking back on all this I better understand the pain I feel to see science under devastating attack here. It’s not just about my livelihood or my university. It’s about my identity. And it’s about a pursuit that I see as standing along with art, literature, and music as among our highest callings.
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Kellie Machlus @kmachlus.bsky.social · 05/02/2025
Do it. I mean, it worked out pretty well for me ... 🙃🩸🫶
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Kellie Machlus @kmachlus.bsky.social · 04/02/2025
This was so much fun to do with @aswolberg.bsky.social and @gbarnesmd.bsky.social - a chat with two great friends 🥰 Isn't that why we love this community? Great science and great people.
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Kellie Machlus @kmachlus.bsky.social · 23/01/2025
Hi friends. This is hard. Remember, you’re not alone- there are so many of us here that care a lot and aren’t giving up. Don’t stop talking and don’t let them make you hard. Reach out to someone that needs some encouragement. We are here ❤️ #sciencesky
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Yoona Kang @ykanglab.bsky.social · 12/01/2025
We are hiring 😀 Postdoctoral position – Stem cells, Cancer, and Aging We study cell fate decision and lineage specification in hematopoietic stem and multipotent progenitor populations to modulate lineage output for therapeutic purpose in diseases and aging contexts.
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Travis Fleming @tjflemin.bsky.social · 02/01/2025
Stem cell-like states confer poor outcomes in blood cancer—but what mechanisms drive this and how can they be therapeutically targeted? In our new preprint, we show how a single TF represses one enhancer to maintain a subset of high-risk leukemias: 🧵👇 www.biorxiv.org/content/10.1...
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Kellie Machlus @kmachlus.bsky.social · 23/12/2024
Machlus lab members Maria and Ginny are helping raise money for @danafarber.bsky.social this year at the #PMCWinterCycle !! 🚴 #PMC2025 #CloserByTheMile Join me in donating to the team with the most amazing name: Plaquetas Bravas 🩸🫶 profile.wintercycle.org/T00462
donate.wintercycle.org
PMC Winter Cycle - Donation
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Kellie Machlus @kmachlus.bsky.social · 10/12/2024
Made it back to Boston after an amazing #ASH24 and I need a week on an island to recover.🏝️ Anyone else?
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Kellie Machlus @kmachlus.bsky.social · 08/12/2024
Happy Sunday #ASH24 ☀️🩸! Time to get breakfast and head over to Room 28 at 9:30 to hear Ginny talk about the role of MKs and platelets in Tet2 CH
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Kellie Machlus @kmachlus.bsky.social · 06/12/2024
Amazing talk by @beaudinlab.bsky.social at the Myeloid Workshop on cochlear macrophages in hearing loss in CMV infection 🤯 #ASH24
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Kellie Machlus @kmachlus.bsky.social · 05/12/2024
Everyone headed to #ASH24 - if you’re looking for your favorite scientists in hematopoiesis to follow on here, we have you covered 👇🏼
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Kellie Machlus @kmachlus.bsky.social · 03/12/2024
The ladies of the Machlus lab are getting ready for #ASH24 🩸🧪🎉 If you see us, say HI! We will all be presenting (details below). Also, we have a Postdoc Position 👀 if you are kind of scrappy and love science…
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Kellie Machlus @kmachlus.bsky.social · 22/11/2024
A day I always look forward to - our division retreat!! Today is the 42nd (!!) Annual Vascular Biology Program Retreat The MK to Platelet Research Group is here and ready to talk science 🧪 🩸
Members of the Machlus and Italiano labs pose in front of a wall. All are excited to talk science!
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Kellie Machlus @kmachlus.bsky.social · 19/11/2024
Post a perfect album from the 90s that isn’t Nirvana, Pearl Jam, Soundgarden, or Alice in Chains.
Radiohead - OK Computer
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Kellie Machlus @kmachlus.bsky.social · 17/11/2024
Finally- the starter pack we have all been waiting for is here … Hematopoiesis 🎉❤️🩸🦴 So excited to have reached a critical mass of this community on here. 🙌🏻 Let me know if you want to be added!! go.bsky.app/KWdX5w7
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Kellie Machlus @kmachlus.bsky.social · 15/11/2024
Call me biased, but I can't think of a better way to celebrate my first #FluorescenceFriday here than with this beautiful megakaryocyte making proplatelets 😍. Aren't these cells amazing? 🧪🩸 #hemesky
Megakaryocyte making elaborate network of proplatelets. DAPI staining of nuclei and beta-tubulin antibody used to stain cytoskeleton
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Kellie Machlus @kmachlus.bsky.social · 15/11/2024
Hematology and hematopoiesis friends! There’s now a #hemesky feed 🎉 You can tag your posts with this hashtag and pin this feed to your homepage 🥰🩸🧪 bsky.app/profile/did:...
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Kellie Machlus @kmachlus.bsky.social · 15/11/2024
Soooo are we talking about the existential dread or just posting more dog pics? How about dogs with existential dread…
Stella looks very worried
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Kellie Machlus @kmachlus.bsky.social · 14/11/2024
Cold temps and adorable dogs named Charlie are making it very hard to get out of bed these mornings 🥱 But Charlie says- Science isn’t going to do itself! 🧪🩸🔬
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Kellie Machlus @kmachlus.bsky.social · 13/11/2024
Now in my 7th year as a PI (😳) I am understanding that I get so much more sustained happiness and joy from seeing my trainees succeed. Incredible WIP today from Maria, a postdoc on our team. No doubt she is going to do amazing things. 🧪 #hemesky ⭐️
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Kellie Machlus @kmachlus.bsky.social · 29/09/2023
💥MK to Platelet Group Lab Retreat 2023 💥 Cheers to 2 days of creative science, amazing food, tie dye, the best people and late night chats by the fire pit. I’m the luckiest 🥹🫶🏻
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Kellie Machlus @kmachlus.bsky.social · 02/09/2023
Today I had the absolute honor of talking to Arun Rath about our research studying the mystery of how platelets are made🩸🔬 NPR is truly the coolest. What. A. Dream. 🤩🙌🏻 All Things Considered on Boston’s @gbhnews.bsky.social, NPR www.wgbh.org/news/health/...
wgbh.org
'The question that keeps me up at night.' A Boston researcher's quest to understand how platelets ar...
Despite scientists' extensive knowledge of blood, platelets — and what trigger their production — remain largely unknown.
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