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Ary Shalizi

@unsequenced.bsky.social
176 followers 190 following 778 posts

Biologist, book nerd, parent, hype skeptic in no particular order. Phenotypic screening for cell and chemical biology. Also, random book reviews at link. unsequenced.life

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Ary Shalizi @unsequenced.bsky.social · 25/09/2026
This time, I had so many open tabs — from 66 year old warnings about AI doom, to 20 years of claims that robots are about to do ALL the laboratory science — I gave them in their own entry. @chorye.bsky.social, if you want more of these for your automation classes, lmk!
unsequenced.life
One day, I’ll have time to read all of it?
Open tabs get their own post today. This approach to note taking might become a regular feature. It’s positively cathartic to close tabs this way.
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Ary Shalizi @unsequenced.bsky.social · 25/09/2026
Every change of season, I like to take stock of what's been happening in the world, what I've been reading, and make a list of tabs I'll get back to and read, I swear...
unsequenced.life
Books to read while the world burns: Sukkot 2026
Summer is always a mess. A mess of camps, with their shifting pick-up and drop-off times, of travel and lab and family commitments, and a collapsing republic. But books provide some welcome groundi…
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Ary Shalizi @unsequenced.bsky.social · 24/09/2026
Cell culture is hands on/brain off, and before podcasts I'd listen to the classes I didn't get to in undergrad. One UC course on the History of Information changed my ideas about information, and this 1965 thing about international paper sizes reminded me how physical an abstract concept can be.
Text on transition to international paper sizes in the UK, from a 1965 edition of Nature
THe proposed change-over to the metric system in Britain will necessarily take a long time for full realization and it will pose many practical problems, both industrial and domestic. Not the least of thoso is the effect on paper sizes and printing, where tradition is likely to die very hard. If the proposed scheme of the metric-based International Paper Sizes' is adoptod, it will completely revolutionize the present practice of the printing and publishing trades, with consequent repercussions in commerce, professional and private customs, particularly where books, pamphlets, display leaflets, stationery and envelopes are concerned, to mention only a few of the items involved. The keyword behind the conception of 'International Paper Sizes', as it is known, is simply rationalization. It means ... the introduction of a completely new range of paper sizes, from small to large, each based upon a metric measure and each related, in logical sequence and proportion, to the rest of the range"
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Ary Shalizi @unsequenced.bsky.social · 23/09/2026
2026 book thread, pt 22. Taking a break from the biology of aging with a suggestion iof my daughter's: Chelsea Sedoti's backwoods mystery, "Tell Me What Really Happened." #booksky #WritingCommunity
unsequenced.life
Ok, Zoomer?
Chelsea Sedoti’s Tell Me What Really Happened is a kinetic high school mystery that hits all the hot issues: Guns, race, class, social media… … and Sasquatch!
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Ary Shalizi @unsequenced.bsky.social · 22/09/2026
Bring back the triune brain. Make Sagan accurate again!
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Ary Shalizi @unsequenced.bsky.social · 18/09/2026
2026 book thread, pt 21. So, I read “Outlive” because it was relevant to my summer project of “popular books about aging.” For a book whose central message boils down to “better living through KPIs,” it was … better than I expected? #booksky #WritingCommunity
unsequenced.life
Death of the author
Longevity gurus are unavoidable, but Peter Attia and Bill Gifford’s Outlive was better than I expected. Leaving aside the author’s personal failings, it does a good job of explaining co…
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Ary Shalizi @unsequenced.bsky.social · 14/09/2026
“AI leaders identify face-saving excuse to dramatically reduce cash burn.”
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Ary Shalizi @unsequenced.bsky.social · 11/09/2026
2026 book thread, pt. 20. Margareta Magnusson's charming essay collections embrace the role of community and connection for healthy aging. Also, it helps to have an intact welfare state... #booksky
unsequenced.life
Swedish massage
Margareta Magnusson’s delightful diptych about growing old and letting go shows that healthy aging is all about attitude… if you’re lucky enough to do it in a robust welfare state.
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Ary Shalizi @unsequenced.bsky.social · 11/09/2026
Forgot to add #booksky when I posted last week. 2026 book thread, pt. 19. "Cracking the Aging Code" is a reminder that you don't need AI to produce slop. The central argument is that aging is adaptive and arose via group selection, but we should still try to stop it, because getting old is scary.
unsequenced.life
I have no need of that hypothesis
Have we got aging all wrong? Josh Mitteldorf and Dorion Sagan sure think so! Cracking the Aging Code is a book whose central argument boils down to “aging is good for the species and the plan…
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Ary Shalizi @unsequenced.bsky.social · 11/09/2026
After soccer practice today, the 8yo says out of nowhere: “Dad, I have an idea! Boba [long pause]… … Topped with cotton candy! I bet they have it in New York.”
