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Bakar Aging Research Institute @ucsfaging.bsky.social · 16/10/2026

febs.onlinelibrary.wiley.com/doi/epdf/10....

Bakar Aging Research Institute @ucsfaging.bsky.social · 14/10/2026

BARI’s Daniel Mordes and Julie Smeyers unpack how low TBK1 raises risk for ALS and related dementias. Cells can’t clear junk as well, and the brain’s immune cells get out of balance. Helpful look at a dual problem. #ALS #dementia www.frontiersin.org/journals/neu...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 02/10/2026

BARI’s Dr. Kevan Shokat and colleagues in Nature: a design playbook for bitopic kinase inhibitors. Two grips on one kinase. Their ABL1 lead, PonatiLink-2, stays potent against resistance mutations and could be given at higher doses in mice without the toxicity seen with ponatinib.

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Bakar Aging Research Institute @ucsfaging.bsky.social · 01/10/2026

BARI spotlight: Margaret Wallhagen co-authors a Nursing Outlook piece on why geroscience is richer with nurses as the table. Trusted messengers. Holistic care. A life-course view of aging. #nursing #geroscience www.nursingoutlook.org/article/S002...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 29/09/2026

Scott Bauer and colleagues show that older adults report more urinary symptoms when slow walking takes a bigger part of their energy capacity, pointing to a possible shared pathway with mobility decline. link.springer.com/article/10.1... #aging #geriatrics

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Bakar Aging Research Institute @ucsfaging.bsky.social · 24/09/2026

New protocol from BARI’s Andrew Yang: isolate cerebral vessels, then pull high-purity nuclei for multi-omics. Blood-brain barrier cells are usually undercounted, this gives labs a clearer look at them. #neuroscience www.nature.com/articles/s41...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 23/09/2026

This week is Postdoc Appreciation Week and we’re grateful for the BARI postdocs who keep our science moving! You bring the experiments, the ideas, the late nights, and the questions that push aging biology forward. Thank you for being such a vital part of this community!

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Bakar Aging Research Institute @ucsfaging.bsky.social · 22/09/2026

BARI spotlight: Kevan Shokat maps adaptive cell-cycle control in cancer and the emerging toolkit for CDK2 targeting. Useful reading for anyone thinking about kinase drugs after CDK4/6. #cancer www.nature.com/articles/s41...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 18/09/2026

BARI’s Isha Jain maps the surprising diversity of terminal electron acceptors across eukaryotes. Oxygen isn’t the only destination, and those anaerobic backups still matter in low-oxygen tissues and disease. www.cell.com/action/showP...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 16/09/2026

BARI spotlight: Martin Kampmann’s group used genome-wide CRISPRi to find regulators of the interferon-responsive microglial state. Known interferon genes plus unexpected hits. A toolkit for asking when this program helps or harms the aging brain. #Microglia #aging bit.ly/4reK3az

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Bakar Aging Research Institute @ucsfaging.bsky.social · 15/09/2026

BARI’s Katrina Abuabara & team find higher estimated salt intake is associated with more IL-17-related inflammatory disease in ~470,000 UK Biobank participants, especially skin and joint conditions. Worth asking whether cutting salt could help. www.clinicalnutritionespen.com/article/S240...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 10/09/2026

Cool story from one of BARI’s newest members, Jason Gestwicki. Tau fibrils formed without cofactors are dynamic, and evolve over weeks unless agitation or polyanions stabilize them. A fresh look at how disease-specific tau folds may mature. pmc.ncbi.nlm.nih.gov/articles/PMC...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 09/09/2026

Congrats to BARI’s Orion Weiner & team for their recent work in Nature Cell Biology identifying a mechanical cause of age-related implantation failure: embryos from older females are overly contractile, hindering their ability to implant.

