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Ary Shalizi

@unsequenced.bsky.social
181 followers 199 following 790 posts

Biologist, book nerd, parent, hype skeptic in no particular order. Phenotypic screening for cell and chemical biology. Also, random book reviews at link. unsequenced.life

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Ary Shalizi @unsequenced.bsky.social · 03/10/2026
Today my 11yo fully grasped the concept of inflation. Visiting home to mark 1y since my mom passed, found my old LoTR paperbacks. Disgusted, she asks "why is the paper so... yellow?!" "Because these are 42 years old." "Ugh, so gross." "Yeah, look: 1984 edition, $3" "You could buy a book for $3?" 💙📚
Image of the 1984 balantine edition paperback trilogy of The Lord of the Rings. Sky blue Fellowship of the Rings, green The Two Towers, red The Return of the King.Detail of Return of the King cover showing retail price of $3 ($2.95).
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Ary Shalizi @unsequenced.bsky.social · 24/09/2026
Cell culture is hands on/brain off, and before podcasts I'd listen to the classes I didn't get to in undergrad. One UC course on the History of Information changed my ideas about information, and this 1965 thing about international paper sizes reminded me how physical an abstract concept can be.
Text on transition to international paper sizes in the UK, from a 1965 edition of Nature
THe proposed change-over to the metric system in Britain will necessarily take a long time for full realization and it will pose many practical problems, both industrial and domestic. Not the least of thoso is the effect on paper sizes and printing, where tradition is likely to die very hard. If the proposed scheme of the metric-based International Paper Sizes' is adoptod, it will completely revolutionize the present practice of the printing and publishing trades, with consequent repercussions in commerce, professional and private customs, particularly where books, pamphlets, display leaflets, stationery and envelopes are concerned, to mention only a few of the items involved. The keyword behind the conception of 'International Paper Sizes', as it is known, is simply rationalization. It means ... the introduction of a completely new range of paper sizes, from small to large, each based upon a metric measure and each related, in logical sequence and proportion, to the rest of the range"
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Ary Shalizi @unsequenced.bsky.social · 10/09/2026
OMG, he has another lead compound, PAC-832. And it appears that the other 6/7ths of the original thread about PAC-3-3-10 are additional supporting data, like concentration of compound in the brain and open-field behavior tests.
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Ary Shalizi @unsequenced.bsky.social · 14/08/2026
YT served me this video, which has nearly 1M views. The audio is just the content creator reading a 24-year-old book review, word-for-word. The author of that review is still alive, and the content creator never asked for permission to use the text!
Screengrab of video thumbnail for YT creator MQTate’s video, “The Most Arrogant Science Book Ever Written.” The script for the video is a 2002 review of Wolfram’s “A New Kind of Science,” from the website bactra.org, used without the author’s permission.
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Ary Shalizi @unsequenced.bsky.social · 19/06/2026
I know I'm a nerd, but I'm not THAT kind of nerd! What's up with the ads I'm getting served these days?
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Ary Shalizi @unsequenced.bsky.social · 29/03/2026
Unfortunately, the Overton Window of this little free library shifted dramatically after I said "Oh dang, a complete Penguin Classics set of Kapital?!?!" 💙📚
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Ary Shalizi @unsequenced.bsky.social · 06/02/2026
In a double whammy, generative AI solves both nutrition and sustainability crises by discovering that people prefer homemade burgers to big macs AND that portobello or bean burgers can be delicious while having a smaller environmental footprint than beef? NO WAY.
A linkedin post from a Stanford AI researcher describing using generative AI to come up with "alternatives" to a big mac that discovers people prefer homemade hamburgers to mcdonalds hamburgers, and that portobello burgers and bean burgers can, in fact, be tasty an nutritious.
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Ary Shalizi @unsequenced.bsky.social · 05/02/2026
I get that the Superbowl is a high profile event, but having two Coast Guard speedboats with bow-mounted machine guns escort every Marin-SF commuter ferry seems like the definition of security theater?
