Mathew Pletcher @thepetridish.bsky.social · 15/10/2026@thepressbox.bsky.social Surprised that New Hampshire and Iowa didn’t make the list. Feels like NH is at risk (slightly better for Dems than Maine on your tiers) and Iowa is ahead of Kansas. 000 0
Mathew Pletcher @thepetridish.bsky.social · 12/09/2026What a perfect place to spend a cool September evening. 001 1
Mathew Pletcher @thepetridish.bsky.social · 22/08/2026Can we, for the love of all that is holy, stop playing Henry Davis? I think the sample size is large enough. The guy can’t hit major league pitching. 000 0
Mathew Pletcher @thepetridish.bsky.social · 19/08/2026It is starting to feel like Twitter around here. In that I am now routinely getting followed by bots. 000 0
Reposted by Mathew PletcherCineCalendar @cinecalendar.bsky.social · 14/07/2026Happy July 14th to all who celebrate! #ConAirDay 07730 77
Mathew Pletcher @thepetridish.bsky.social · 17/05/2026I don't get this effort to event-ize the NFL schedule release. We know who each team is playing next season as soon as the previous season ends. It isn't a surprise. I just don't see this ever becoming a thing, unlike the draft, no matter how much the league spends. 100 1
Reposted by Mathew PletcherBejaLabTechnion @bejalab.bsky.social · 11/05/2026Pooled CRISPRi screening reveals fungal-specific drug target candidates www.nature.com/articles/s41...nature.comPooled CRISPRi screening reveals fungal-specific drug target candidates - Nature MicrobiologyThis study presents a pooled CRISPRi screening approach in Candida albicans to investigate essential genes at scale, revealing environment- and strain-dependent gene sensitivities and conserved vulner... 072 7
Reposted by Mathew PletcherJason Mast @jasonmast.bsky.social · 11/05/2026Five years after disaster, a rare disease community gets new chance at treatment www.statnews.com/2026/05/11/a... via @statnews.comstatnews.comFive years after disaster, a rare disease community gets new chance at treatmentSome boys had astonishing recoveries. But other boys died. Now Astellas is returning to revised gene therapy for XLMTM. 052 5
Mathew Pletcher @thepetridish.bsky.social · 01/05/2026One of the absolute highlights of my graduate school career was whem we got access to the Celera database. I spent many happy days browsing the genome on a gene hunting expedition. cen.acs.org/people/obitu...cen.acs.orgJ. Craig Venter, foil of the Human Genome Project, dies at 79He helped develop the technique of whole-genome shotgun sequencing, still widely used today 000 0
Mathew Pletcher @thepetridish.bsky.social · 13/04/2026Throughout my childhood, this guy was baseball for me. Never the star but could do alot of stuff pretty well. Ole’ Scrap Iron was the definition of the gritty/gutty ballplayer. Phil Garner was an All-Timer. apnews.com/article/phil...apnews.comFormer major league infielder Phil Garner, who managed Astros' first World Series team, dies at 76Phil Garner, a three-time All-Star infielder who went on to manage the Houston Astros to their first World Series appearance, has died. He was 76. 000 0
Mathew Pletcher @thepetridish.bsky.social · 10/04/2026Middle relief needs a little help too. But glad to see Cruz hitting again. And if Griffin can get going combined with our studly starting pitching, we could be in for some fun. 000 0
Mathew Pletcher @thepetridish.bsky.social · 10/04/2026Really enjoying this year’s iteration of the Pirates. The line-up still needs a bit more pop but Lowe and O’Hearn have been solid additions (can we cut bait on Ozuna yet). This could be the year…to finish above 500. 000 0
Mathew Pletcher @thepetridish.bsky.social · 03/04/2026I love a good map. I LOVE, love a good map of a fictional location. I could study this for hours. 000 0
Mathew Pletcher @thepetridish.bsky.social · 27/02/2026As years pass and memories fade, one childhood moment remains as crisp as always. And that is a birthday trip w/ friends to McD’s to get these UFO Happy Meals. 010 1
Reposted by Mathew PletcherRetroist @retroist.com · 21/02/2026The Legend of Zelda is 40 years old today. It came out in 1986 for the NES, and when it showed up at friend’s place, you knew it. We all gathered around the TV, someone had a notebook for secrets and maps, and afternoons turned into an adventures. www.retroist.com/p/retroist-l... 24712 47
