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Reposted by Sara Marie Ulv Larsen

PLOS Biology @plosbiology.org · 25/11/2025

Sleep supports brain health partly by regulating fluid dynamics to clear waste. @ulvlarsen.bsky.social &co probe the relation between #sleep & fluid movement in the human #brain, finding that #SleepPressure & intensity have distinct effects on brain pulsations @plosbiology.org 🧪 plos.io/3XQWCL6

Sleep pressure and slow-wave-rich NREM sleep exert distinct effects on cerebral vasomotion and on brain pulsations driven by respiratory and cardiac forces. Heightened sleep pressure (following 35 h of wakefulness) promotes vasomotion (yellow box). Slow-wave-rich NREM sleep enhances brain pulsations driven by the respiratory and cardiac cycles—more so in gray and white matter than in the ventricles (red boxes). The respiration- and cardiac-driven brain pulsations also intensify with deeper sleep (N3 > N2) and correlate with EEG delta power, which is a measure of slow-wave activity (light vs. dark red boxes).

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Reposted by Sara Marie Ulv Larsen

PLOS Biology @plosbiology.org · 25/11/2025

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Reposted by Sara Marie Ulv Larsen

Eric Topol @erictopol.bsky.social · 09/01/2025

How the brain gets rid of its chemical waste through the glymphatics during sleep, via blood vessel oscillations, regulated by norepinephrine. Impeded by Ambien! www.cell.com/cell/abstrac... www.science.org/content/arti...

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Reposted by Sara Marie Ulv Larsen

Søren Grubb @sorengrubb.bsky.social · 10/06/2025

🐭🧠 #PrecapillarySphincters (PS) at the #arteriole–#capillary junction rapidly dilate ~30% in seconds during #SensoryStimulation—regulating #capillary #BloodFlow dynamically. Here we investigated whether they protect downstream microvessels during abrupt #BloodPressure surges 🧪🧵

Showing how a precapillary sphincter dilates during high blood pressure

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Reposted by Sara Marie Ulv Larsen

Ian Harrison @ianharrisonneuro.bsky.social · 16/11/2024

Our latest preprint out on bioRxiv...we show that glymphatic function influences synuclein propagation in the brain 🧠

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Reposted by Sara Marie Ulv Larsen

Jonathan Kipnis @jonykipnis.bsky.social · 04/05/2025

Excited having this review with Mitch Kim on glymphatic, brain clearance, and neuroimmunology published.

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