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Reposted by Vaibhav Tripathi

Tom Possidente (He/Him) @tom-poss.bsky.social · 31/08/2026

Are there hard boundaries or soft gradients of function between sensory and #working-memory activation in frontal cortex? We show evidence for meso-scale (~1cm) cortical gradients in several frontal ROIs in this bioRxiv preprint. Thread 1/6 #neuroscience #neuroskyence doi.org/10.64898/202...

Process diagram for individual subject ROI gradient vs. boundary model comparison. A) Individual subject p-value map of all visual conditions (WM and SMC) against fixation. The black outline represents the
probabilistic search space for the preSMA ROI while the white outline represents the p<.01 ROI inside the search space for this subject. B) The ROI from A is flattened and the difference of the unsmoothed T-statistics for the WM against SMC and SMC against fixation contrasts are projected. The X-axis is aligned with the axis of greatest change. Gray horizontal gridlines form slices that are 2.2mm in height. C) Data from a single slice is collapsed into 1D, then gradient and boundary models are fit to the data. This is repeated for each slice.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 23/07/2026

and spiritual guidance and blessings of Rev. Acharya Shri Mahashraman whose support made this study possible. Amazingly led by Suruchi Fialoke, Swapnil Prakash, Neha Shekhawat and others!

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 23/07/2026

to see the impact of fasting in long-term and at population-levels. Building a scientific basis of our age-old practices required dedicated effort, time and money. The authors gratefully acknowledge the team at Spiritual Training Research Center, Jain Vishwa Bharti,

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 23/07/2026

Overall mental wellbeing was maintained. The study highlights that such practices undertaken by a large number of practitioners in India and across can be safely studied and could have potential benefits for cardiometabolic health. Further large-scale controlled trials are needed

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 23/07/2026

During the fasting period, transient changes were observed in hepatic enzymes, bilirubin, uric acid, creatinine, and lipid fractions, which were reversible by follow-up (Day-69). hsCRP, HDL, and LDL became better as compared to baseline.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 23/07/2026

Blood was collected before, after, and two months days after the baseline to estimate the impact of various biomarkers. We found that the practitioners observed strict fasting, blood glucose settled after a couple of days, and stabilized - no clinical hypoglycemia.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 23/07/2026

30 days without eating anything!! Praying, meditating, fasting, and doing normal day-to-day activities. We conducted Continuous Glucose Monitoring (CGM) to confirm that fasting was observed. The research was done in strict supervision of doctors and support staff.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 23/07/2026

Excited to share the preprint of a pilot study on the impact of long water fasting on the body. As part of the annual Chaturmas fasting period, 17 Jain practitioners undertook unsupplemented water-only fasting, some for 8 days and six continued for 30 days!! www.medrxiv.org/content/10.6...

medrxiv.org

Real-Time Glycaemic and Metabolic Adaptation During Unsupplemented Spiritual Fasting up to 30 Days: A Self-Controlled Observational Study

Background: Prolonged unsupplemented spiritual fasting (USF), complete caloric abstinence motivated by spiritual practice, is undertaken by many communities worldwide, yet its physiological consequenc...

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 12/06/2026

And lots of thanks to @rademaker.bsky.social for hosting me and to her group for the lovely, engaging scientific discussions.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 12/06/2026

We can do so much cool stuff with layer fMRI and high-resolution imaging using 7T. Frankfurt is pretty this time of year and home to some lovely museums. Really glad that IIT Gandhinagar and DAAD German Academic Exchange Service for giving opportunity to build interesting collaborations.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 12/06/2026

The highlight of the visit was my first scan on a 7 Tesla high-field MRI scanner, which can provide a better look at brain function. Beaming after the success of the scan. Thanks a lot to Dimo Ivanov for all the help with the scanning.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 12/06/2026

Also, met Roland Fleming, who surprisingly was my PhD mentor David Somers' lab mate during his postdoc at MIT. He gave a lovely talk on visual perception of textures.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 12/06/2026

across auditory and visual modalities in prefrontal brain regions. I gave a talk a few weeks ago highlighting the work we have done on sensory-specific and multiple-demand regions in prefrontal and parietal cortices.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 12/06/2026

I’m visiting Frankfurt, Germany, at the Max Planck Society’s Ernst Strüngmann Institute (ESI) as part of the DAAD German Academic Exchange Service Indo-German exchange fellowship, where I’m working with @rademaker.bsky.social's group to investigate sensory and mnemonic codes during working memory

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 03/05/2026

Still to determine if the "chains" in other have such cross modal roles in different networks.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 03/05/2026

The frontoparietal stuff David Somers and colleagues have seen for some time now. We have these interleaved sensory-biased (auditory and vision) and supramodal regions in the PFC. One potential role of chains could be redundancy and integration of cross modal info. www.nature.com/articles/s42...

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 29/04/2026

Overall it was a lovely year with the bright young students, hoping they achieve a lot in the future.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 29/04/2026

in the dlPFC get impacted due to AD, not only because of the prion aggregation but also due to neuroinflammation, metabolic dysruption, and cell structural changes.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 29/04/2026

Yashaswini Ajay explored how the transcriptomic markers in individuals with AD as compared to healthy ppl is expressed in dlPFC(which is usually impacted at a later stage in the disease). She specifically looked at how different brain cells

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 29/04/2026

She found that higher attention computed using SSVEP would translate to faster reaction times on the task, and both alpha and 1/f signals are associated with SSVEP strength. Lots of debugging happened over the past few months before we were able to get the paradigm right.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 29/04/2026

Ruchi Singh worked on understanding how continuous attention task can impact steady state visually evoked potentials in the brain and how they are impacted by intrinsic brain signals like alpha activity and 1/f aperiodic signals.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 29/04/2026

