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Kalev Freeman

@uvmtraumalab.bsky.social
969 followers 2.4K following 157 posts

Can we resuscitate damaged endothelium after injury? | Physician-scientist studying small blood vessels and trauma physiology at the University of Vermont 🚑 | Father, dog-lover, snow-sport enthusiast, and bluegrass fiddle player 🎻

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Kalev Freeman @uvmtraumalab.bsky.social · 22/02/2026
Laupäev on saunapäev #sauna #vermont
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Kalev Freeman @uvmtraumalab.bsky.social · 25/01/2026
Using cookie cutters to watch beautiful ice crystals form! ❄️❄️❄️ #Brrrrrr #ScienceIsCool #STEM #Vermont
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Kalev Freeman @uvmtraumalab.bsky.social · 24/01/2026
Breathtaking beauty with Camel’s Hump towering over the snow covered hills and Mansfield socked in by clouds to the North. It’s been an amazing #ski season already, and the next big storm is just around the corner … ❄️❄️❄️ #Vermont #Greenmountains #Skiing #LetItSnow
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Kalev Freeman @uvmtraumalab.bsky.social · 24/01/2026
Great science, great people, great conversations. Sharing our work and some laughs with our research team and senior leadership at the poster session in Stowe. This is what a thriving research community looks like. 🧪🏔️ @K8Tracy.bsky.social @UVMLarnerMed.bsky.social @uvmvermont.bsky.social
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Kalev Freeman @uvmtraumalab.bsky.social · 07/01/2026
How do you explain to your kid why one of his hero’s #BélaFleck cancelled his #Kennedycenter performances? We don’t do art for the money, or for political gain. The focus should be on the music. Thank you Béla for doing the right thing and being a role model for the next generation. #music #art
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Manuel F. Navedo @mfnavedo.bsky.social · 09/12/2025
Great way to start the final month of the year with the publication of this collaborative work on how dopamine regulates L-type channels in #neurons. www.science.org/doi/10.1126/... And we got the cover!!! @ucdavis.bsky.social, @ucdavishealth.bsky.social
science.org
Stimulation of Ca2+ channel CaV1.2 activity by dopamine signaling augments spatial working memory
Dopamine-induced phosphorylation of an L-type Ca2+ channel supports working memory in mice.
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Osama Harraz @osamaharraz.bsky.social · 18/12/2025
🧵Excited to share our work with the Bracko @bloodflowlab.bsky.social lab published in Alzheimer's & Dementia @alzassociation.bsky.social : Systemic Piezo1 activation improves cerebrovascular function in Alzheimer’s disease 🔗https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71016
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Kalev Freeman @uvmtraumalab.bsky.social · 07/12/2025
#Skijoring #SkiVermont #Vermont #Ski #Skiing #Skisky #Dogs #Dogsofbkuesky
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Deb Houry @drdebhoury.bsky.social · 22/11/2025
My thoughts on ABC news- Scientists, not political appointees, should be who advises the public on clinical guidance. RFK needs to meet with CDC career leaders and learn about the agency's responses to outbreaks and overall programs vs directing CDC website changes based on ideology not science
abcnews.go.com
Video Former CDC chief on agency webpage saying autism, vaccines link ignored
Dr. Debra Houry, who resigned from her position as chief medical officer of the CDC in 2025, called the change on the CDC’s website "disturbing."
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Kalev Freeman @uvmtraumalab.bsky.social · 08/11/2025
Totally! And the left side of this photo epitomizes pathological narcissist behavior. Great photo.
