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Ary Shalizi

@unsequenced.bsky.social
181 followers 197 following 781 posts

Biologist, book nerd, parent, hype skeptic in no particular order. Phenotypic screening for cell and chemical biology. Also, random book reviews at link. unsequenced.life

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Ary Shalizi @unsequenced.bsky.social · 03/10/2026
Today my 11yo fully grasped the concept of inflation. Visiting home to mark 1y since my mom passed, found my old LoTR paperbacks. Disgusted, she asks "why is the paper so... yellow?!" "Because these are 42 years old." "Ugh, so gross." "Yeah, look: 1984 edition, $3" "You could buy a book for $3?" 💙📚
Image of the 1984 balantine edition paperback trilogy of The Lord of the Rings. Sky blue Fellowship of the Rings, green The Two Towers, red The Return of the King.Detail of Return of the King cover showing retail price of $3 ($2.95).
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Reposted by Ary Shalizi
Coleen Murphy @ctmurphy1.bsky.social · 02/10/2026
Wow. I really appreciate this review! (So detailed and well-written)
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Ary Shalizi @unsequenced.bsky.social · 02/10/2026
Thank you! I try to pick a different topic for summer reading every year, and this year it was books about aging. Your book is the one I’m going to recommend to people who ask me about what I do at work…
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Ary Shalizi @unsequenced.bsky.social · 02/10/2026
2026 book thread, pt. 23 Back to the biology of aging with what is, hands down, the best book about the biology of aging: “How We Age,” by @ctmurphy1.bsky.social. Lucidly written, meticulously researched, hype-free. #💙📚, #WritingCommunity
unsequenced.life
Bless the Maker, and His Water
Coleen T. Murphy’s lucidly written and meticulously researched How We Age wins Critical Aging Summer. Comprehensive but still accessible, and free of unnecessary hype.
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Ary Shalizi @unsequenced.bsky.social · 25/09/2026
This time, I had so many open tabs — from 66 year old warnings about AI doom, to 20 years of claims that robots are about to do ALL the laboratory science — I gave them in their own entry. @chorye.bsky.social, if you want more of these for your automation classes, lmk!
unsequenced.life
One day, I’ll have time to read all of it?
Open tabs get their own post today. This approach to note taking might become a regular feature. It’s positively cathartic to close tabs this way.
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Ary Shalizi @unsequenced.bsky.social · 25/09/2026
Every change of season, I like to take stock of what's been happening in the world, what I've been reading, and make a list of tabs I'll get back to and read, I swear...
unsequenced.life
Books to read while the world burns: Sukkot 2026
Summer is always a mess. A mess of camps, with their shifting pick-up and drop-off times, of travel and lab and family commitments, and a collapsing republic. But books provide some welcome groundi…
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Ary Shalizi @unsequenced.bsky.social · 24/09/2026
Cell culture is hands on/brain off, and before podcasts I'd listen to the classes I didn't get to in undergrad. One UC course on the History of Information changed my ideas about information, and this 1965 thing about international paper sizes reminded me how physical an abstract concept can be.
Text on transition to international paper sizes in the UK, from a 1965 edition of Nature
THe proposed change-over to the metric system in Britain will necessarily take a long time for full realization and it will pose many practical problems, both industrial and domestic. Not the least of thoso is the effect on paper sizes and printing, where tradition is likely to die very hard. If the proposed scheme of the metric-based International Paper Sizes' is adoptod, it will completely revolutionize the present practice of the printing and publishing trades, with consequent repercussions in commerce, professional and private customs, particularly where books, pamphlets, display leaflets, stationery and envelopes are concerned, to mention only a few of the items involved. The keyword behind the conception of 'International Paper Sizes', as it is known, is simply rationalization. It means ... the introduction of a completely new range of paper sizes, from small to large, each based upon a metric measure and each related, in logical sequence and proportion, to the rest of the range"
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Ary Shalizi @unsequenced.bsky.social · 24/09/2026
Came here to say this!
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Ary Shalizi @unsequenced.bsky.social · 23/09/2026
2026 book thread, pt 22. Taking a break from the biology of aging with a suggestion iof my daughter's: Chelsea Sedoti's backwoods mystery, "Tell Me What Really Happened." #booksky #WritingCommunity
unsequenced.life
Ok, Zoomer?
Chelsea Sedoti’s Tell Me What Really Happened is a kinetic high school mystery that hits all the hot issues: Guns, race, class, social media… … and Sasquatch!
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Ary Shalizi @unsequenced.bsky.social · 22/09/2026
Bring back the triune brain. Make Sagan accurate again!
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Ary Shalizi @unsequenced.bsky.social · 18/09/2026
2026 book thread, pt 21. So, I read “Outlive” because it was relevant to my summer project of “popular books about aging.” For a book whose central message boils down to “better living through KPIs,” it was … better than I expected? #booksky #WritingCommunity
unsequenced.life
Death of the author
Longevity gurus are unavoidable, but Peter Attia and Bill Gifford’s Outlive was better than I expected. Leaving aside the author’s personal failings, it does a good job of explaining co…
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Ary Shalizi @unsequenced.bsky.social · 17/09/2026
Why does this have the form factor of a 96-well assay plate?
