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Tim Frayling

@timfrayling.bsky.social

747 followers 210 following 183 posts

Human genetics, type 2 diabetes and obesity in today's environment. Cycling uphill. Team science. New shoots in Geneva & France, long roots in the UK & Exeter. www.unige.ch/medecine/gede/en/resea…

Posts Replies Media

Tim Frayling @timfrayling.bsky.social · 20/03/2026

Update from Claude

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Tim Frayling @timfrayling.bsky.social · 14/01/2026

Learning more about the brilliance of the medical record data at the University Hospital Geneva. This plot, from pubmed.ncbi.nlm.nih.gov/34643542/ shows how medical informatics researchers have introduced , & clinicians passively adopted, a set list of phrases, reducing new free text.

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Tim Frayling @timfrayling.bsky.social · 26/05/2025

3 euros 60. The change from a 5 euro note after purchasing an excellent coffee americano in Milan.

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Tim Frayling @timfrayling.bsky.social · 07/05/2025

The GEMINI team: a fantastic group of researchers using multiple multi-modal primary care and genetic datasets to help understand 2546 pairs of long term common conditions. #MLTC

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Tim Frayling @timfrayling.bsky.social · 19/03/2025

thanks again to Zoltan and the Lausanne team.

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Tim Frayling @timfrayling.bsky.social · 19/03/2025

Update from the Geneva Common Disease Genetics and Genomics team. Welcoming newcomer Anna Ramisch with a day out visiting the super smart Kutalik team in Lausanne. And some sunny early Springtime Alps as a backdrop. That's the dream team of Aurélie, Liza, Lauric, some old bloke and Anna (l to r).

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Tim Frayling @timfrayling.bsky.social · 18/02/2025

Here's the data. Can someone let Nigel Farage, Marine le Pen, the AFD, etc etc know ? Not just the numbers themselves, but even worse for the shift towards older populations relying on fewer younger people in the workforce.

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Tim Frayling @timfrayling.bsky.social · 06/02/2025

Here's a screenshot of the app: browse around 2546 pairs Shared genetics on the X, primary care co-occurrence on the Y axis:

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Tim Frayling @timfrayling.bsky.social · 21/11/2024

And here is the additive effect between your Educational attainment Polygenic score and your burden of rare variants in DD genes (some noisiness in those with 3 damaging DD rare variants as fewer of them) www.nature.com/articles/s41...

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Tim Frayling @timfrayling.bsky.social · 21/11/2024

And the idea of “phenotypic outliers”: e.g. those reported having no qualifications recorded despite having an EA PGS in the top decile were more likely to be rare DD variant carriers.

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Tim Frayling @timfrayling.bsky.social · 21/11/2024

For example, among carriers of rare DD variants, those with a DD-related diagnosis had a substantially lower Educational attainment PGS than those without a clinical diagnosis. The liability model in action – your adverse polygenic background “pushes you into the clinic” if you have a rare variant

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Tim Frayling @timfrayling.bsky.social · 13/11/2024

First bluesky post. A picture of blue sky near Geneva. And a small prediction : lots of exciting times ahead in human genetics based research and healthcare

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