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Kalev Freeman @uvmtraumalab.bsky.social · 03/11/2025
Study abroad in the #Galápagos Islands for spring break 2026! Earn 3 credits & travel to spectacular locations with #UVM faculty for hands-on exploration of the unique biodiversity in #Ecuador. Spots are limited, inquire today at goabroad.uvm.edu/index.cfm?Fu... @uvmvermont.bsky.social
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Kalev Freeman @uvmtraumalab.bsky.social · 31/10/2025
🎃👻💀
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Kalev Freeman @uvmtraumalab.bsky.social · 18/10/2025
#NoKings #Resist #Waterbury #Vermont
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Kalev Freeman @uvmtraumalab.bsky.social · 18/10/2025
#NoKings #Resist #Vermont #GreenMountains
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Kalev Freeman @uvmtraumalab.bsky.social · 29/09/2025
In their juvenile stage, terrestrial Eastern Newts (Notophthalmus viridescens), also known as red efts, produce tetrodotoxin, the same NaV channel blocking-neurotoxin as pufferfish. The striking coloration is an aposematism. #Toxicology #toxsky #emsky #NeuroSky #ionchannels #electrophysiology
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Kalev Freeman @uvmtraumalab.bsky.social · 27/09/2025
Best friends #DogsofBluesky #BorderCollies #Vermont
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Kalev Freeman @uvmtraumalab.bsky.social · 07/09/2025
Chillin’ out! Even border collies need to take a break sometimes. #bordercollies #dogsofbluesky #chillaxing #vermont
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Kalev Freeman @uvmtraumalab.bsky.social · 31/08/2025
Thank you, Deb, for standing up for science and health! We have your back. 💪 @acepnation.bsky.social #EMSky #EMedSky #MedSky
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Kalev Freeman @uvmtraumalab.bsky.social · 28/08/2025
Emergency medicine physician-scientist superstar Debra Houry resigned her post as Chief Medical Officer of the CDC yesterday, along with other top officials. This is terrible news. American public health is being completely gutted by this administration. #emsky #emedsky #medsky #nih #cdc
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Jeremy Berg @jeremymberg.bsky.social · 24/08/2025
New York Times story with profiles of researchers whose grants were terminated. [Gift Link] www.nytimes.com/2025/08/24/o...
nytimes.com
Opinion | America First? Not When It Comes to Your Health.
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Manuel F. Navedo @mfnavedo.bsky.social · 15/08/2025
The official release of our manuscript examining arterial myocyte Panx1 role in diabetic vascular dysfunction is out! Massive effort to uncover new mechanisms underlying vascular disease. Power of science! @ucdavis.bsky.social, @ucdavispharm.bsky.social www.ahajournals.org/doi/10.1161/...
ahajournals.org
Arterial Myocyte Pannexin 1 Channel Controls Vascular Reactivity in Diabetic Hyperglycemia | Circulation Research
BACKGROUND: Diabetic hyperglycemia promotes vasoconstriction by activating an ATP-dependent P2Y11L (P2Y11-like receptor)/AC5 (adenylyl cyclase 5)/AKAP5 (A-kinase anchoring protein 5)/PKA (protein kina...
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Kalev Freeman @uvmtraumalab.bsky.social · 16/08/2025
Congrats!
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Kalev Freeman @uvmtraumalab.bsky.social · 16/07/2025
VIP guests visiting the lab and my all-star team of scientists today. #MedSky #AcademicSky #Scienceiscool #UVMLarnerMed
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Hakeem Jeffries @hakeem-jeffries.bsky.social · 03/07/2025
Just took to the House Floor to speak in support of a country where everyone can afford to live the good life. And in strong opposition to Trump’s One Big Ugly Bill that is devastating to everyday Americans. We will not be silenced. www.youtube.com/live/3pbFrch...
youtube.com
House Democrats are voting HELL NO
YouTube video by Rep. Jeffries
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Kalev Freeman @uvmtraumalab.bsky.social · 03/07/2025
Another reason why I love #Vermont: Our first-of-its kind law that bars schools from using social media platforms to communicate or engage in academic and extracurricular activities with students, along with banning cell phones in schools. #Bipartisan #Publicpolicy #Goodideas #Greenmountains
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Kalev Freeman @uvmtraumalab.bsky.social · 21/06/2025
Good morning! #Vermont #GreenMountains #BorderCollies #Dogs #Dogsofbluesky
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Kalev Freeman @uvmtraumalab.bsky.social · 16/06/2025
No Kings! Hands off our medical research. What they are trying to NIH is totally illegal and democracy will prevail. #MedSky #EMSky #NIH 🧪 Judge orders NIH to restore hundreds of grants cut under Trump | Science | AAAS www.science.org/content/arti...