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Ary Shalizi @unsequenced.bsky.social · 14/09/2026
I mean, ”we’ve got to slow down” is a banger way to stop spending billions on training marginally better models, and make your business appear more sustainable. Maybe I am too cynical?
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Ary Shalizi @unsequenced.bsky.social · 14/09/2026
“AI leaders identify face-saving excuse to dramatically reduce cash burn.”
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Ary Shalizi @unsequenced.bsky.social · 11/09/2026
2026 book thread, pt. 20. Margareta Magnusson's charming essay collections embrace the role of community and connection for healthy aging. Also, it helps to have an intact welfare state... #booksky
unsequenced.life
Swedish massage
Margareta Magnusson’s delightful diptych about growing old and letting go shows that healthy aging is all about attitude… if you’re lucky enough to do it in a robust welfare state.
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Ary Shalizi @unsequenced.bsky.social · 11/09/2026
Forgot to add #booksky when I posted last week. 2026 book thread, pt. 19. "Cracking the Aging Code" is a reminder that you don't need AI to produce slop. The central argument is that aging is adaptive and arose via group selection, but we should still try to stop it, because getting old is scary.
unsequenced.life
I have no need of that hypothesis
Have we got aging all wrong? Josh Mitteldorf and Dorion Sagan sure think so! Cracking the Aging Code is a book whose central argument boils down to “aging is good for the species and the plan…
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Ary Shalizi @unsequenced.bsky.social · 11/09/2026
After soccer practice today, the 8yo says out of nowhere: “Dad, I have an idea! Boba [long pause]… … Topped with cotton candy! I bet they have it in New York.”
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Ary Shalizi @unsequenced.bsky.social · 10/09/2026
All of which can, I suppose, be handled by a CRO, because he definitely ain't doing that stuff in a garage. But it seems exceedingly reckless. How is he disposing of his chemical waste? He's using a box fan for ventilation, ffs!
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Ary Shalizi @unsequenced.bsky.social · 10/09/2026
OMG, he has another lead compound, PAC-832. And it appears that the other 6/7ths of the original thread about PAC-3-3-10 are additional supporting data, like concentration of compound in the brain and open-field behavior tests.
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Ary Shalizi @unsequenced.bsky.social · 10/09/2026
I am so curious about the other 6/7ths of this thread. Does he share a structure? Is there some analytical chemistry to determine purity? What, exactly, does he mean by “improved”?
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Ary Shalizi @unsequenced.bsky.social · 08/09/2026
I’m running with it. Everyone I know who goes to Burning Man was in their 20s 30 years ago…
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Ary Shalizi @unsequenced.bsky.social · 08/09/2026
“Boomers and GenX ruin movement they started.”
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Ary Shalizi @unsequenced.bsky.social · 04/09/2026
2026 book thread, pt. 19. "Cracking the Aging Code" is a good reminder that people can produce slop without AI. The central argument is that aging is adaptive and arose via group selection, but we should still try to stop it, because getting old is scary.
unsequenced.life
I have no need of that hypothesis
Have we got aging all wrong? Josh Mitteldorf and Dorion Sagan sure think so! Cracking the Aging Code is a book whose central argument boils down to “aging is good for the species and the plan…
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Ary Shalizi @unsequenced.bsky.social · 03/09/2026
Not Monsieur Fève?
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Ary Shalizi @unsequenced.bsky.social · 01/09/2026
Very disappointed in this episode. I listen exclusively to hear them dunk on Oberlin, and there was no dunking on Oberlin.
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Ary Shalizi @unsequenced.bsky.social · 27/08/2026
Overcast does a decent automated transcription.
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Ary Shalizi @unsequenced.bsky.social · 27/08/2026
@alondra.bsky.social on @adambecker.bsky.social’s podcast. overcast.fm/+ABWrNFAPG9U
overcast.fm
Episode 18: Science Policy, with Alondra Nelson — Dreaming Against the Machine
This week, Adam talks with Alondra Nelson, sociologist and former head of the White House Office of Science and Technology Policy under Joe Biden. They talk about the destruction of scientific researc...
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Ary Shalizi @unsequenced.bsky.social · 16/08/2026
I can assure you i am not a bot. I’m just a biologist who is required to evaluate internal tools as part of my job.
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Ary Shalizi @unsequenced.bsky.social · 16/08/2026
?
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Ary Shalizi @unsequenced.bsky.social · 16/08/2026
I feel like long-term, research will suffer for the missed connection. Researchers will crrtainly lose a bit of joy.
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Ary Shalizi @unsequenced.bsky.social · 16/08/2026
Kind of like going to the library to find one book, and checking out something you found shelved nearby. I can understand people saying it “saves time,” because it can get you to a much narrower list of references that can be quickly verified than more traditional search.
