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Ken Milne MD @thesgem.bsky.social · 04/10/2026

IST-3 is the largest RCT of IV tPA for acute ischemic stroke & contributes substantially to SRMAs & guidelines. Concerns persist regarding potential bias arising from missing 6-month Oxford Handicap Scale data. link.springer.com/article/10.1... #MedSky

link.springer.com

Assessment of bias in the third international stroke trial (IST-3) - BMC Medical Research Methodology

Background The Third International Stroke Trial (IST-3) is the largest randomized controlled trial (RCT) of intravenous alteplase for acute ischemic stroke and contributes substantially to meta-analys...

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