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Bakar Aging Research Institute @ucsfaging.bsky.social · 08/09/2026

BARI spotlight: Martin Kampmann’s & team present a new CRISPR screen for genes that change how neurons depolarize. In human iPSC-derived neurons, they found known excitability players and disease genes not previously tied to firing. Excellent resource for the field. #Neuroscience #CRISPR

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Bakar Aging Research Institute @ucsfaging.bsky.social · 01/09/2026

New BARI member Marina Sirota and colleagues used computational drug repurposing to identify simvastatin and primaquine as candidates for endometriosis. Both eased pain behaviors in rats, simvastatin was also linked to lower disease risk in patient records. www.cell.com/action/showP...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 31/08/2026

New BARI member Reza Abbasi-Asl & colleagues find that daily step patterns, especially mid-day activity, reflect disability in progressive MS and can complement traditional clinic tests. Great use of wearable data! #MSResearch #wearables journals.sagepub.com/doi/10.1177/...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 26/08/2026

BARI’s community just got stronger. Please join us in welcoming our newest members. Their work ranges from how the brain and immune system change with age to the molecular and computational tools that will help us understand those changes. Meet the new members: geroscience.ucsf.edu/news/new-mem...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 26/08/2026

Proud moment for BARI: Greg Bieri from the Villeda lab has been named a 2026 Simons Fellows-to-Faculty Awardee. This highly competitive program provides support to help outstanding postdocs transition to faculty positions.

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Bakar Aging Research Institute @ucsfaging.bsky.social · 18/08/2026

Job alert from BARI! Seeking a passionate, highly motivated person to lead community building across our aging biology network. If you love connecting people and advancing the science of aging, this could be your role! Know someone perfect? Share or apply here: careers.ucsf.edu/careers/JobD...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 18/08/2026

Congrats to BARI’s Brian Feeley on this Science Translational Medicine paper! His group mapped human fibroadipogenic progenitors in rotator cuff muscle and found that a DLK1+ subset acts as a natural brake on fatty infiltration. Beautiful work with real clinical relevance. #muscleinjury #orthopedics

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Bakar Aging Research Institute @ucsfaging.bsky.social · 12/08/2026

New review! BARI’s Su Guo discusses how intranasal delivery offers a promising route to get therapies into the brain for Alzheimer's and Parkinson’s, but significant hurdles remain. Excellent overview of platforms, models, and computational tools. #Alzheimers #Parkinsons

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Bakar Aging Research Institute @ucsfaging.bsky.social · 11/08/2026

Huge congrats to BARI’s Martin Kampmann on this landmark Neuron paper! His team mapped the transcriptional regulators of six microglial activation states linked to brain disease and showed how knocking down specific factors can drive disease-associated programs. A real toolkit for the field!

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Bakar Aging Research Institute @ucsfaging.bsky.social · 07/08/2026

Big congrats to BARI’s John Greenland on this thoughtful ERJ Open Research editorial! Frailty improves for most lung transplant patients, especially those who start most frail, yet understanding which cases are driven by biology versus deconditioning could sharpen candidate selection and care.

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Bakar Aging Research Institute @ucsfaging.bsky.social · 05/08/2026

New from BARIs Jeroen Roose: Rasgrp1 fine-tunes EGFR signals so the mammary gland can elongate and branch properly during puberty. Lose that control and terminal end buds linger while proliferation runs high. A lovely example of signaling balance in organ development. #developmentalbiology

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Bakar Aging Research Institute @ucsfaging.bsky.social · 04/08/2026

BARI spotlight: Dengke Ma and team reveal that rhythmic proton/ionic stress in the intestine coincides with (and can drive) developmental sleep in C. elegans. Their new GENTIS sensor makes these dynamics visible in real time. #neuroscience #sleepscience www.science.org/doi/epdf/10....