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Ary Shalizi @unsequenced.bsky.social · 10/09/2026
I am so curious about the other 6/7ths of this thread. Does he share a structure? Is there some analytical chemistry to determine purity? What, exactly, does he mean by “improved”?
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Ary Shalizi @unsequenced.bsky.social · 04/09/2026
2026 book thread, pt. 19. "Cracking the Aging Code" is a good reminder that people can produce slop without AI. The central argument is that aging is adaptive and arose via group selection, but we should still try to stop it, because getting old is scary.
unsequenced.life
I have no need of that hypothesis
Have we got aging all wrong? Josh Mitteldorf and Dorion Sagan sure think so! Cracking the Aging Code is a book whose central argument boils down to “aging is good for the species and the plan…
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Ary Shalizi @unsequenced.bsky.social · 01/09/2026
Very disappointed in this episode. I listen exclusively to hear them dunk on Oberlin, and there was no dunking on Oberlin.
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Ary Shalizi @unsequenced.bsky.social · 14/08/2026
I work in drug discovery, and mine was after our daughters’ preschool closed in March 2020. My wife asked if the pandemic would really be done by summer like the news was saying. I said “no way, at least 500 days to develop and widely distribute anything effective enough.”
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Ary Shalizi @unsequenced.bsky.social · 14/08/2026
YT served me this video, which has nearly 1M views. The audio is just the content creator reading a 24-year-old book review, word-for-word. The author of that review is still alive, and the content creator never asked for permission to use the text!
Screengrab of video thumbnail for YT creator MQTate’s video, “The Most Arrogant Science Book Ever Written.” The script for the video is a 2002 review of Wolfram’s “A New Kind of Science,” from the website bactra.org, used without the author’s permission.
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Ary Shalizi @unsequenced.bsky.social · 13/08/2026
Laboratory automation does not make science easier. It makes it a different kind of difficult.
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Ary Shalizi @unsequenced.bsky.social · 11/08/2026
Hi, I'm looking for some basic advice on filing a #FOIA request. The NIH used to post their Wednesday Afternoon Lecture Series on a public website, with lectures dating back to the late 1990s. I've been planning a research project on how scientific presenting styles have changed, . : 1/n
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Ary Shalizi @unsequenced.bsky.social · 07/08/2026
2026 book thread, pt. 18. An ambitious but flawed polemic about how Americans approach health and aging and so much more. Barbara Ehrenreich’s “Natural Causes.” #booksky
unsequenced.life
Ok, boomer
Book six of Critical Aging Summer is a cranky polemic about how attempting to do anything for your health is pretty much pointless, because you’ll die no matter what you do. Barbara Ehrenreic…
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Ary Shalizi @unsequenced.bsky.social · 01/08/2026
My Italian mom used to say “inshallah” all the time. She was an atheist who married a non-practicing muslim and just preferred it as an alternative to “let’s hope so.”
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Ary Shalizi @unsequenced.bsky.social · 17/07/2026
This joke is historically inaccurate…
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Ary Shalizi @unsequenced.bsky.social · 17/07/2026
2026 book thread, pt. 17 An actually interesting, well written book about aging, and how different it looks across phyla: Steven Austad's "Methuselah's Zoo." 🧪 #booksky
unsequenced.life
Achieving organism
Steven Austad’s delightful Methuselah’s Zoo is worth reading even if you don’t care about aging or longevity. It’s an engrossing work of natural history, detailing the very …
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Ary Shalizi @unsequenced.bsky.social · 10/07/2026
2026 book thread, pt. 16 The summer of aging books continues. Next up: Eric Topol’s ”Super Agers,” which is very well sourced. 🧪 #booksky unsequenced.life/2026/07/10/s...
unsequenced.life
You can’t spell “aging” without “AI,” amirite?
Super Agers, by Eric Topol (2025, Simon and Schuster, 464p.) In 1 sentence: Worth it for the footnotes. Super Agers left me ambivalent. It’s quite different from the first three books I read for Cr…
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Ary Shalizi @unsequenced.bsky.social · 09/07/2026
Before kids, the neighborhood running store was the center of my social life, because they sponsored saturday trail runs and thursday fun runs with a happy hour after…
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Ary Shalizi @unsequenced.bsky.social · 07/07/2026
Matilda the Musical, but Ms. Honey's parents are eschatologists...
