Summary: A Review of evidence suggesting that aging arises from progressive loss of mechanotransduction fidelity across the extracellular matrix (ECM)–cytoskeleton–nucleus axis, linking ECM remodeling...

Detailed analyses of ligand choice, linkage vector and linker length enabled the development of bitopic inhibitors of ABL1 and EGFR kinases, including an ABL1 inhibitor with enhanced activity aga...

Cavanaugh et al. show that embryos from aged mice have increased contractility and tissue viscosity on embryonic day 4.5, which leads to poor spreading and attachment. Similar age-associated mechanica...

We currently lack scalable approaches to systematically reveal the genetic underpinnings of neuronal function in health and disease. Here, the authors develop a platform to uncover genes affecting neu...

Ischemic injury to the somatosensory ventrobasal (VB) thalamus is strongly associated with central post-stroke pain (CPSP), yet preclinical models of …

In human rotator cuff surgical samples, a DLK1+ subset of fibroadipogenic progenitor cells is identified that can limit fatty infiltration in mice.

Neurodegenerative diseases, such as Parkinson's disease (PD) and Alzheimer's disease (AD), globally pose a significant challenge with an aging populat…

McQuade et al. identified transcriptional regulators for six microglial activation states associated with brain disorders. They deeply characterized complex, multi-state regulators and identified comm...

The essential question in evaluating lung transplant candidates is whether that individual will benefit from transplantation. While lung transplantation is associated with improvements in physical fun...

Mafb and c-Maf transcription factors (TFs) are expressed in medial ganglionic eminence (MGE) lineages, beginning in progenitors and continuing into mature GABAergic parvalbumin-positive (PV+) and soma...

FBXO42 is a poorly characterized F-box protein essential in 15% of cancer cell lines from diverse lineages. High-throughput approaches indicate that FBXO42 function correlates with that of coiled-coil...

Abstract. Benzoxaboroles offer unusual reactivity and protein recognition for the development of small molecule drugs. Despite this potential, they are unc

The HTRA2–CLPB proteostasis system is a mitochondrial quality control module whose dysfunction drives local oxygen toxicity, which can be mitigated by lowering ambient oxygen levels.

AbstractBackground and Objectives. This systematic review aimed to synthesize risk and protective factors associated with depressive symptoms in older adul