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Ary Shalizi @unsequenced.bsky.social · 03/01/2026
Cannot possibly be accurate.
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Ary Shalizi @unsequenced.bsky.social · 28/12/2025
My father’s first visit to CA since the girls were born, showing his grandkids around the Berkeley campus. “I think those are the same tables they had when I was studying architecture.” “Yes, we ran down to that stream after Reagan ordered the soldiers to teargas the protestors.”
Older man with two girls looking through window to design studio where he studied six decades earlierMan shows stream on Berkeley campus to his granddaughter while reminiscing about his time as a student radical.
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Ary Shalizi @unsequenced.bsky.social · 22/12/2025
I feel like just the CAD files for . @cirquedusoleil.bsky.social must be incredible. The amount of technical effort necessary to pull off an effortless performance — breaking neither bones nor the illusion — is phenomenal. Kids should know that STEM skills are valuable for the arts, too.
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Ary Shalizi @unsequenced.bsky.social · 17/12/2025
Ok, so I finally got around to reading the copy of “If On a Winter’s Night a Traveler” a former colleague gave me 20 years ago, and how is “Electronic Production of Homogenized Literary Works” not part of the discourse around LLMs? #ai #booksky
Excerpt from chapter 6 of Italo Calvino’s novel “If On a Winter’s Night a Traveler”, describing the work of the Organization for the Electronic Production of Homogenized Literary Works (OEPHLW), which produces books using “computers… capable of completing [an unfinished manuscript] easily, programmed as they are to develop all the elements of a text with perfect fidelity to the stylistic and contextual models of the author.”
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Ary Shalizi @unsequenced.bsky.social · 05/12/2025
Hey, it's the silver anniversary of passing my quals! 3 cheers for off-topic learning about DNA repair that proved very career-relevant two decades later... And gratitude for committee member Phil Leder, who provided a nice afternoon tea to the other examiners, after changing the room last minute.
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Ary Shalizi @unsequenced.bsky.social · 05/12/2025
Wait, Forrest Gump is named after Nathan Bedford Forrest? I learned about NBF from Shelby Foote and Ken Burns...
Author Shelby Foote cuddles a pillow of his favorite Confederate general.
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Ary Shalizi @unsequenced.bsky.social · 04/12/2025
Ingrid Duner published some fresh research into Huxley and transhumanism, and found a note from Huxley pointing to a play by TS Eliot as his source for the term, replacing the “scientific humanism” and “evolutionary humanism” he had used for the same constellation of ideas since the 1920s.
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Ary Shalizi @unsequenced.bsky.social · 14/11/2025
“Jeffrey Epstein invited Deepak Chopra to lunch with George Church” is a sentence too wild to contemplate. Would they split one of those mammoth meatballs? (Chopra had other plans that day.) HOUSE_OVERSIGHT_029203.txt.pdf
Email says “george church and I having lunch at my institute at harvard sunday. Join?”
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Ary Shalizi @unsequenced.bsky.social · 08/11/2025
Text I received from a former labmate last night. Roughly sums up the vibe among molecular biologists I know.
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Ary Shalizi @unsequenced.bsky.social · 06/10/2025
What’s the connection between the Cuban revolution, the obesity epidemic, and GLP-1 agonists like Ozempic? The history of #biotechnology is wild! Currently reading Robert Bud’s fascinating “The Uses of Life,” and came across the following passage: 1/n
Passage from “The Uses of Life”, by Robert Bud. Key section states
“With high sugar prices in the United States during the early 1960s, [Japanese] work [on glucose metabolic enzymes] came to the notice of the Clinton Corn Processing Company, which in 1967 launched a complex enzyme system. It was commercially viable, but it was only in 1974 that Novo, and Gist Brocades in the Netherlands, developed cheap and effective methods. In the United States, this led to the widespread replacement of sunrise in the soft drinks industry. The 1975 glucose isomerase sales of $15m had increased to $40m by 1977 and $50m in 1980.”
