Precisely defining transcription unit boundaries across eukaryotic genomes is fundamental to understanding individual gene function and regulation. The multifaceted process of RNA 3' end formation es…

Estell and Łazowski et al. show that Integrator and Restrictor form distinct pathways for early attenuation of RNA polymerase II: Integrator acts at the promoter-proximal pause site, whereas Restricto...

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A protein that suppresses noncoding RNA emerges as a guardian of genome stability.

Kelley et al. discover that the PNUTS phosphatase complex plays an essential role in gene transcription by controlling RNA polymerase II pause release. PNUTS achieves this through its TND, which recog...