iiinova — where your digital self keeps evolving

Strange, that AI search apparently missed this chart:

Joe @twitskeptic.sirvin.com · 01/10/2026

And I hadn't heard about dedifferentiation in this context. It must be tightly regulated because there are so many things that could go wrong as, in this paper, colon cancer.

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Joe @twitskeptic.sirvin.com · 01/10/2026

From my amateur point of view, the AlphaFold predictions they used in the paper for the full protein are pretty wild, but most of it is IDRs so, with the exception of the zinc finger domain, it's all very low confidence (warm colors are uncertain).

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Joe @twitskeptic.sirvin.com · 01/10/2026

Oh, the “independent voice” first author works at OpenAI and graduated with some kind of bachelor’s degree two years ago.

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Joe @twitskeptic.sirvin.com · 01/10/2026

OpenAI put up this “independent voice” commentary on the “AI” economy” and it’s page after page of inane AI slop. Just look at these figures! And, yes, they do talk about Dyson spheres. Can’t someone make it stop? Please? openai.com/index/the-et...

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Joe @twitskeptic.sirvin.com · 01/10/2026

That's awful. So sorry to hear this.

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Joe @twitskeptic.sirvin.com · 01/10/2026

I guess these "smart, well-intentioned people" never looked at the Project 2025 report, because the destructive intent is right there in the call for cuts to the indirect-cost rate. Of course, that was struck down by the Federal courts.

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Joe @twitskeptic.sirvin.com · 01/10/2026

Me me me me … incoherent ramble vaguely related to question… me me me me …

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Joe @twitskeptic.sirvin.com · 30/09/2026

No indication of where that data will end up or what other agencies or individuals will have access to it. Of course.

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Joe @twitskeptic.sirvin.com · 29/09/2026

Elon, there in the back, was just notified that he has five more children.

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Joe @twitskeptic.sirvin.com · 29/09/2026

It's a very entertaining guilty pleasure to read. Someone should lock them all in a room and film a reality TV show where they discuss AI extinction risks.

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Joe @twitskeptic.sirvin.com · 29/09/2026

Some pretty deep thinking in that report.

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Joe @twitskeptic.sirvin.com · 29/09/2026

AIPI had funding from Jaan Tallinn, who's a big funder of Yudkowski's MIRI. Another author (Dawn Song) had a company funded by Andreessen Horowitz/a16z. It's a shame Hinton is collaborating with these people, but I think he's now in the advanced stage of Nobel disease.

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Joe @twitskeptic.sirvin.com · 29/09/2026

A coauthor of the report in that piece (Samuel Hammond) is employed by the Foundation for American Innovation. They participated in the Heritage Foundation's Project 2025. Another co-author is from the AI Policy Institute, whose co-founder had a crypto company funded by Thiel and Altman. 1/

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Joe @twitskeptic.sirvin.com · 28/09/2026

At least he'll always have those Slutcon memories.

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Joe @twitskeptic.sirvin.com · 27/09/2026

Wait, a frontier AI company may have stolen information from someone?

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Joe @twitskeptic.sirvin.com · 27/09/2026

No Slutcon for Amodei unless he calls it Super Intelligence

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Joe @twitskeptic.sirvin.com · 27/09/2026

Yes, but maybe the results from humans are worse because there’s absolutely no incentive to put any effort into it.

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Joe @twitskeptic.sirvin.com · 27/09/2026

Seems like a risk with published papers as well. Just need to deploy an agent to battle the DOS agent… 🤪

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Joe @twitskeptic.sirvin.com · 27/09/2026

If you'd arrived a month later, you might not have seen it until next spring.

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Joe @twitskeptic.sirvin.com · 26/09/2026

He also predicted in 2001 that AI would largely be solved by 2006.

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Joe @twitskeptic.sirvin.com · 26/09/2026

None of the past dire warnings - about dime novels (the "novel-reading disease"), cinema, radio, TV, "tribal" rock-and-roll) - panned out. Maybe this time will be different, but Mulgan didn't convince me of that.

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Joe @twitskeptic.sirvin.com · 26/09/2026

And Marshal McLuhan in 1951 was concerned about media and advertising based manipulation generating "prolonged mental rutting". 3/

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Joe @twitskeptic.sirvin.com · 26/09/2026

So familiar that T.S. Eliot wrote about cultural decline almost 80 years ago: 2/

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Joe @twitskeptic.sirvin.com · 26/09/2026

Mulgan follows a very familiar cognitive decline script : "during the last century, there were good reasons to believe that exactly these types of cognitive capacity were improving" followed by "now ... there are glaring signs of cognitive regression among people" 1/

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Joe @twitskeptic.sirvin.com · 25/09/2026

Hard to argue that phrases like "possibly dumber humans who are easier to manipulate" and "IQ levels began to reverse" don't imply that people are becoming stupider. Of course, these ideas have a long ignoble pedigree. And the admittedly vague idea of a "cognitive defense industry" is creepy to me.

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Joe @twitskeptic.sirvin.com · 25/09/2026

Yep, that red dot is it. The only Flock camera in NW Seattle.