We see interesting behavioral patterns and hope to collect neural data to understand difference in brain rhythms during exploration vs exploitation phases.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 29/04/2026

Rhilee worked on investigating spatial navigation using a maze designed in Unity where the participant had to learn an optimal sequence that can maximize reward. He wanted to see if there are differences in exploratory patterns when the optimal sequence is still being learnt or when it is learned

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 29/04/2026

but we did not find that evidence potentially suggesting a more fixed window length based on age and not training.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 29/04/2026

Rajat Rao worked on understanding how temporal binding window includes visual and auditory info in first person shooter gamers and non-gamers. The hypothesis was that gamers with their experience of rapidly including sensory stimuli across modalities would have different temporal binding window

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 29/04/2026

His work suggests that AI models more grounded in biological models would be more real-like in their interactions with users.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 29/04/2026

Arya Shah, honorary member of the lab, who worked with me on NeuroAI based projects since last semester investigated how Vision Language Models (VLMs) which are not as aligned to early visual cortices tend to be more sycophantic in nature that is they would agree with the user even if they are wrong

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 29/04/2026

..suggesting that ANNs have a long way to go before they can truly mimic biological vision. His paper got accepted in the ICLR 2026 HCAIR workshop on Cognitive Interpretability of AI models.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 29/04/2026

Arnav Shakya worked on visual perception in humans and Deep Neural Networks especially how we do filling-in of hidden objects. He found through psychophysical investigation that our visual system completes objects which are occluded but DNNs fail to do so..

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 29/04/2026

Had a great time with the batch of graduating Master's students from Integrative Neuroscience & Technology Lab at IIT Gandhinagar at their farewell dinner and bowling. It was a pleasure having them in the group and working on the various aspects of human cognition and neurobiology.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 19/04/2026

Agreed. It could stem from the fear of maths in students who opt for psychology or biology as a major. Those comfortable with math may incline towards more quant-heavy fields. We need both.

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Reposted by Vaibhav Tripathi

Sebastian Bae @sebastianbae.bsky.social · 05/04/2026

Current status.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 03/04/2026

Video link:https://www.youtube.com/watch?v=0xtr3w3WXhs

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 03/04/2026

She along with her colleagues have developed tools like WHATNET that can help compare the networks reported in a study with various atlases. Hopefully the community comes in board with such attempts to make it easier to talk amongst each other.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 03/04/2026

And compiling literature that brings about these networks together becomes harder still. What Prof. Uddin is trying to do is make it cohesive for the cognitive neuroscience community to have a consistent language to talk amongst each other whenever these networks are concerned.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 03/04/2026

Having worked in the field of large-scale brain networks for a few years, it was always confusing to see different names used by various groups for similar brain networks. The same network could be called Salience, Ventral Attention or Insula network or something else.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 03/04/2026

It was exciting to host an online Cognitive and Brain Sciences seminar at the Indian Institute of Technology Gandhinagar by @lucinauddin.bsky.social where she talked about her recent efforts to create a universal taxonomy of functional brain networks.

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Reposted by Vaibhav Tripathi

Tom Possidente (He/Him) @tom-poss.bsky.social · 27/03/2026

My first first co-author paper! Big thank you to @vaibhavtripathi.bsky.social, Joe McGuire, and @profsomers.bsky.social. Cool to take a deeper look at how different WM networks interact at resting state and during WM tasks, and learned a lot of new analysis techniques along the way.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 24/03/2026

Or maybe just like patents, we renew papers if they still hold valid after every x years.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 19/03/2026

Hoping for further discussions and collaborations on the central role of thalamus in cognition. Video link: www.youtube.com/watch?v=TsPP...

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 19/03/2026

the contents of consciousness. He demonstrated robust modeling attempts for how the core and matrix nuclei project to the cerebral cortex and able to control the dynamics of the brain from wakefulness to dreams to sleep. Loved the extent of work covered in his talk.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 19/03/2026

It was great listening to @macshine.bsky.social for our online Cognitive and Brain Sciences Seminar @cogsiitgn.bsky.social. Mac talked about the "Thalamic Contributions to the State and Contents of Consciousness". He talked about the integral role thalamus plays in defining the brain states and

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 19/03/2026

Lots of thanks to David Somers @profsomers.bsky.social and Joseph McGuire for their amazing mentorship.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 19/03/2026

So glad to see this paper come out. Amazingly led by @tom-poss.bsky.social. Auditory working memory reconfigures task connectivity utilizing more supramodal and visual regions. Had a great time working on this data collection, the task design was challenging but learnt so many things in the process.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 16/03/2026

She developed a new coil and headphones and then studied the development of different brain regions related to various aspects of visual and auditory processing. The students appreciated the depth and extent of the work.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 16/03/2026

Infants are particularly hard to study using fMRI, which allows for an unprecedented look into the functioning of the brain. MRI is noisy, and not super comfortable for infants who tend to move a lot, thus need for better tools.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 16/03/2026

It was a pleasure hosting @kosakowski.bsky.social for the Cognitive and Brain Sciences Seminar at IIT Gandhinagar. Heather talked about her pioneering work on studying perception and development in infants using fMRI.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 24/02/2026

He highlighted the key aspects of studying aging, the limitations of developing brain age prediction tools, as it is aging that we are keen on studying and not only the age of an individual (which can always be asked). It was a brilliant talk and lovely interaction.

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Vaibhav Tripathi @vaibhavtripathi.bsky.social · 24/02/2026

Max talked about his recent paper in Nature Aging on DunedinPACNI: a method to understand brain age and aging, and how they used the Dunedin dataset to create this useful tool to understand how people age.

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