Reposted by Erik Garrison
see also this work, which helps provide some helpful framing of how novel these phages are: www.biorxiv.org/content/10.6...
tl;dr: I believe this work generates only marginally novel phages, which have only a moderate likelihood of working, that decreases the more novel they get.
biorxiv.org
Quantifying evolutionary novelty and design efficiency in generative genome design
Generative genome design models can now produce previously unobserved genome-length sequences, but assessing their capabilities is complicated by limitations in functional prediction. The ability to e...