Reposted by UMN Medicinal Chemistry
Take a look at recent work from Jared J. Anderson and @danharki.bsky.social on the identification of a novel allosteric binding site on the catalytic domain of NF-κB inducing kinase (NIK)🔥⬇
pubs.rsc.org/en/content/a...
📍 @umnmedchem.bsky.social
#chemsky🧪
pubs.rsc.org
Identification of a novel allosteric binding site on the catalytic domain of NF-κB inducing kinase (NIK)
NF-κB inducing kinase (NIK) is the central regulatory component of noncanonical NF-κB signalling and has been implicated in a variety of cancers and immune disorders. While NIK has been pursued as a…