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Tomas Machacek

@trichotom.bsky.social
76 followers 80 following 42 posts

Parasitic worms & immunity. 🪱🔬 Avian & human schistosomes. 🐭🦆 Swimmer's itch (www.cerkarie.cz), lungs & liver granulomas. 🏊🏻‍♂️🫁 Assistant professor at @sciencecharles.bsky.social.🎓 Secretary of @parazitologiecz.bsky.social. 🗒️

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Tomas Machacek @trichotom.bsky.social · 19/06/2026
Je tu první pořádný slunečný víkend ☀️ A tak preventivně připomínáme infoweb k cerkáriové dermatitidě, vyrážce z koupání v přírodních vodách 🏊🏻‍♂️🤭 www.cerkarie.cz
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Tomas Machacek @trichotom.bsky.social · 16/06/2026
I've heard a lot about these signs that highlight dog roundworm risk in Dublin’s public parks. Finslly spotred them personally... 🐕💩😁
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Tomas Machacek @trichotom.bsky.social · 04/06/2026
First evidence of biofluorescence in the fire salamander! 🖤💛 Under UV light, they show striking blue-green and yellow fluorescence in their skin, glands, and secretions. 🦎✨🌟 @royalsociety.org royalsocietypublishing.org/rsos/article...
royalsocietypublishing.org
Glandular biofluorescence in fire salamanders (Salamandra salamandra): first evidence and ecological implications
Abstract. With advances in imaging technologies and the growing availability of specialized lights and cameras, biofluorescence is increasingly recognized
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Ai Ing Lim @aiinglim.bsky.social · 07/05/2026
We found maternal helminth infection can promote antiviral immunity in offspring 🤱🪱 www.cell.com/cell-host-mi... Don’t worry, we are not suggesting we reinfect everyone with worms! Instead, we identified a microbiota-derived metabolite, Indole-3-propionic acid, that enhances antiviral immunity!
cell.com
Maternal helminths rewire the microbiota to promote offspring antiviral immunity
Fernandes et al. show that maternal helminths, long-standing mammalian partners, confer antiviral immunity to offspring via the microbiota-derived metabolite indole-3-propionic acid (IPA). This work r...
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Tomas Machacek @trichotom.bsky.social · 17/05/2026
Schistosome eggs are not the same in the liver and the intestine 🥚🦠 Following our previous “winners & losers” story, we now provide additional evidence by analyzing proteins released by eggs across different tissues! 🔬🧪 www.frontiersin.org/journals/cel...
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Tomas Machacek @trichotom.bsky.social · 08/04/2026
Attending @bspparasitology.bsky.social Spring Meeting remotely this time 🥲 Not ideal, but still excited to share our latest work on Schistosoma mansoni egg secretome directly in the host tissues! 🔬 🚨 Key message: liver is not intestine 😏
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Tomas Machacek @trichotom.bsky.social · 22/12/2025
PF 2026 🥳 @parazitologiecz.bsky.social
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Tomas Machacek @trichotom.bsky.social · 03/12/2025
@charlesuni.cuni.cz is ready 💪🏻🎄
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Tomas Machacek @trichotom.bsky.social · 26/11/2025
@pnas.org Tattoo ink doesn’t just stay in the skin. 🎨 It drains into lymph nodes (kinda expected), where it can persist for months. 🤔 Ink-loaded macrophages trigger long-term inflammation and can alter vaccine responses. 💉 www.pnas.org/doi/10.1073/...
pnas.org
Tattoo ink induces inflammation in the draining lymph node and alters the immune response to vaccination | PNAS
Despite safety concerns regarding the toxicity of tattoo ink, no studies have reported the consequences of tattooing on the immune response. In thi...
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Tomas Machacek @trichotom.bsky.social · 14/11/2025
Happy to contribute to the Parasite of the Month series in @cp-trendsparasitol.bsky.social with our article on the neurotropic schistosome Trichobilharzia regenti! 🧠🔬 authors.elsevier.com/a/1m5yH5Eb1x...
