The E3-ome defines the human repertoire of ubiquitin E3 ligases, creating a unified resource that maps their diversity across the ubiquitin and ubiquitin-like systems. By consolidating fragmented know...

Caspase-2 is a key genome-surveillance protease that functions to kill or arrest cells with abnormal chromosome content, via PIDDosome-dependent and -independent mechanisms. However, this surveillance...

Identification of new regulators of Arabidopsis IRT1 endocytosis and metal transport using TurboID. TurboID proximity labeling of the Arabidopsis IRT1 root metal transporter identified new IRT1-inter....

The approval of the first Protac cancer drug marks a turning point in medicine - but scientists are only beginning to decode the complex molecular language that makes it possible

Recent studies have expanded the field of autophagy in immunity to include related but incompletely understood noncanonical autophagy processes. Deretic reviews these advancements in the context of im...

Autophagy-related proteins are increasingly recognized for functions beyond canonical autophagosome-mediated degradation. Our recent work identifies ATG9A-positive vesicles as a dedicated, autophagy-i...