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Ary Shalizi @unsequenced.bsky.social · 26/09/2025
Douglas Adams, The Hitchhiker’s Guide to the Galaxy. “Don’t panic!” (h/t Douglas Adams)
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Ary Shalizi @unsequenced.bsky.social · 26/09/2025
Isaac Asimov, I, Robot and Foundation “Logic is a wreath of pretty flowers that smells bad.” (h/t Spock)
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Ary Shalizi @unsequenced.bsky.social · 26/09/2025
J.R.R. Tolkien, The Silmarillion “Elves being a bunch of petty bitches to one another over a handful of sparkly rocks.”
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Ary Shalizi @unsequenced.bsky.social · 26/09/2025
Vernor Vinge, A Fire Upon the Deep “An extended fan-fiction treatment of the closing chapter of Timothy Ferriss’ Coming of Age in the Milky Way.”
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Ary Shalizi @unsequenced.bsky.social · 26/09/2025
Twofer: Dan Davies, The Unaccountability Machine David Runciman, The Handover “Modernity’s great trouble and advantage is that it works at scale.” (h/t Henry Farrell)
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Ary Shalizi @unsequenced.bsky.social · 26/09/2025
Ursula K. LeGuin, The Wind’s Twelve Quarters. “Though we cannot make our Sun Stand still, yet we will make him run.” (h/t Andrew Marvell)
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Ary Shalizi @unsequenced.bsky.social · 26/09/2025
Elinor Ostrom, Governing The Commons. “Every happy commons is alike, but every tragic commons is tragic in it’s own way.”
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Ary Shalizi @unsequenced.bsky.social · 29/08/2025
If you’d asked me on this day in 2005, “what will you be doing in 20 years?” “Filling out an online form to join a class action against an AI company that used my thesis publications without permission” would not have been on the bingo card. www.lieffcabraser.com/anthropic-au...
Flyer promoting doctoral thesis seminar with camera lucida drawing of Golgi stained cerebellar granule neurons.
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Ary Shalizi @unsequenced.bsky.social · 01/08/2025
Haldane wrote something quite similar. It’s a good quip, and I could absolutely picture him using it in conversation.
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Ary Shalizi @unsequenced.bsky.social · 01/08/2025
The New Empire of AI, in 1 sentence: “A hasty collage of other, better books.”
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Ary Shalizi @unsequenced.bsky.social · 01/08/2025
Doppegänger, in 1 sentence: “We contain troubling multitudes.”
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Ary Shalizi @unsequenced.bsky.social · 01/08/2025
Algorithms of Oppression, in 1 sentence: “Racism: there’s an app for that!” (Or possible “all apps are for that!”)
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Ary Shalizi @unsequenced.bsky.social · 01/08/2025
The Three-Body Problem, in 1 sentence: “I know that you know, that you know that I know that you know that humanity must be destroyed.”
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Ary Shalizi @unsequenced.bsky.social · 01/08/2025
Frankenstein, in 1 sentence: “It is a truth universally acknowledged, that a single monster, improperly made, must be in need of destroying its maker.”
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Ary Shalizi @unsequenced.bsky.social · 01/08/2025
Empire of AI, in 1 sentence: “Sometimes, it’s ok to hate the player and the game.”
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Ary Shalizi @unsequenced.bsky.social · 11/07/2025
Kara, Cobalt Red. “For the longest time I wouldn’t believe it, and then I saw the fields with my own eyes.”
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Ary Shalizi @unsequenced.bsky.social · 11/07/2025
Eubanks, Automating Inequality. Algorithms turn the safety net into a dragnet.
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Ary Shalizi @unsequenced.bsky.social · 11/07/2025
Bender & Hanna, The AI Con The book of the movie of the story of the musical of the podcast “Ridicule as Praxis.”
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Ary Shalizi @unsequenced.bsky.social · 11/07/2025
Fitzgerald, The Great Gatsby. The rich are different from you and me, they can afford looser morals.