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Bakar Aging Research Institute @ucsfaging.bsky.social · 30/07/2026

BARI spotlight: Aric Prather & team find that racial differences in non-REM sleep (especially reduced deep-sleep delta power) contribute to memory differences overnight. Sleep may be a critical pathway for supporting cognitive resilience! www.ovid.com/jnls/bsam/fu...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 21/07/2026

How does a tiny zebrafish rebuild its tail after injury? One key player is a carefully timed shift in intracellular pH. New work from BARI’s Diane Barber shows that after tail amputation, cells first drop then raise their internal pH.

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Bakar Aging Research Institute @ucsfaging.bsky.social · 15/07/2026

(like walking & standing up) beyond what we see from muscle size or density alone. Such a promising step toward understanding healthy aging! #muscleaging #healthyaging academic.oup.com/biomedgeront...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 14/07/2026

Ever wonder how a fish that lives just a few months could unlock secrets of aging and suspended animation? BARI’s Param Priya Singh just launched Killiverse: an interactive platform that brings together multi-omics data from killifish species like the African turquoise killifish.

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Bakar Aging Research Institute @ucsfaging.bsky.social · 09/07/2026

Congrats to BARI’s Margaret Wallhagen on this thoughtful new review in The Gerontologist! Her team looked at what raises or lowers depression risk in older adults with vision loss and found that social support and good coping skills really help. Useful insights for supporting healthy aging!

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Bakar Aging Research Institute @ucsfaging.bsky.social · 08/07/2026

Big congratulations to BARI’s Suneil Koliwad on this important JCI Insight paper! People with HIV show a distinct form of scarring in their body fat that drives insulin resistance and higher diabetes risk, even in those who are not obese. Real progress toward protecting metabolic health in HIV!

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Bakar Aging Research Institute @ucsfaging.bsky.social · 07/07/2026

BARI spotlight: John Greenland’s new review beautifully links the origins of rapamycin on Easter Island to today’s innovative nanoparticle approaches for lung transplantation.

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Bakar Aging Research Institute @ucsfaging.bsky.social · 06/07/2026

Huge congratulations to BARI’s Roarke Kamber on being selected as a 2026 Pew-Stewart Scholar for Cancer Research! His lab is digging into how macrophages and cancer cells interact, work that could lead to smarter ways to fight tumors! #PewScholars #CancerResearch geroscience.ucsf.edu/news/pioneer...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 01/07/2026

Huge congrats to BARI’s Orion Weiner on this stunning Nature Cell Biology paper! Migrating cells don’t just have a front and back, they actively help each other across the whole cell.

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Bakar Aging Research Institute @ucsfaging.bsky.social · 30/06/2026

BARI spotlight: Alexis Combes and team turned routine biopsy samples into rich maps of what’s happening in inflamed guts. Their work highlights cellular patterns linked to treatment success, offering new paths to help patients with ulcerative colitis get the right therapy sooner. #GutHealth #IBD

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Bakar Aging Research Institute @ucsfaging.bsky.social · 25/06/2026

Big cheers for BARI’s Paul Wolter’s on this breakthrough! Telomere-stressed AT2 cells turn profibrotic early in lung fibrosis, p53 is the driver. Inhibiting it reverses damage, boosts healthy AT2 cells & halts fibrosis. Hopeful step toward better IPF therapies! academic.oup.com/ajrccm/artic...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 25/06/2026

Proud to highlight Christopher Hernandez’s review urging the field to target bone matrix quality for better fragility fracture prevention. Matrix mechanical properties matter as much as density, and they’re modifiable. A compelling case for new therapeutic strategies beyond current approaches.

