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Valerie Soo

@valeriesoo.bsky.social
74 followers 70 following 6 posts

MRC CDA Fellow at Imperial College London | Genotype-phenotype maps, fitness landscapes, Group A Strep, AMR | A #firstgen still learning to navigate the academic landscape

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Reposted by Valerie Soo
Department of Infectious Disease @imperialinfect.bsky.social · 09/06/2026
Researchers CBRB welcomed colleagues from WACCBIP as part of an Imperial Global Connect visit. The event aimed to strengthen international partnerships and advance discovery research in bacterial antimicrobial resistance (AMR). 🔬 www.imperial.ac.uk/news/article...
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Valerie Soo @valeriesoo.bsky.social · 11/06/2026
We are only beginning to understand the breadth of enzyme diversity in the archaeal world. Here's an example of how an archaeon can deploy a phospholipase to kill certain bacteria... www.biorxiv.org/content/10.6...
biorxiv.org
A Bactericidal Phospholipase from Archaea
Archaea kill bacteria, at least on occasion. The molecular underpinnings of these lethal interactions are barely understood. Here, we describe cinquedea, an α/β hydrolase secreted by the halophilic ar...
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Reposted by Valerie Soo
tom-parks.bsky.social @tom-parks.bsky.social · 15/10/2025
Why did severe #StrepA infections in children increase after the pandemic? Our new @jamanetworkopen paper suggests COVID restrictions delayed immunity development in young children. tiny.cc/63vt001
tiny.cc
Immunity to S pyogenes and Common Respiratory Viruses at Age 0 to 4 Years
This cross-sectional study examines changes in immunity to Streptococcus pyogenes and other common respiratory pathogens among young children in 10 European countries after the introduction of nonphar...
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Reposted by Valerie Soo
Imperial MRC DTP @imperialmrcdtp.bsky.social · 29/09/2025
Applications for @ukri.org Medical Research Council funded MRes+PhD studentships in Interdisciplinary Health Sciences at @imperialcollege will open on Tuesday 7 October. www.imperial.ac.uk/multisci-mrc... #PhD #Interdisciplinaryhealthscience #Scholarships
imperial.ac.uk
How to apply
Applications for 2026 entry will open on Tuesday 7 October 2025 at midday (BST) and close at 23:59 (GMT), Tuesday 18 November 2025.
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Reposted by Valerie Soo
Vaughn Cooper @vscooper.micropopbio.org · 27/08/2025
The 2024 rankings of bacterial threats
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Reposted by Valerie Soo
Romain Strock @romainstrock.bsky.social · 15/08/2025
This first-author publication is my… first! Archaea kill bacteria by targeting their Achilles’ heel: peptidoglycan. Big shoutout to @ahocher.bsky.social‬, @valeriesoo.bsky.social‬, Pauline Misson, @tobiaswarnecke.bsky.social‬ and MRC LMS Proteomics. A thread 🔽 journals.plos.org/plosbiology/...
journals.plos.org
Archaea produce peptidoglycan hydrolases that kill bacteria
Archaea regularly interact with bacteria but reports of archaea killing bacteria are very rare. This study shows that many archaea encode peptidoglycan hydrolases, which specifically target bacterial ...
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Reposted by Valerie Soo
PLOS Biology @plosbiology.org · 15/08/2025
Archaea-on-bacteria action! @romainstrock.bsky.social @tobiaswarnecke.bsky.social &co show that many #archaea encode #peptidoglycan hydrolases, which specifically target #bacterial cell walls, experimentally confirming the killing capacity of 2 of these enzymes @plosbiology.org 🧪 plos.io/4lrJBBa
Left: Results of spotting various supernatants onto lawns of Halalkalibacterium halodurans, Phycicoccus endophyticus, and Virgibacillus salexigens. a,b: top fraction (>3 kDa) of supernatant from Haloferax volcanii expressing an intact (a) or catalytic mutant (b) version of Woldo; c,d: bottom fraction (<3 kDa) of supernatant from H. volcanii expressing an intact (c) or catalytic mutant (d) version of Woldo; e: unfiltered supernatant from Halogranum salarium B-1; f,g: top fraction (>3 kDa) of supernatant from H. volcanii expressing (f) Danwoldo or (g) and empty plasmid control; h,i: bottom fraction (<3 kDa) of supernatant from H. volcanii expressing (h) Danwoldo or (i) and empty plasmid control. Top right: Structural overlay of zoocin A from Streptococcus zooepidemicus (UniProt ID: O54308) and Woldo, a candidate PGH from Halogranum salarium B-1 (UniProt ID: J2ZZK6), highlighting homologous M23 domains but divergent cell wall binding domains. TRD: target recognition domain. PG: peptidoglycan. Bottom right: Images of bacterial cells following exposure to H. volcanii supernatants expressing Woldo, Danwoldo or the control (as above). Bacteria are stained using LIVE/DEAD BacLight bacterial viability staining kit with ingress of red dye into bacterial cells indicative of cells with terminally compromised cell wall integrity.
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Valerie Soo @valeriesoo.bsky.social · 15/08/2025
Very happy to see this work published + getting the recognition it deserves! Archaea are very cool + understudied organisms and we are only scratching the surface! Since the preprint last year, we (@romainstrock.bsky.social) have included more evidence of bacteria getting killed by archaeal arsenal.
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Valerie Soo @valeriesoo.bsky.social · 12/07/2025
Putting our deductive, problem-solving, and team-working skills to good use - we had so much fun at the Sherlock Escape Room aaand we escaped in 53 minutes! #teampbp #escaperoom
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Reposted by Valerie Soo
Antoine Hocher @ahocher.bsky.social · 22/03/2025
The MIMIC lab is hiring a Postdoctoral Research Associate to join my team at @Cambridge_Uni! Exploration and engineering DNA-mimicking proteins (wet-lab position.) 🧬 Details: www.jobs.cam.ac.uk/job/50652/ Please get in touch / circulate !
jobs.cam.ac.uk
Research Associate (Fixed Term) - Job Opportunities - University of Cambridge
Research Associate (Fixed Term) in the Department of Genetics at the University of Cambridge.
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Reposted by Valerie Soo
Tiago Costa @tcostalab.bsky.social · 20/02/2025
With @jrpenades.bsky.social, we challenged Google AI co-scientist to generate hypotheses. In just 2 days, it recapitulated our unpublished, experimentally confirmed mechanism for how cf-PICIs spread between bacterial species! @imperialcollegeldn.bsky.social tinyurl.com/3byyaeh2
tinyurl.com
AI mirrors experimental science to uncover a novel mechanism of gene transfer crucial to bacterial evolution
AI models have been proposed for hypothesis generation, but testing their ability to drive high-impact research is challenging, since an AI-generated hypothesis can take decades to validate. Here, we ...
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Valerie Soo @valeriesoo.bsky.social · 12/12/2024
I volunteered at the half-term workshops focused on microbes and the immune system at the Invention Rooms, and I had great conversations with kids and families. Some parents asked sharp questions about why we wanted to become scientists in the first place! www.imperial.ac.uk/news/258715/... [1/2]
imperial.ac.uk
Inspiring the next generation of microbiologists at the Invention Rooms | Imperial News | Imperial College London
Workshops at Imperial's White City campus Invention Rooms have inspired youngsters from the local community to become the microbiologists of tomorrow.
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