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Ary Shalizi @unsequenced.bsky.social · 16/08/2026
My experience testing publicly available chatbots for research purposes has found them very sensitive to phrasing, in a counterproductive way. You also lose the joy of finding things that are not directly relevant to your original question, but still interesting orthogonal areas to explore.
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Ary Shalizi @unsequenced.bsky.social · 16/08/2026
Now, you still have to read the papers. Because the real benefit of finding the studies is the bibliographies, which can point you more reliably to related research. And this is a very narrowly focused research tool.
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Ary Shalizi @unsequenced.bsky.social · 16/08/2026
Using the chatbot interface, I used a single natural language prompt along the lines of “find me studies that looked at __,” and got back a bullet list with links back to pubmed. The chatbot query found all the same studies in a few minutes.
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Ary Shalizi @unsequenced.bsky.social · 16/08/2026
From those 30, I found about a dozen relevant papers for each research question. It took a few hours to get to the shortlist of genuinely relevant work. And I still have to read the papers, which is the actually time consuming part.
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Ary Shalizi @unsequenced.bsky.social · 16/08/2026
I had a couple of relatively obscure questions that I already knew the relevant studies for. To find those by old-school pubmed search, I had to go through search output of a bit more than 100 citations for each question. Based on title, I found 30 studies where I read the abstracts.
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Ary Shalizi @unsequenced.bsky.social · 16/08/2026
So I’ve had to test this use case out for work, and this is how it shook out for me… and this was using an in house natural language query system for pubmed, not an off-the-shelf tool like Claude or ChatGPT.
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Ary Shalizi @unsequenced.bsky.social · 15/08/2026
The script for this video was used without permission.
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Ary Shalizi @unsequenced.bsky.social · 15/08/2026
The script for this video was used without the author’s permission.
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Ary Shalizi @unsequenced.bsky.social · 14/08/2026
I work in drug discovery, and mine was after our daughters’ preschool closed in March 2020. My wife asked if the pandemic would really be done by summer like the news was saying. I said “no way, at least 500 days to develop and widely distribute anything effective enough.”
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Ary Shalizi @unsequenced.bsky.social · 14/08/2026
YT served me this video, which has nearly 1M views. The audio is just the content creator reading a 24-year-old book review, word-for-word. The author of that review is still alive, and the content creator never asked for permission to use the text!
Screengrab of video thumbnail for YT creator MQTate’s video, “The Most Arrogant Science Book Ever Written.” The script for the video is a 2002 review of Wolfram’s “A New Kind of Science,” from the website bactra.org, used without the author’s permission.
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Ary Shalizi @unsequenced.bsky.social · 13/08/2026
A physicist also said “If I could explain it to the average person, it wouldn’t have been worth the Nobel prize.” Always trying to have it both ways, the physicists!
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Ary Shalizi @unsequenced.bsky.social · 13/08/2026
Laboratory automation does not make science easier. It makes it a different kind of difficult.
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Ary Shalizi @unsequenced.bsky.social · 11/08/2026
Would love to know from anyone with experience in recovering government records if a FOIA request is the right way to try to get access to previously public lectures, or if there is another method, or if those lectures are just gone now? Thanks! 3/3
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Ary Shalizi @unsequenced.bsky.social · 11/08/2026
but the videocast site for NIH has been changed and all lectures prior to 2012 are gone. There was a temporary videocast-b website, which had the old lecture directory, but the recordings were no longer publicly available, and the alternate site now seems to have been deactivated. . : 2/n
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Ary Shalizi @unsequenced.bsky.social · 11/08/2026
Hi, I'm looking for some basic advice on filing a #FOIA request. The NIH used to post their Wednesday Afternoon Lecture Series on a public website, with lectures dating back to the late 1990s. I've been planning a research project on how scientific presenting styles have changed, . : 1/n
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Ary Shalizi @unsequenced.bsky.social · 07/08/2026
2026 book thread, pt. 18. An ambitious but flawed polemic about how Americans approach health and aging and so much more. Barbara Ehrenreich’s “Natural Causes.” #booksky
unsequenced.life
Ok, boomer
Book six of Critical Aging Summer is a cranky polemic about how attempting to do anything for your health is pretty much pointless, because you’ll die no matter what you do. Barbara Ehrenreic…
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Ary Shalizi @unsequenced.bsky.social · 01/08/2026
My Italian mom used to say “inshallah” all the time. She was an atheist who married a non-practicing muslim and just preferred it as an alternative to “let’s hope so.”
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Ary Shalizi @unsequenced.bsky.social · 17/07/2026
This joke is historically inaccurate…
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Ary Shalizi @unsequenced.bsky.social · 17/07/2026
2026 book thread, pt. 17 An actually interesting, well written book about aging, and how different it looks across phyla: Steven Austad's "Methuselah's Zoo." 🧪 #booksky
unsequenced.life
Achieving organism
Steven Austad’s delightful Methuselah’s Zoo is worth reading even if you don’t care about aging or longevity. It’s an engrossing work of natural history, detailing the very …
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