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Ary Shalizi @unsequenced.bsky.social · 04/07/2026
I just told my older daughter that a word was “cromulent,” and she understood the meaning from context immediately. But she has no idea of the word‘s origin, and I’m not sure if I should tell her…
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Ary Shalizi @unsequenced.bsky.social · 03/07/2026
2026 book thread, pt. 15 A bit longtermist/EA coded, but a well-written survey of aging biology nonetheless. Ageless (2020), by Andrew Steele. #booksky
unsequenced.life
Possible, plausible, practical, preferable?
Ageless, by Andrew Steele, stumbles a bit out of the gate, but is ultimately a charming exploration of the biology of aging and possible routes to intervention. Worth a read.
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Ary Shalizi @unsequenced.bsky.social · 26/06/2026
2026 book thread, pt. Some books about aging are really, really bad! For example, “The Science and Technology of Growing Young,” which is too on the nose for satire. Read @adambecker.bsky.social instead! 💙📚
unsequenced.life
Resistance is futile
There’s optimism about where science can take us, and then there’s Sergey Young’s The Science and Technology of Growing Young: An Insider’s Guide to the Breakthroughs that W…
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Ary Shalizi @unsequenced.bsky.social · 19/06/2026
I know I'm a nerd, but I'm not THAT kind of nerd! What's up with the ads I'm getting served these days?
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Ary Shalizi @unsequenced.bsky.social · 12/06/2026
2026 book thread, pt 13. A fascinating collection of key papers in biology I found on my mom's bookshelf, "Modern Biology: It's Conceptual Foundations." By Elof Carlson, published in 1967. 💙📚 #histstm
unsequenced.life
Those were the good old days…
Modern Biology: Its Conceptual Foundations, a 1967 compendium of thirty landmark papers from the 17th-20th century, shows how the central ideas of biology have been remarkably stable for more than …
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Ary Shalizi @unsequenced.bsky.social · 05/06/2026
2026 book thread, pt 12. Since I nominally work on aging biology, thought I'd spend the summer doing a deep dive on books about aging and lifespan extension. First up: Why We Die, by Venki Ramakrishnan. Actually, quite good, probably because he is not a True Believer. 💙📚
unsequenced.life
Why we live
The first book of Critical Aging Summer is probably the best, Why We Die, by Nobel laureate Venki Ramakrishnan. An accessible introduction to the biology of aging, with a thoughtful discussion of t…
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Ary Shalizi @unsequenced.bsky.social · 28/05/2026
It will take decades to recover from this. Whenever I hear @edzitron.com talk about AI capex, I convert it into "how many NIH annual budgets is that?" If the $800bn+ estimated spend in 2026 is accurate, that's a quarter century of NIH research. All the grants. All the scientists. 1/n
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Ary Shalizi @unsequenced.bsky.social · 23/05/2026
Whoops! I wish it was 2010, but that was actually pt. 10. of my 2026 book thread. Anyway, here is pt. 11. Book club with one of my daughters, The Fellowship of the Ring by JRR Tolkien. 💙📚
unsequenced.life
The Fellowship of the MacGuffin
Reading Tolkien to my daughter, or The Best Book Club Goes Back to Middle Earth.
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Ary Shalizi @unsequenced.bsky.social · 17/05/2026
Also, why people should stop quoting that one line from Jurassic Park about "not stopping to think if they should..." Since well before recombinant DNA, there have been attempts to justify messing with biology in quite substantial ways.
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Ary Shalizi @unsequenced.bsky.social · 16/05/2026
2010 book thread, pt. 10. Even a bad book can take you interesting places. I really disliked this one about synthetic biology. But it is an interesting starting point for a deep dive on the ideology of synthetic biology, and a certain kind pop science book. Higher Animals, by Michael Specter 💙📚
unsequenced.life
Hopemaxxing, Hypemaxxing, Fearmaxxing
Did you know that synthetic biology is going to save the world?Or possibly destroy it?Maybe both!Or neither, you know, whatever. It depends. But it’s going to change everything, and you bette…
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Reposted by Ary Shalizi
Henry Farrell @himself.bsky.social · 11/05/2026
knightcolumbia.org/content/ai-a... Now up at @knightcolumbia.org - Cosma Shalizi and myself on "AI as Social Technology." It says that AI models are really a technology of social mediation that allow humans to connect with thoughts of other humans. Short-ish thread with major points follows.