Mathew Pletcher @thepetridish.bsky.social · 18/02/2026Great night for some basketball in Austin. 000 0
Reposted by Mathew PletcherAndrew Kurjata @akurjata.ca · 21/01/2026I need you to see what is going on on Murdoch Mysteries these days 1920044 200
Reposted by Mathew PletcherEndpoints News @endpts.com · 15/01/2026Ocugen reported interim Phase 2 data showing its gene therapy reduced lesion size in geographic atrophy patients, though results came from a small subset of the trial.endpoints.newsOcugen unwraps mid-stage data for eye disease gene therapyEye disease gene therapy developer Ocugen reported positive interim Phase 2 data for its geographic atrophy program from a small number of patients. 011 1
Mathew Pletcher @thepetridish.bsky.social · 05/01/2026Pretty close. Now we get a chance to see if the other half of this prediction comes true. 000 0
Mathew Pletcher @thepetridish.bsky.social · 02/01/20269. Predator: Badlands 8. The Naked Gun (2025) 7. Life of Chuck 6. F1 5. Thunderbolts* 4. Wake Up Dead Man 3. KPop Demon Hunters 2. Cunk on Life 1. Good Fortune Good Fortune should have been much bigger. Keanu was outstanding. 000 0
Mathew Pletcher @thepetridish.bsky.social · 02/01/20266. The Penguin: S 1 (HBOMax) 5. Pluribus: S 1 (Apple) 4. The Pitt: S 1 (HBOMax) 3. Shoresy: S 4 (Hulu) 2. Étoile: S 1 (Prime) 1. Andor: S 2 (Disney+) Andor was so good. Stood out beyond anything else I watched this year. The cancellation of Étoile was the disappointment of the year. 000 0
Mathew Pletcher @thepetridish.bsky.social · 02/01/202613. Elsbeth: S 2 (Paramount+) 12. Only Murders in the Building: S 5 (Hulu) 11. Michelle Wolf: The Well (Netflix) 10. Death by Lightning (Netflix) 9. Stranger Things: S 5 (Netflix) 8. A Thousand Blows: S 1 (Hulu) 7. Paradise: S 1 (Hulu) 000 0
Mathew Pletcher @thepetridish.bsky.social · 02/01/2026My top 20 shows I watched this year (regardless of when they originally aired). 20. The Recruit: S 2 (Netflix) 19. The Residence: S 1 (Netflix) 18. Creature Commandos: S 1 (HBOMax) 17. Iron Heart: S 1 (Disney+) 16. 99 to Beat: S 1 (Hulu) 15. English Teacher: S 2 (Hulu) 14. Deli Boys: S 1 (Hulu) 010 1
Mathew Pletcher @thepetridish.bsky.social · 02/01/2026My favorite 15 movies I watched this year (does not include rewatches of classics I already know and love - i.e. Die Hard). 15. Novacaine 14. Wicked: For Good 13. Tron: Ares 12. Accountant 2 11. Hundreds of Beavers 10. Superman 000 0
Mathew Pletcher @thepetridish.bsky.social · 27/12/2025Watching the Penn St. v. Clemson game. Kind of depressing that all the announcers can talk about are the players that aren’t playing. 000 0
Mathew Pletcher @thepetridish.bsky.social · 11/11/2025From Allyson Berent of FAST. “What you think we want may not be what we want. The risk we are willing to accept may not be the risk you think we are willing to take. Ask us” paraphrased 000 0
Mathew Pletcher @thepetridish.bsky.social · 11/11/2025#GATC2025 finishes with the patient perspective. Emphasizing that this is a partnership. All considerations of risk needs to be contextualized by the patients needs. Transparency is a must. 000 0
Mathew Pletcher @thepetridish.bsky.social · 11/11/2025Said that we are past Era 1 (treating Rare Disease) and need to focus on how to bring it the tech to larger more complex diseases. Very clear articulation of what the Rare Disease community has been seeing (as sad as it is). Rare Disease is not something they are focused on. 000 0
Mathew Pletcher @thepetridish.bsky.social · 11/11/2025Really helpful presentation by Sylke Poehling from #Roche that nicely encapsulated the thinking by Big Pharma on #genetherapy. #GATC2025 000 0
Mathew Pletcher @thepetridish.bsky.social · 11/11/2025George Church reminds us that we went 7 months from diagnosis to cure for baby KJ. It can be done but scaling beyond this rare one offs still escapes us. #GATC2025 000 0
Mathew Pletcher @thepetridish.bsky.social · 11/11/2025To paraphrase Sonia, what we are truly up against in accessing treatments are arbitrary decisions by individual people. Patients should have the choice to access these treatments. #GATC2025 000 0