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Ary Shalizi @unsequenced.bsky.social · 11/07/2025
Wynn-Williams, Careless People. “Look what they make you give.”
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Ary Shalizi @unsequenced.bsky.social · 11/07/2025
Atwood, The Year of the Flood and MaddAddam. Two books, one sentence: “God gave Noah the rainbow sign, no more water the fire next time.”
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Ary Shalizi @unsequenced.bsky.social · 11/07/2025
Quinn, How the World Made the West. “Luke, you’re going to find that many of the truths we cling to depend greatly on our own point of view.”
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Ary Shalizi @unsequenced.bsky.social · 16/05/2025
Had to complete my annual lab safety training yesterday, and the EH&S professional who made this example hazard label is evidently a Simpsons superfan. Brought a little joy to the day.
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Ary Shalizi @unsequenced.bsky.social · 30/04/2025
Cyclosporine/FK506/Rapamycin binding pocket on FKBP12. Not only how some of the most widely prescribed immunosuppressants work, but also the inspiration for chemically-induced proximity systems and molecular glues.
ribbon structure of cyclosporine bound to cyclophilin.
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Ary Shalizi @unsequenced.bsky.social · 23/04/2025
I like reading old books about biotechnology, because it’s interesting to see how the field talked about itself between major advances (totally inspired by @davekarpf.bsky.social’s “Future Now and Then” series). This passage is from a 1983 book, and company names are definitely less outré now…
Passage from J. Cherfas, “Man Made Life,” 1983. Describing the nascent international biotechnology industry in Europe, the Soviet Union, and India, he mentions an Italian company named “GenItalia.” Because back then, all company names seemed to be a portmanteau of prefix-gen (Biogen, Amgen) or gen-suffix (Genentech, Genzyme).
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Ary Shalizi @unsequenced.bsky.social · 11/04/2025
Since 1980, in fact. bsky.app/profile/unse...
NYT article from March 4, 1980, about Russian hopes to clone a mammoth using frozen tissue.
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Ary Shalizi @unsequenced.bsky.social · 11/04/2025
In addition to the Jungle, you might also consider Arrowsmith by Sinclair Lewis, to get an impression of medical care before antibiotics and widespread vaccination. #booksky
Cover of the novel Arrowsmith
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Ary Shalizi @unsequenced.bsky.social · 09/04/2025
The morphological species concept was good enough for Melville, so I guess it's good enough for me! Let's update those textbooks, chop! chop!
Text from Moby Dick → 

I submitted all this to my friends Simeon Macey and Charley Coffin, of Nantucket, both messmates of mine in a certain voyage, and they united in the opinion that the reasons set forth were altogether insufficient. Charley profanely hinted they were humbug.

Be it known that, waiving all argument, I take the good old fashioned ground that the whale is a fish, and call upon holy Jonah to back me. This fundamental thing settled, the next point is, in what internal respect does the whale differ from other fish. Above, Linnæus has given you those items. But in brief, they are these: lungs and warm blood; whereas, all other fish are lungless and cold blooded.
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Ary Shalizi @unsequenced.bsky.social · 21/03/2025
My academic work is good enough to steal!
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Ary Shalizi @unsequenced.bsky.social · 14/03/2025
May their names live in infamy.
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Ary Shalizi @unsequenced.bsky.social · 04/03/2025
And hope springs eternal! In October of 1999, hot on the heels of Dolly → "we are totally doing this mammoth thing, because it would be cool, and we owe the mammoths." Interesting how the public-facing rationale hasn't changed in at least a quarter of a century. 4/5
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Ary Shalizi @unsequenced.bsky.social · 04/03/2025
Five years later, in April of 1985 → "We should totally be able to do this, thanks to recombinant DNA." By this time, recombinant DNA was a standard lab tool, and Svante Paabo was getting started with ancient DNA. This article is lukewarm on de-extinction, but it does come up. 3/5
NYT article describing early work of Svante Paabo.
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