Ary Shalizi @unsequenced.bsky.social · 03/10/2026Today my 11yo fully grasped the concept of inflation. Visiting home to mark 1y since my mom passed, found my old LoTR paperbacks. Disgusted, she asks "why is the paper so... yellow?!" "Because these are 42 years old." "Ugh, so gross." "Yeah, look: 1984 edition, $3" "You could buy a book for $3?" 💙📚 060
Ary Shalizi @unsequenced.bsky.social · 24/09/2026Cell culture is hands on/brain off, and before podcasts I'd listen to the classes I didn't get to in undergrad. One UC course on the History of Information changed my ideas about information, and this 1965 thing about international paper sizes reminded me how physical an abstract concept can be. 110
Ary Shalizi @unsequenced.bsky.social · 10/09/2026OMG, he has another lead compound, PAC-832. And it appears that the other 6/7ths of the original thread about PAC-3-3-10 are additional supporting data, like concentration of compound in the brain and open-field behavior tests. 100
Ary Shalizi @unsequenced.bsky.social · 14/08/2026YT served me this video, which has nearly 1M views. The audio is just the content creator reading a 24-year-old book review, word-for-word. The author of that review is still alive, and the content creator never asked for permission to use the text! 000
Ary Shalizi @unsequenced.bsky.social · 19/06/2026I know I'm a nerd, but I'm not THAT kind of nerd! What's up with the ads I'm getting served these days? 010
Ary Shalizi @unsequenced.bsky.social · 29/03/2026Unfortunately, the Overton Window of this little free library shifted dramatically after I said "Oh dang, a complete Penguin Classics set of Kapital?!?!" 💙📚 040
Ary Shalizi @unsequenced.bsky.social · 06/02/2026In a double whammy, generative AI solves both nutrition and sustainability crises by discovering that people prefer homemade burgers to big macs AND that portobello or bean burgers can be delicious while having a smaller environmental footprint than beef? NO WAY. 010
Ary Shalizi @unsequenced.bsky.social · 05/02/2026I get that the Superbowl is a high profile event, but having two Coast Guard speedboats with bow-mounted machine guns escort every Marin-SF commuter ferry seems like the definition of security theater? 000
Ary Shalizi @unsequenced.bsky.social · 28/12/2025My father’s first visit to CA since the girls were born, showing his grandkids around the Berkeley campus. “I think those are the same tables they had when I was studying architecture.” “Yes, we ran down to that stream after Reagan ordered the soldiers to teargas the protestors.” 020
Ary Shalizi @unsequenced.bsky.social · 22/12/2025I feel like just the CAD files for . @cirquedusoleil.bsky.social must be incredible. The amount of technical effort necessary to pull off an effortless performance — breaking neither bones nor the illusion — is phenomenal. Kids should know that STEM skills are valuable for the arts, too. 000
Ary Shalizi @unsequenced.bsky.social · 17/12/2025Ok, so I finally got around to reading the copy of “If On a Winter’s Night a Traveler” a former colleague gave me 20 years ago, and how is “Electronic Production of Homogenized Literary Works” not part of the discourse around LLMs? #ai #booksky 130
Ary Shalizi @unsequenced.bsky.social · 05/12/2025Hey, it's the silver anniversary of passing my quals! 3 cheers for off-topic learning about DNA repair that proved very career-relevant two decades later... And gratitude for committee member Phil Leder, who provided a nice afternoon tea to the other examiners, after changing the room last minute. 100
Ary Shalizi @unsequenced.bsky.social · 05/12/2025Wait, Forrest Gump is named after Nathan Bedford Forrest? I learned about NBF from Shelby Foote and Ken Burns... 110
Ary Shalizi @unsequenced.bsky.social · 04/12/2025Ingrid Duner published some fresh research into Huxley and transhumanism, and found a note from Huxley pointing to a play by TS Eliot as his source for the term, replacing the “scientific humanism” and “evolutionary humanism” he had used for the same constellation of ideas since the 1920s. 110
Ary Shalizi @unsequenced.bsky.social · 14/11/2025“Jeffrey Epstein invited Deepak Chopra to lunch with George Church” is a sentence too wild to contemplate. Would they split one of those mammoth meatballs? (Chopra had other plans that day.) HOUSE_OVERSIGHT_029203.txt.pdf 000
Ary Shalizi @unsequenced.bsky.social · 08/11/2025Text I received from a former labmate last night. Roughly sums up the vibe among molecular biologists I know. 020
Ary Shalizi @unsequenced.bsky.social · 06/10/2025What’s the connection between the Cuban revolution, the obesity epidemic, and GLP-1 agonists like Ozempic? The history of #biotechnology is wild! Currently reading Robert Bud’s fascinating “The Uses of Life,” and came across the following passage: 1/n 110
Ary Shalizi @unsequenced.bsky.social · 26/09/2025Douglas Adams, The Hitchhiker’s Guide to the Galaxy. “Don’t panic!” (h/t Douglas Adams) 000
Ary Shalizi @unsequenced.bsky.social · 26/09/2025Isaac Asimov, I, Robot and Foundation “Logic is a wreath of pretty flowers that smells bad.” (h/t Spock) 100
Ary Shalizi @unsequenced.bsky.social · 26/09/2025J.R.R. Tolkien, The Silmarillion “Elves being a bunch of petty bitches to one another over a handful of sparkly rocks.” 100