science.org
Judge orders NIH to restore hundreds of grants cut under Trump
William Young calls terminations illegal, berates agency for discrimination
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The Larner College of Medicine @uvmlarnermed.bsky.social · 16/06/2025
Kalev Freeman, M.D., emergency medicine physician at the UVM Medical Center and #UVMLarnerMed assistant professor of emergency medicine attends the #SHOCKCON25 with UVM pre-med and grad students @uvmvermont.bsky.social
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Kalev Freeman @uvmtraumalab.bsky.social · 14/06/2025
Army: Stopping Kings Since 1776🇺🇸
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Kalev Freeman @uvmtraumalab.bsky.social · 10/06/2025
Yep, I saw an identical letter sent to one of my colleagues today. Crazy. At least, you can still list it on your CV! 😊
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Gregg Gonsalves @gregggonsalves.bsky.social · 09/06/2025
Courage. Now more than ever. These NIH staffers just stood up to Trump, RFK Jr., Bhattacharya. We need to have their backs. The administration will come for each of them, one and all now. apnews.com/article/nih-...
apnews.com
NIH scientists go public to criticize Trump's deep cuts in public health research
Scores of National Institutes of Health researchers and staffers have come forward to send their Trump-appointed leader a letter challenging policies they say undermine the NIH mission.
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Kalev Freeman @uvmtraumalab.bsky.social · 10/06/2025
Now they are purging top scientific advisors to the NIH. This same letter went out to others on the committee today. #NIH #MedSky #fundscience
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Kalev Freeman @uvmtraumalab.bsky.social · 07/06/2025
It’s really buzzing around here today! 🐝 #Vermont #GreenMountains #Bumblebee
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The Larner College of Medicine @uvmlarnermed.bsky.social · 04/06/2025
In their joint blog post (link below), #UVMLarnerMed alumni Dr. Vinh Le, M.D.’25, and his father, Dr. Phil Le, M.D.’90, reflect on what led each of them to study medicine. Dr. Vinh Le's research mentor is @marycushmanmd.bsky.social
uvmlarnermedblog.com
Father and Son: Inspiring Med Student Journeys at Larner
Discover Vinh Le's inspiring journey from medical student to researcher at Larner, shaped by his father's legacy and a passion for healthcare.
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Kalev Freeman @uvmtraumalab.bsky.social · 02/06/2025
It’s great to be back in Boston for 48th Annual Conference on Shock, with talented pre-med and grad students from @uvmvermont.bsky.social. Continuing our tradition of sushi dinner with the lab and friends at the meeting. #SHOCKCON25 #UVMLarnerMed
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Kalev Freeman @uvmtraumalab.bsky.social · 02/06/2025
Cold stored #platelets win the race! They can be given much faster during trauma resuscitation because they can be kept near point of care. Great work from Macky Neal and team @pittsurgery.bsky.social #SHOCKCON25 #platelets #trauma #transfusion #EMsky #MedSky 🧪
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Kalev Freeman @uvmtraumalab.bsky.social · 15/05/2025
“Lab-van” conversion! UVM @uvmlarnermed.bsky.social mobile lab is bringing science to students in rural schools across #Vermont. #scicomm #scienceiscool #stem #medsky #UVMLarnerMed #UVMFutureDocs #LarnerResearch #LarnerFaculty
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Kalev Freeman @uvmtraumalab.bsky.social · 10/05/2025
The DOGE chainsaw just hit a huge spike! An emergency ruling by a federal judge in California has temporarily halted the illegal overhaul of the federal government including attacks #NIH & #NSF. Resistance works, but our legal system takes time. Hang in there folks.
media.tenor.com
a man holding a briefcase with the words oh yes written below him
ALT: a man holding a briefcase with the words oh yes written below him
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Kalev Freeman @uvmtraumalab.bsky.social · 10/05/2025
The DOGE chainsaw just hit a huge spike! Emergency ruling by federal judge in California has temporarily shut down the illegal overhaul of the federal government, including attacks on NIH and NSF.
media.tenor.com
a man holding a briefcase with the words oh yes written below him
ALT: a man holding a briefcase with the words oh yes written below him
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Kalev Freeman @uvmtraumalab.bsky.social · 02/05/2025
What a week. At least we only have 1359 days left with this administration.