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Joe @twitskeptic.sirvin.com · 25/09/2026

That’s funny , but more seriously - a home owner illegally put up a Flock ALPR camera on Seattle city owned right of way. The city issued a warning months ago and has done nothing to enforce it since. Just useless.

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TJ McIntyre @tjmcintyre.com · 24/09/2026

Muse has just dumped its entire filesystem, and the instructions include "keep a page for every person in the user's life" with "the nature of the user's relationship with this person: how close they are, what it is built on, how they act with each other, and what it seems to need right now."

neuromatch.social

jonny (nonvenomous) (@jonny@neuromatch.social)

Attached: 4 images muse's "self improvement" prompt's second point after basic memory maintenance is an instruction to, every hour, maintain a page per person that you know, and a group page for ever...

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Joe @twitskeptic.sirvin.com · 25/09/2026

Not your fault, but the headline, which is all that many people read, gives a very different impression

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Aaron Reichlin-Melnick @reichlinmelnick.bsky.social · 24/09/2026

Incredible. First Secretary Mullin claimed that DHS had identified 15,903 noncitizens on Nevada’s voter roll. Then DHS officials told a skeptical Nevada, no no no, that’s just people we flagged. Here are the names of 185 people we KNOW aren’t citizens. All 185 were citizens. DHS got 100% wrong.

When the Department of Homeland Security sent Nevada a list of 185 names last month that it claimed identified noncitizens who had been improperly allowed to register to vote, state election officials got to work.
On Tuesday, the state sent a strongly worded rebuke to the federal government: Every single person on the list was a lawful citizen.
"As for the 185 individuals, our records indicate that they were citizens," Greg D. Ott, a deputy attorney general in Nevada, wrote, according to a copy of a letter sent to Department of Homeland Security officials obtained through open records requests.
"You have provided nothing of substance to suggest otherwise."

Following the meeting, Ms. Vogt sent a clarifying email to Nevada officials. "I also wanted to be sure I clarified that we did not reduce the 15,903 to 185," she wrote. "We've manually reviewed some of the 15,903 and confirmed 185 are not U.S. Citizens."
Now, Nevada officials are saying even that 185 number is wrong. They also took issue with a letter D.H.S. sent them in early September, in which the agency reiterated its initial claims about nearly 16,000 noncitizens on the rolls and pressured state officials to review each case in a letter to Nevada officials in early September.

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Joe @twitskeptic.sirvin.com · 24/09/2026

I think it's troubling that their technical report states that Claude discovered "RTs with tandem repeat arrays" while their press release calls it a "novel enzyme system". Did they verify any enzyme functionality? It seems they only verified that the array is transcribed into discrete RNAs.

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Allison Gill @muellershewrote.com · 24/09/2026

The cervical punch biopsy and colposcopy was easily the worst pain I’ve felt in my entire life.

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Steven Mazie @stevenmazie.bsky.social · 24/09/2026

It’s short and sweet. TLDR: asked and answered. No lower court can abrogate an order of the Supreme Court

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Joe @twitskeptic.sirvin.com · 23/09/2026

Brilliant strategy by Newsom and Bonta

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Justin Baragona @justinbaragona.bsky.social · 23/09/2026

Welp. According to Semafor, David Ellison has discussed bringing Elon Musk on as an investor in Paramount's merger with Warner Bros., which could mean Musk could have a stake in CBS News and CNN. www.semafor.com/article/09/2...

semafor.com

Exclusive: Paramount weighs tapping Musk for equity investment

A cash injection from SpaceX billionaire Elon Musk could reduce investor Larry Ellison’s financial burden and bolster the deal’s investor base.

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Joe @twitskeptic.sirvin.com · 23/09/2026

Seems like there’s a new gene regulation wrinkle coming out every day now.

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Joe @twitskeptic.sirvin.com · 21/09/2026

Still amazed that scientists are willing to turn over their best ideas to companies that used stolen IP to train their models. Might want to add that to some of these puff pieces

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Joe @twitskeptic.sirvin.com · 21/09/2026

Is there a public source for that route? I'm going to be in Copenhagen in early November and would be quite interested in checking that out.

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Aaron Reichlin-Melnick @reichlinmelnick.bsky.social · 21/09/2026

NEW: @apnews.com confirms that ICE has begun electronically "disappearing" people in the agency's custody who have final orders of removal. As of last week, anyone jailed by ICE with a final order of removal will NOT appear in the ICE Online Detainee Locator System, making them effectively vanish.

apnews.com

AP Exclusive: ICE hides locations of thousands of detainees with final removal orders

U.S. Immigration and Customs Enforcement has stopped publicly revealing where it is holding most detainees who are subject to final deportation orders, in a move that has made it harder for lawyers an...

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Joe @twitskeptic.sirvin.com · 21/09/2026

Renaissance man/founder contemplating late philosopher Daniel Dennett’s take on evolution during his recursive self improvement training.

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Joe @twitskeptic.sirvin.com · 21/09/2026

This cyclical state transition diagram from W <-> Z is probably worth a billion $.

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Joe @twitskeptic.sirvin.com · 21/09/2026

Nothing like a clear whiteboard to demonstrate that these startup bros are on to something and Cade Metz is on it. www.nytimes.com/2026/09/16/s...

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