Ary Shalizi @unsequenced.bsky.social · 26/09/2025Vernor Vinge, A Fire Upon the Deep “An extended fan-fiction treatment of the closing chapter of Timothy Ferriss’ Coming of Age in the Milky Way.” 100
Ary Shalizi @unsequenced.bsky.social · 26/09/2025Twofer: Dan Davies, The Unaccountability Machine David Runciman, The Handover “Modernity’s great trouble and advantage is that it works at scale.” (h/t Henry Farrell) 100
Ary Shalizi @unsequenced.bsky.social · 26/09/2025Ursula K. LeGuin, The Wind’s Twelve Quarters. “Though we cannot make our Sun Stand still, yet we will make him run.” (h/t Andrew Marvell) 100
Ary Shalizi @unsequenced.bsky.social · 26/09/2025Elinor Ostrom, Governing The Commons. “Every happy commons is alike, but every tragic commons is tragic in it’s own way.” 100
Ary Shalizi @unsequenced.bsky.social · 29/08/2025If you’d asked me on this day in 2005, “what will you be doing in 20 years?” “Filling out an online form to join a class action against an AI company that used my thesis publications without permission” would not have been on the bingo card. www.lieffcabraser.com/anthropic-au... 110
Ary Shalizi @unsequenced.bsky.social · 01/08/2025Haldane wrote something quite similar. It’s a good quip, and I could absolutely picture him using it in conversation. 110
Ary Shalizi @unsequenced.bsky.social · 01/08/2025The New Empire of AI, in 1 sentence: “A hasty collage of other, better books.” 000
Ary Shalizi @unsequenced.bsky.social · 01/08/2025Doppegänger, in 1 sentence: “We contain troubling multitudes.” 100
Ary Shalizi @unsequenced.bsky.social · 01/08/2025Algorithms of Oppression, in 1 sentence: “Racism: there’s an app for that!” (Or possible “all apps are for that!”) 100
Ary Shalizi @unsequenced.bsky.social · 01/08/2025The Three-Body Problem, in 1 sentence: “I know that you know, that you know that I know that you know that humanity must be destroyed.” 100
Ary Shalizi @unsequenced.bsky.social · 01/08/2025Frankenstein, in 1 sentence: “It is a truth universally acknowledged, that a single monster, improperly made, must be in need of destroying its maker.” 100
Ary Shalizi @unsequenced.bsky.social · 01/08/2025Empire of AI, in 1 sentence: “Sometimes, it’s ok to hate the player and the game.” 100
Ary Shalizi @unsequenced.bsky.social · 11/07/2025Kara, Cobalt Red. “For the longest time I wouldn’t believe it, and then I saw the fields with my own eyes.” 000
Ary Shalizi @unsequenced.bsky.social · 11/07/2025Eubanks, Automating Inequality. Algorithms turn the safety net into a dragnet. 100
Ary Shalizi @unsequenced.bsky.social · 11/07/2025Bender & Hanna, The AI Con The book of the movie of the story of the musical of the podcast “Ridicule as Praxis.” 100
Ary Shalizi @unsequenced.bsky.social · 11/07/2025Fitzgerald, The Great Gatsby. The rich are different from you and me, they can afford looser morals. 100
Ary Shalizi @unsequenced.bsky.social · 11/07/2025Wynn-Williams, Careless People. “Look what they make you give.” 100
Ary Shalizi @unsequenced.bsky.social · 11/07/2025Atwood, The Year of the Flood and MaddAddam. Two books, one sentence: “God gave Noah the rainbow sign, no more water the fire next time.” 111
Ary Shalizi @unsequenced.bsky.social · 11/07/2025Quinn, How the World Made the West. “Luke, you’re going to find that many of the truths we cling to depend greatly on our own point of view.” 100
Ary Shalizi @unsequenced.bsky.social · 16/05/2025Had to complete my annual lab safety training yesterday, and the EH&S professional who made this example hazard label is evidently a Simpsons superfan. Brought a little joy to the day. 000
Ary Shalizi @unsequenced.bsky.social · 30/04/2025Cyclosporine/FK506/Rapamycin binding pocket on FKBP12. Not only how some of the most widely prescribed immunosuppressants work, but also the inspiration for chemically-induced proximity systems and molecular glues. 040
Ary Shalizi @unsequenced.bsky.social · 23/04/2025I like reading old books about biotechnology, because it’s interesting to see how the field talked about itself between major advances (totally inspired by @davekarpf.bsky.social’s “Future Now and Then” series). This passage is from a 1983 book, and company names are definitely less outré now… 172
Ary Shalizi @unsequenced.bsky.social · 11/04/2025In addition to the Jungle, you might also consider Arrowsmith by Sinclair Lewis, to get an impression of medical care before antibiotics and widespread vaccination. #booksky 1100
Ary Shalizi @unsequenced.bsky.social · 09/04/2025The morphological species concept was good enough for Melville, so I guess it's good enough for me! Let's update those textbooks, chop! chop! 010
Ary Shalizi @unsequenced.bsky.social · 04/03/2025And hope springs eternal! In October of 1999, hot on the heels of Dolly → "we are totally doing this mammoth thing, because it would be cool, and we owe the mammoths." Interesting how the public-facing rationale hasn't changed in at least a quarter of a century. 4/5 110
Ary Shalizi @unsequenced.bsky.social · 04/03/2025Five years later, in April of 1985 → "We should totally be able to do this, thanks to recombinant DNA." By this time, recombinant DNA was a standard lab tool, and Svante Paabo was getting started with ancient DNA. This article is lukewarm on de-extinction, but it does come up. 3/5 100