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Tomas Machacek @trichotom.bsky.social · 21/10/2025
Where would the Arabs have reached if not for the plague that decimated the Byzantine Empire? And how did malaria influence the fight for American independence? 🤔 A light yet fascinating read about the germs that shaped our past — a perfect blend of infection and history. 📖🦠
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Tomas Machacek @trichotom.bsky.social · 18/09/2025
Skin-penetrating nematodes rely on dopamine signaling to invade their hosts. Blocking dopamine signalization could stop infections before they start. 🔬 @natcomms.nature.com 🔗 www.nature.com/articles/s41...
nature.com
Dopamine signaling drives skin invasion by human-infective nematodes - Nature Communications
Skin-penetrating nematodes infect hosts by burrowing through host skin. This study finds that in the human-parasitic, skin-penetrating nematode Strongyloides stercoralis, skin penetration behavior is ...
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Tomas Machacek @trichotom.bsky.social · 16/09/2025
New study out! 🚨 For the first time, we tracked Trichobilharzia franki, a major cause of swimmer’s itch in Europe, in the lab. 🪱🔬 From genetics to pathology & immunity, our findings shed new light on this tricky parasite and its role in outbreaks. doi.org/10.1016/j.fa...
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Dr Joanne Power @hanniepower.bsky.social · 11/09/2025
Save the dates!! @bspparasitology.bsky.social Spring Meeting 2026 will be in Bonnie Glasgow! 7-9 April 2026, with a drinks reception in Glasgow City Chambers on the 6th of April 2026! Keep an eye on the BSP website for registration and abstract submission! Logo by @shannaraeilean.bsky.social! 🦟
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Tomas Machacek @trichotom.bsky.social · 15/09/2025
Cool meeting at @sciencecharles.bsky.social right now! 🪱🔬
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Tomas Machacek @trichotom.bsky.social · 12/09/2025
Second stop of our @4euplusalliance.bsky.social project: Denmark! 🇩🇰🐌🦆 We sampled in various sites – even right in the heart of Copenhagen! 🌊🏙️ Great teamwork, hands-on training, and more data for our #eDNA detection of swimmer’s itch. 🧬 @zikmund.bsky.social 🔗 natur.cuni.cz/en/biology/d...
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Judi Allen @profjudiallen.bsky.social · 07/09/2025
Truly a most neglected tropical disease. More common than other filarial nematode diseases and yet largely ignored. www.cell.com/trends/paras...
cell.com
Mansonella perstans – the forgotten filaria
Mansonella perstans is the most prevalent human filarial parasite, infecting over 100 million people worldwide. Despite its wide distribution, it remains one of the most neglected parasitic infections...
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Tomas Machacek @trichotom.bsky.social · 07/09/2025
Thelazia callipaeda is an emerging zoonotic nematode responsible for eye infections. A new human case is reported from Rome, Italy. 👁️🪱🍕 @crpvbd.bsky.social doi.org/10.1016/j.cr...
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Tomas Machacek @trichotom.bsky.social · 07/09/2025
Possibly a new species of Leucochloridium from Japan... I really love these creatures! 😍 doi.org/10.1016/j.pa...
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Nic Wheeler @wheelerlab.bio · 21/08/2025
I am pleased to present a project we've been working on for the least year to try to answer a fundamental question - does a parasite's developmental niche as an egg have effects on larval stages? We show that the answer is very much yes - which has a few implications. www.biorxiv.org/content/10.1...
biorxiv.org
Tissue-specific distribution of eggs in the definitive host drives transcriptomic and behavioral differences in Schistosoma mansoni miracidia
Schistosomiasis is a neglected tropical disease caused by human-infective schistosomes (Trematoda: Schistosoma). Intestinal schistosomiasis in sub-Saharan Africa and the Neotropics is caused primarily...
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Adam Hayward @adhayward.bsky.social · 12/08/2025
Absolute pleasure to be involved in this review article on sustainable parasite control in ruminants. Full of lovely stuff on vaccines, nutrition, genetics, grazing and biological control! www.sciencedirect.com/science/arti...
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Tomas Machacek @trichotom.bsky.social · 12/08/2025
Don't miss this opportunity!
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Tomas Machacek @trichotom.bsky.social · 10/08/2025
First stop of our @4euplusalliance.bsky.social project: Poland! 🐌🦆 We met with @ankarn.bsky.social (thank you! 🙏🏻) to exchange knowledge on bird schistosomes and swimmer's itch and, mainly, share our experience with water filtration and #eDNA detection. 🧬
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Parasite - The Journal @parasitejournal.bsky.social · 01/08/2025
New paper today: Isolation of Toxoplasma gondii from the placenta of northern fur seals (Callorhinus ursinus) and potential transplacental transmission of the parasite 🧪 doi.org/10.1051/para...
