iiinova — where your digital self keeps evolving

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Giorgio Seano @giorgioseano.bsky.social · 17/07/2025

🤯 These hybrid cells don’t just look different, they proliferate like they’re on Red Bull and shrug off DNA damage after irradiation. Have they got superhuman repair skills? 🙄 (3/9)

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Giorgio Seano @giorgioseano.bsky.social · 17/07/2025

🛡️ Therefore, these cells are resistant to treatment and are linked to a poorer patient prognosis. Using RNA-seq, nuclear proteome and scChIP-Seq, we discovered their Achilles' heel: a hyperactive nuclear transport system they rely on to import oncogenes like MYC and maintain their state. (4/9)

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Giorgio Seano @giorgioseano.bsky.social · 17/07/2025

🚀 Here's the exciting part: we can target this vulnerability. We hit them with importazole (import blocker) and selinexor (export inhibitor). 🔥 Targeting nuclear import decreases the hybrid cell pool and enhances chemoradiation sensitivity, opening a new therapeutic avenue against GBM. (5/9)

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