knightcolumbia.org
AI as Social Technology
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Ary Shalizi @unsequenced.bsky.social · 11/05/2026
2026 book thread, pt. 9. A charming book about cephalopod cognition, which proved a nice palate cleanser after Blindsight. Other Minds, by Peter Godfrey-Smith. 💙📚
unsequenced.life
Eight arms and nine minds
Okay, the obvious tease here would be to quote from “Octopus’s Garden.” I won’t do that. But here’s a fun book about cephalopod behavior.Other Minds, by Peter Godfrey-…
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Ary Shalizi @unsequenced.bsky.social · 02/05/2026
Femininecronomicon.
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Ary Shalizi @unsequenced.bsky.social · 01/05/2026
My fat thumbs accidentally typed "Cthappell Roan," and now I can't stop gibbering about the eldritch horrors of the Pink Shoggoth Club...
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Ary Shalizi @unsequenced.bsky.social · 01/05/2026
2026 book thread, pt. 8. The appeal of so-called "hard sci-fi" still eludes me. Blindsight, by Peter Watts. 💙📚
unsequenced.life
Stochastic parrots in spaaace!
Hard sci-fi full of big ideas and unpleasant people. Pew! Pew!
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Ary Shalizi @unsequenced.bsky.social · 24/04/2026
2026 book thread, pt. 7. The very recognizable world of 100 years ago in New York. Manhattan Transfer, by John Dos Passos. 💙📚
unsequenced.life
Same as it ever was
Have you seen New York? Well, the book is better. John Dos Passos introduces us to the people and problems of New York City in the present day, a century ago.
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Ary Shalizi @unsequenced.bsky.social · 17/04/2026
Whoever said an army marches on its stomach didn't know warfighting like Hegseth.
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Ary Shalizi @unsequenced.bsky.social · 13/04/2026
2026 book thread, pt. 6. Better living through biology... 💙📚
unsequenced.life
At once marginal and central
In The Age of Living Machines, Susan Hockfield provides an optimistic introduction to the many ways biology could upend multiple industries. The science is explained clearly, and the use cases are …
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Ary Shalizi @unsequenced.bsky.social · 29/03/2026
So, not a book, but I would say the Jason Bourne movies reinvented the spy genre. Just look at how the 007 franchise pivoted in response!
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Ary Shalizi @unsequenced.bsky.social · 29/03/2026
Unfortunately, the Overton Window of this little free library shifted dramatically after I said "Oh dang, a complete Penguin Classics set of Kapital?!?!" 💙📚
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Ary Shalizi @unsequenced.bsky.social · 20/03/2026
So I'm reading LoTR to my 8yo, and I needed to do different voices so she could keep the characters straight. But I only know two British accents (Michael Caine as upper class confidant, or Michael Caine as lower class scoundrel), so I had to come up with some other ones. As a result, she will now
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Ary Shalizi @unsequenced.bsky.social · 17/03/2026
2026 book thread, pt. 5. Two versions of the same story, told 150 years apart... 💙📚
unsequenced.life
Theme and Variations
The journey of Huck and James, as imagined by Samuel and Percival.
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Ary Shalizi @unsequenced.bsky.social · 09/03/2026
2026 book thread, pt. 4. Aldous Huxley's last novel was definitely less fun than reading The Hobbit to my 8yo. 💙📚
unsequenced.life
Fantasy Island
Aldous Huxley’s final novel offers readers the utopian alternative to Brave New World they never asked for: His brother Julian’s Transhumanism.
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Ary Shalizi @unsequenced.bsky.social · 06/03/2026
Reposting because the heart is not an appropriate response.
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Ary Shalizi @unsequenced.bsky.social · 20/02/2026
2026 book thread, pt. 3. Reading The Hobbit with my daughters. 💙📚
unsequenced.life
Back there again, and…
Introducing the world’s best book club to the wonders of Middle Earth…
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Ary Shalizi @unsequenced.bsky.social · 06/02/2026
In a double whammy, generative AI solves both nutrition and sustainability crises by discovering that people prefer homemade burgers to big macs AND that portobello or bean burgers can be delicious while having a smaller environmental footprint than beef? NO WAY.
A linkedin post from a Stanford AI researcher describing using generative AI to come up with "alternatives" to a big mac that discovers people prefer homemade hamburgers to mcdonalds hamburgers, and that portobello burgers and bean burgers can, in fact, be tasty an nutritious.
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