Morphology of the placenta and samples from fur seal #2. A: Stillborn and placental tissue in 2017. B: Placenta in 2022. C: Zonary and belt-shaped placenta, dam, and its pup. D: Magnified C: surface of the chorioallantoic membrane.
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Emma Houlder @emmahoulder.bsky.social · 31/07/2025
In schistosome 🪱-endemic areas, people are repeatedly reinfected — but we still don’t fully understand how T cell responses develop in these cycles. In my first ever last-author paper (😱) we investigate this, comparing endemic and repeat controlled human schistosome infection: rdcu.be/exH58
rdcu.be
T cell responses in repeated controlled human schistosome infection compared to natural exposure
Nature Communications - In schistosomiasis-endemic regions, the cyclical nature of infection and treatment complicates understanding of host immune responses. Repeated controlled human Schistosoma...
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Tom Pennance @schistosoma.bsky.social · 27/07/2025
New research w/ @jacobphd.bsky.social et al. published today in Nature Communications: Genes linked to schistosome resistance identified in a genome-wide association study of African snail vectors doi.org/10.1038/s414... 🐌🪱🧬
doi.org
Genes linked to schistosome resistance identified in a genome-wide association study of African snail vectors - Nature Communications
A genome wide association study of an African vector of schistosomiasis revealed two genomic regions associated with resistance to Schistosoma mansoni. These findings will inform novel control strateg...
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Tomas Machacek @trichotom.bsky.social · 15/07/2025
🔬 Věda má smysl, když pomáhá v praxi! Vyvíjíme proto metodu pro rychlou detekci původců cerkáriové dermatitidy pomocí #eDNA. 🦆🐌🏊🏻 Honza a Jana to skvěle vysvětlují v reportáži @radiozurnal.bsky.social – díky! 📻 📍 @sciencecharles.bsky.social @ukforum.cuni.cz 🔗 radiozurnal.rozhlas.cz/ptaci-motoli...
radiozurnal.rozhlas.cz
Ptačí motolice umí vědci ve vodě odhalit pomocí filtru DNA. Nová metoda je efektivnější i bezpečnější
Když vylezete v přírodě z vody a na těle se vám do večera objeví drobné červené skvrnky, zpozorněte. Mohlo by se jednat o cerkáriovou dermatitidu. Stojí za ní larvy ptačích motolic. Do vody se dostáva...
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Tomas Machacek @trichotom.bsky.social · 26/06/2025
📢 A major study on alveolar echinococcosis 🦊🫐🪱 in Europe reveals over 4,200 human cases, with hotspots in the Alps and Baltics. @thelancetinfdis.bsky.social www.thelancet.com/journals/lan...
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Tomas Machacek @trichotom.bsky.social · 26/06/2025
A very cool study on the man-o’-war, also known as bluebottle (Physalia). 🌊 The iconic creature is not just one species; it is at least four! 🪼🌍 Despite drifting across vast oceans, they don't mix freely. @currentbiology.bsky.social www.cell.com/current-biol...
cell.com
Population genomics of a sailing siphonophore reveals genetic structure in the open ocean
Church et al. use population genomics and citizen-science photos to show that Physalia comprises at least four genetically distinct, morphologically recognizable species, each with substantial substru...
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Tomas Machacek @trichotom.bsky.social · 19/06/2025
S nástupem letních teplot se nám začínají objevovat první případy cerkáriové dermatitidy (vyrážky z koupání). Víme už o dvou lokalitách ve Středních Čechách. ☀️🏊🏻‍♂️ Tak je možná fajn tu připomenout web pro veřejnost, který jsme k tématu připravili: www.cerkarie.cz 😉
cerkarie.cz
Cerkárie.cz
Cerkáriová dermatitida Cerkáriová dermatitida (jinak také svědivá vyrážka z koupání nebo v angličtině „swimmer’s itch“) je alergická kožní reakce způsobená larvami (cerkáriemi) ptačích motolic, které ...