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Kalev Freeman @uvmtraumalab.bsky.social · 02/05/2025
Congrats to postdoc Grace Bonson & team! And thanks to our sponsors and the Shock society for both the trainee award at the Annual Conference on Shock and the opportunity to publish in @shockjournal.bsky.social. This was made possible by funding from #NIH #NIGMS #NHLBI. #UVM #UVMLarnerMed 5/n
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Kalev Freeman @uvmtraumalab.bsky.social · 02/05/2025
Histone levels are increased in the blood in #trauma and #sepsis. We found that blocking the scramblase TMEM16f prevented pro-thrombotic activation of endothelial cell plasma membranes caused by histone exposure. Could this be a therapeutic target? #ImmunoSky #EMSky #Medsky #Scicomm 4/n
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Kalev Freeman @uvmtraumalab.bsky.social · 02/05/2025
TMEM16f is also an #ionchannel. Blocking it prevented endothelial cell calcium release produced by histone exposure. 3/n
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Kalev Freeman @uvmtraumalab.bsky.social · 02/05/2025
Scott’s syndrome is considered a #platelet disease caused by defects in TMEM16f, but knocking this out in platelets does not cause bleeding problems. In contrast, we found that knocking out TMEM16f in #vascular endothelial cells prevents normal #bloodclotting. 2/n #Immunosky #EMSky #Medsky 🧪
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Kalev Freeman @uvmtraumalab.bsky.social · 02/05/2025
👀 New paper alert! @devdoot.bsky.social. The #endothelial cell scramblase TMEM16f is critical for #hemostasis, independent of platelets. This explains bleeding in Scott's syndrome. #ionchannels #endothelium #bloodvessel #hemostasis #NIGMS #NHLBI #scicomm 1/n pubmed.ncbi.nlm.nih.gov/39874534/
pubmed.ncbi.nlm.nih.gov
ENDOTHELIAL-SPECIFIC KNOCKOUT OF THE SCRAMBLASE TMEM16F IMPAIRS IN VIVO CLOT FORMATION - PubMed
Objective: Loss of function of the phospholipid scramblase (PLS) TMEM16F results in Scott syndrome, a hereditary bleeding disorder generally attributed to intrinsic platelet dysfunction. The role of T...
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Kalev Freeman @uvmtraumalab.bsky.social · 02/05/2025
So nothing will be awarded until they issue a new policy in September. If you have a foreign collaborator on a project, need to wait until then to see if you can revise the structure OR remove foreign collaborator & redistribute extra funds to collaborators / new domestic subawards. #medsky #NIH 🧪
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Kalev Freeman @uvmtraumalab.bsky.social · 30/04/2025
University of Vermont @uvmvermont.bsky.social students in the lab, working hard to wrap up their outstanding research work for the end of the term. #vermont #uvmlarnermed #premed #medsky #academicsky
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Kalev Freeman @uvmtraumalab.bsky.social · 30/04/2025
@dablab.bsky.social team discovered that an #ionchannel - TRPC3 - drives the myogenic response in transitional #pericytes but not smooth muscle cells, making it a target to rescue abnormal #cerebrovascular flow in #neurodegeneration. #neuroskyence #scicomm #MedSky 🧪 www.science.org/doi/10.1126/...
science.org
Increased luminal pressure in brain capillaries drives TRPC3-dependent depolarization and constriction of transitional pericytes
Blood flow into the cerebral microvasculature is regulated by TRPC3-dependent constriction of transitional pericytes.
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Kalev Freeman @uvmtraumalab.bsky.social · 28/04/2025
Abigail Howard, senior in biomedical engineering, presented her work at the @uvmvermont.bsky.social SRC. She used FACS to understand #vascular #endothelial cell inflammatory responses that drive trauma induced coagulopathy. Stay tuned for paper in preparation from this team! #EMSky #Immunosky
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