Reposted by Han
Strong base & alkyl halide in one flask usually triggers messy side reactions. The new @angewandtechemie.bsky.social paper from @thenewmanlab.bsky.social shows a way around it: using TMDSO & KOtBu to achieve direct, single pot C(sp3)-H alkylation! onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Deprotonation and Alkylation of Weakly Acidic C(sp<sup>3</sup>)─H Bonds Through In Situ Generation of a Strong Hydride Base From 1,1,3,3‐Tetramethyldisiloxane and Potassium <i>tert</i>‐Butoxide
The use of 1,1,3,3-tetramethyldisiloxane (TMDSO) and potassium tert-butoxide enables direct alkylation of weakly acidic carbon–hydrogen bonds with alkyl halides. Experimental and computational studie...