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Tomas Machacek @trichotom.bsky.social · 30/05/2025
New publication out today! 🥳 Honza and @zikmund.bsky.social developed a sensitive molecular toolkit for detecting bird schistosomes, the main culprits behind swimmer’s itch. 🏊🏻🐌 A step forward in molecular surveillance of bird schistosomes! @sciencecharles.bsky.social 🔗 doi.org/10.1186/s130...
doi.org
Molecular detection and identification of Trichobilharzia: development of a LAMP, qPCR, and multiplex PCR toolkit - Parasites & Vectors
Background Cercarial dermatitis (CD), or swimmer’s itch, is a water-borne allergic skin reaction caused by the penetration of the larval stages of bird schistosomes (cercariae) into the skin. Members ...
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Tomas Machacek @trichotom.bsky.social · 23/05/2025
@nature.com surveyed over 5k researchers worldwide on the ethics of using AI in scientific writing. Great community-based study. www.nature.com/articles/d41...
nature.com
Is it OK for AI to write science papers? Nature survey shows researchers are split
Poll of 5,000 researchers finds contrasting views on when it’s acceptable to involve AI and what needs to be disclosed.
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Tomas Machacek @trichotom.bsky.social · 25/04/2025
▶️ More and more Alzheimer’s researchers, including former skeptics, are opening up to the possibility that infection contributes to neurodegeneration. 🧠 Happy to see this comment on the Alzheimer's disease infectious hypothesis published in @nature.com. 🔗 www.nature.com/articles/d41...
nature.com
Do infections have a role in Alzheimer’s disease?
The suggestion that pathogens play a part in driving dementia is not as niche as it once was, but the evidence remains inconclusive.
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Tomas Machacek @trichotom.bsky.social · 20/04/2025
▶️ Bacterial skin infection does not just affect your skin. It can mess with your systemic immunity! 😮 The study shows how it changes eosinophils in the bone marrow, leading to long-lasting effects on allergic reactions and lung inflammation. 🔗 www.science.org/doi/10.1126/...
science.org
Eosinophil innate immune memory after bacterial skin infection promotes allergic lung inflammation
Staphylococcus aureus skin infection induces eosinophil innate immune memory to exacerbate allergen-induced airway inflammation.
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Tomas Machacek @trichotom.bsky.social · 11/04/2025
We were curious about claims linking dog roundworms (causing human larval toxocarosis ☝🏻) to Alzheimer’s disease 🧠🐶. However, no AD-like pathology was found in the mouse model. Sometimes, negative results are welcome! 😅 👉 @parasitejournal.bsky.social 🔗 www.parasite-journal.org/articles/par...
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Tomas Machacek @trichotom.bsky.social · 27/03/2025
Octopus males use a high-precision bite that targets the female’s aorta to inject deadly neurotoxin at the start of copulation! 😮🐙 @currentbiology.bsky.social 🔗 doi.org/10.1016/j.cu... 📷: Totti, CC BY-SA 4.0
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Tomas Machacek @trichotom.bsky.social · 21/03/2025
Don't miss this wormy meeting! 🔜 Only 9 days left before early bird registrations close. @parazitologiecz.bsky.social 👀 hd2025.natur.cuni.cz
hd2025.natur.cuni.cz
HD 2025 | May 12-16
Dear Helminthologists, We would like to invite you to participate in the 29th Helminthological Days, which will take place in the Kostelec nad Černými lesy from May 12 to May 16, 2025. The venue of t...
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Tomas Machacek @trichotom.bsky.social · 13/03/2025
Can neurotropic dog roundworms contribute to Alzheimer’s disease? 🐶🧠 Our mouse study provides new insights into this long-debated question! 🤔 #parasitology #neurology #Alzheimers
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Tomas Machacek @trichotom.bsky.social · 12/03/2025
New tools for environmental detection of swimmer's itch presented by Honzik from our lab! 🏞🧬 #eDNA #LAMP
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Tomas Machacek @trichotom.bsky.social · 12/03/2025
@lukykony.bsky.social sharing nice data on enignatic VAL proteins in schistosomes. 🤩 Happy to add some pieces to the project!
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Tomas Machacek @trichotom.bsky.social · 11/03/2025
Happy to be at the parasitology joint meeting in Würzburg! Thanks to all organizers! 🇩🇪🇬🇧🇨🇭 @bspparasitology.bsky.social
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Tomas Machacek @trichotom.bsky.social · 06/03/2025
What a great cover image! 😍
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Tomas Machacek @trichotom.bsky.social · 16/02/2025
Uploading memories, September 2020. They said 'yes'... #viva #passed 👨🏻‍🎓
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