Mathew Pletcher @thepetridish.bsky.social · 11/11/2025Put on partial clinical hold while asking for an additional monkey study despite having robust data in other species. And lacking the money for that monkey study, that partial hold becomes a permanent hold. 000 0
Mathew Pletcher @thepetridish.bsky.social · 11/11/2025Sonia Vallabh speaking to the heart of the patient experience. Often told there is nothing you can do while your genetic information is actively kept from you. #GATC2025 000 0
Mathew Pletcher @thepetridish.bsky.social · 11/11/2025Genetic Agency - the concept that patients should be provided the option to access the genetic medicines that could make a difference in their lives - but how do we make it happen? 000 0
Mathew Pletcher @thepetridish.bsky.social · 11/11/2025Eric Kelsic of Dyno Tx kicking off what should be an interesting day discussing the concept of genetic agency. 000 0
Reposted by Mathew Pletcherkottke.org @kottke.org · 16/04/2024Eric Topol interviews Jennifer Doudna on the bright future of genome editing therapy in curing disease (Apple Podcasts). There’s an FDA-approved CRISPR therapy for sickle cell disease out now with others to come. [youtube.com]youtube.comJennifer Doudna: The Exciting Future of Genome EditingThe most significant life science breakthrough of our time is just getting started. Subscribe for more Ground Truths: https://erictopol.substack.com/ 0118 11
Mathew Pletcher @thepetridish.bsky.social · 08/10/2025@thepressbox.bsky.social While I have your attention…You talk a lot about the crumbling business model of traditional media. I would be interested in hearing about the new models that meet the moment and you think could provide a path forward. 000 0
Mathew Pletcher @thepetridish.bsky.social · 08/10/2025@thepressbox.bsky.social If you are putting together an evolutionary tree of Sports Center anchors, isn’t Bob Ley at the top? Representing the CNN of sports concept that started the channel. 100 1
Mathew Pletcher @thepetridish.bsky.social · 01/10/2025I guess I missed the announcement of the new candy corn tariff. 010 1
Reposted by Mathew PletcherMatthew Herper @matthewherper.bsky.social · 24/09/2025Great news! Experimental gene therapy for Huntington’s markedly slowed disease progression in key trial www.statnews.com/2025/09/24/h... via @statnews.comstatnews.comExperimental gene therapy for Huntington’s markedly slowed disease progression in key trialAn experimental gene therapy slowed the progression of Huntington’s disease by 75% after three years — study results likely to support the first approval of a genetic treatment for the condition. 04812 48
Mathew Pletcher @thepetridish.bsky.social · 18/08/2025I, for one, will not repeat the sins of my parents and visit this agony on my own offspring. 000 0
Mathew Pletcher @thepetridish.bsky.social · 18/08/2025It is irresponsible to allow your kid to believe the Pirates are a legitimate team purposefully trying to win. Like believing in the Tooth Fairy. 030 3
Reposted by Mathew PletcherThe Onion @theonion.com · 18/08/2025Pirates Under Fire For Directly Marketing Team To Children theonion.com/pirates... 101012130 1K
Reposted by Mathew PletcherRobert Coffin @robertcoffin.bsky.social · 19/07/2025Re $SRPT, huge doses are used, for Elevidys approx 10exp16 genomes for 70kg+, 100x > # of cells in the human body, or an MOI of 100 for every cell the patient has, ie trying to force AAV to do something it's not really capable of: Is it really surprising if tox issues may result? 023 3
Mathew Pletcher @thepetridish.bsky.social · 23/06/2025“It’s unconscionable that it now will take even longer for the FDA to rule on this drug for our very small population with no other specific therapies,” Barth Syndrome Foundation executive director Emily Milligan said in a statement. endpoints.news/fda-rejects-...endpoints.newsFDA rejects Stealth's rare disease drug, but offers potential for accelerated approvalAfter a slight delay, the FDA rejected Stealth BioTherapeutics' Barth syndrome drug application for elamipretide, but will consider a resubmission via the accelerated approval pathway. 010 1
Mathew Pletcher @thepetridish.bsky.social · 05/06/2025Noooooooo! I guess I get to take this year off from following football. Or is this a secret plan to finally bottom out the team so we can get a high draft pick and get a real QB? 000 0