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Bakar Aging Research Institute @ucsfaging.bsky.social · 23/06/2026

BARI spotlight: Dena Dubal urges a shift in how we approach Alzheimer’s, recognizing women’s unique mix of vulnerability and resilience. Strong call for more research on female biology, sex-tailored care, and discoveries that help everyone age better. Important perspective! #Alzheimers #Womenshealth

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Bakar Aging Research Institute @ucsfaging.bsky.social · 18/06/2026

Check this out from BARI’s Kevan Shokat: Chai-1 deep learning makes crystal-quality models of covalent K-Ras complexes fast, accurate, and works great with covalent restraints for tough targets. Super useful for speeding up drug discovery! #Kras #drugdiscovery

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Bakar Aging Research Institute @ucsfaging.bsky.social · 17/06/2026

Big cheers for BARI’s Sarah Knox on this new iScience paper! Simple PBS rewetting restores damaged corneal stroma in autoimmune dry eye, fixing collagen, basement membrane & shifting keratocytes to reparative mode. Game-changer for dry eye! #opthalmology #dryeye www.cell.com/action/showP...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 16/06/2026

Big cheers for BARI’s Jayanta Debnath on this new Autophagy review! Membrane ATG8ylation helps cells secrete proteins, load EVs, and handle everything from metabolism to immune responses via clever non-degradative autophagy routes. Super interesting deep dive! pubmed.ncbi.nlm.nih.gov/42178909/

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Bakar Aging Research Institute @ucsfaging.bsky.social · 11/06/2026

BARI’s celebrating Dengke Ma’s latest in Cell Reports! They uncovered how the ER guards itself against H2O2 with ERGU-1/TMEM161B, keeping protein folding smooth and supporting reproduction & stress responses. Outstanding discovery! pubmed.ncbi.nlm.nih.gov/42241275/

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Bakar Aging Research Institute @ucsfaging.bsky.social · 05/06/2026

BARI is celebrating Andrew Yang’s Cell study! They developed genetic tracing to show brain protein clearance is regionally organized, with specialized border niches. Neuroinflammation and amyloid disrupt it differently, key for understanding neurodegeneration. Beautiful work!

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Bakar Aging Research Institute @ucsfaging.bsky.social · 03/06/2026

Big cheers for BARI’s Katrina Abuabara on her new JAAD review! Atopic dermatitis is still diagnosed the old-fashioned way, history + exam + established criteria, but standardized tools make assessment clearer and care more consistent. Super practical guidance for clinicians!

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Bakar Aging Research Institute @ucsfaging.bsky.social · 26/05/2026

BARI is celebrating Kevan Shokat’s new ACS Chem Biol study! They designed long-acting CFTR potentiators by tweaking the protein-membrane interface, longer lipophilic chains dramatically extend activity via enhanced membrane retention. Exciting for CF and membrane drug design!

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Bakar Aging Research Institute @ucsfaging.bsky.social · 21/05/2026

BARI is celebrating Dr. Dean Sheppard’s latest in Thorax! It shows circulating CTHRC1 is elevated in IPF patients and strongly linked to disease severity and survival, a clear reflection of the pathological fibroblasts driving fibrosis. Important step forward for better patient care.

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Bakar Aging Research Institute @ucsfaging.bsky.social · 20/05/2026

Big cheers for BARI’s Michelle Arkin on her new PNAS paper! Molecular glues fix a key regulatory interaction in Noonan syndrome, restoring balance to MAPK signaling. This has real potential for targeted therapies for RASopathies! www.pnas.org/doi/10.1073/...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 19/05/2026

BARI is celebrating our Director Leanne Jones, freshly inducted into the Academy of Geroscience! Her pioneering work in stem cells and tissue maintenance keeps pushing the frontiers of healthy aging research. What an honor for our leader and for BARI! www.prnewswire.com/news-release...

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Bakar Aging Research Institute @ucsfaging.bsky.social · 13/05/2026

Nice work from BARI’s Martin Kampmann: In lab-grown neurons with an FTD-linked tau mutation, both the mutation and reducing tau led to shorter axons and changes in axon-related pathways.

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Bakar Aging Research Institute @ucsfaging.bsky.social · 11/05/2026

Congrats to BARI’s Dena Dubal: Klotho isn’t just a longevity factor, it protects cognition in Parkinson’s. Human data + mouse models show it rescues synaptic plasticity and lowers α-syn toxicity. Fantastic work! www.jneurosci.org/content/jneu...

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