iiinova — where your digital self keeps evolving

The Babak Lab @thebabaklab.bsky.social · 30/09/2026

A major limitation of many antibody–drug conjugates (ADCs) and small molecule–drug conjugates (SMDCs) is their dependence on receptor-mediated endocytosis: the drug must enter the cell before releasing its payload. Link in the comments 👇

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The Babak Lab @thebabaklab.bsky.social · 28/09/2026

The @fda.gov has approved Tudriqev (vusolimogene oderparepvec-wtpg) in combination with nivolumab for adults with unresectable advanced cutaneous melanoma whose disease progressed after prior PD-1–based therapy. Link in the comments 👇

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The Babak Lab @thebabaklab.bsky.social · 25/09/2026

This week came with a very special reason to celebrate! 🎂✨ We got together to wish our wonderful PI, Dr. Masha, a very Happy Birthday! 💙 Thank you for everything you bring to the lab, from your guidance and support to all the science and good moments we share together.

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The Babak Lab @thebabaklab.bsky.social · 23/09/2026

A new study in Cell Chemical Biology explored how the mechanism driving oncogene overexpression can determine the effectiveness of protein degraders such as PROTACs. Link in the comments 👇 #TargetedProteinDegradation #PROTAC #CancerResearch #DrugDiscovery #Oncology

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The Babak Lab @thebabaklab.bsky.social · 21/09/2026

The @fda.gov has approved the first gene therapy for children with Sanfilippo syndrome type A. Link in the comments 👇 #ClinicalMondays #GeneTherapy #SanfilippoSyndrome #Pediatrics #OrphanDrug #FastTrack #BreakthroughTherapy

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The Babak Lab @thebabaklab.bsky.social · 18/09/2026

#LabLife Sharing some experience from 2 days with LARU buddies Alisa Potapova and Kirill Kriukov. Just processed around 75 mice, collecting tumors and organs. A lot of analysis is still ahead, but at least this part is done! #LARU #Research #TeamScience #CancerResearch

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The Babak Lab @thebabaklab.bsky.social · 14/09/2026

The @fda.gov has approved the first therapy for glycogen storage disease type Ia (GSDIa). Genglycos (pariglasgene brecaparvovec-opnr) received accelerated approval for patients aged 8 years and older. Link in the comments 👇 #ClinicalMondays #GeneTherapy #RareDisease #GSDIa #FDA

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The Babak Lab @thebabaklab.bsky.social · 11/09/2026

#LabLife Dasha is sharing flow cytometry life hacks with Alisa and Mira🧪✨ #LabLife #FlowCytometry #Research #TeamScience

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The Babak Lab @thebabaklab.bsky.social · 10/09/2026

Researchers developed ProteinTalks, an AI-based virtual cell model that predicts how cancer cells respond to drugs by tracking changes in their proteins over time. Link in the comments 👇 #ScientificWednesdays #Proteomics #AI #DrugDiscovery #CancerResearch

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The Babak Lab @thebabaklab.bsky.social · 07/09/2026

Merck and Moderna have announced positive top-line results from the Phase 3 INTerpath-001 trial of intismeran autogene (V940) + pembrolizumab in patients with resected high-risk melanoma. Link in the comments 👇 #ClinicalMondays #Melanoma #CancerVaccine #mRNA #Immunotherapy

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The Babak Lab @thebabaklab.bsky.social · 05/09/2026

#LabLife Welcome Mira and Lucy! 🧪✨ 🦠 Mira joins us as a new Research Assistant, with an interest in microbiome-cancer interactions. 🔬 Lucy joins us as our Lab Manager and is interested in forensic pathology. So happy to have you both on the team! 💙

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The Babak Lab @thebabaklab.bsky.social · 02/09/2026

A new @cellpress.bsky.social study analyzed 262 solid tumors across 18 tumor types using spatial transcriptomics and identified conserved, hierarchically organized regions of the tumor microenvironment, termed “spatial groups.” Link in the comments 👇 #CancerResearch

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The Babak Lab @thebabaklab.bsky.social · 31/08/2026

On July 22, the @FDA approved zidesamtinib (Jideytro) for adults with locally advanced or metastatic ROS1-positive non-small cell lung cancer (NSCLC) who have already received at least one ROS1 tyrosine kinase inhibitor (TKI). Link in the comments 👇 #LungCancer #NSCLC #ROS1

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The Babak Lab @thebabaklab.bsky.social · 26/08/2026

A new @nature.com study from the Human Cancer Models Initiative (HCMI) presents a large, deeply characterized collection of next-generation patient-derived cancer models. Link in the comments 👇 #CancerResearch #Organoids #CancerModels

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The Babak Lab @thebabaklab.bsky.social · 25/08/2026

The @fda.gov has approved lutetium Lu 177 vipivotide tetraxetan (Pluvicto) in combination with androgen receptor pathway inhibitor (ARPI) therapy for adults with PSMA-positive metastatic androgen pathway modulation-naïve or-sensitive prostate cancer (mAPMN/S). Link in the comments 👇

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The Babak Lab @thebabaklab.bsky.social · 19/08/2026

Antibody-drug conjugates (ADCs) often face a hard limit: when cancer cells downregulate a target like HER2 or exhibit heterogeneous expression, the treatment stops working. A recent @nature.com study introduces a modular in vivo click chemistry approach to bypass this hurdle Link in the comments 👇

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The Babak Lab @thebabaklab.bsky.social · 17/08/2026

The @fda.gov has approved Tudriqev in combination with nivolumab for adults with unresectable or metastatic cutaneous melanoma that progressed following prior anti-PD-1 therapy. Link in the comments 👇

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The Babak Lab @thebabaklab.bsky.social · 14/08/2026

#LabLife Our wonderful interns have completed their internship! 🎓✨ Thank you for your hard work, curiosity, and great energy. We are so proud of you and wish you lots of success in everything ahead! We’ll miss having you in the lab. 💙 #LabLife #Internship #Research #TeamScience

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The Babak Lab @thebabaklab.bsky.social · 12/08/2026

The tumor microenvironment is not just a mixture of cancer, immune, and stromal cells. Their spatial organization can influence tumor progression and treatment response, but mapping it usually requires complex and expensive technologies. Link in the comments 👇

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The Babak Lab @thebabaklab.bsky.social · 10/08/2026

Despite a turbulent year at the FDA, 46 new therapeutic agents received CDER approval in 2025, keeping the annual number well above the historical average of 36 approvals per year since 1993. Link in the comments 👇

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The Babak Lab @thebabaklab.bsky.social · 07/08/2026

#LabLife Happy Birthday to Nikita Kuznetsov! 🎉 You're a true deep thinker who brings a reflective perspective to our team ❤️and we really appreciate how you help everyone analyse their ideas and propose new experiments using your deep chemistry knowledge 💊

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The Babak Lab @thebabaklab.bsky.social · 05/08/2026

A new @science.org study shows that the time of antigen exposure influences how dendritic cells program CD8⁺ T-cell memory through their intrinsic circadian clock, with important implications for vaccination and immunotherapy. Link in the comments 👇

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The Babak Lab @thebabaklab.bsky.social · 03/08/2026

Can a single CAR T-cell infusion lead to decade-long remission in B-cell lymphoma? A new @nejm.org study reports some of the longest follow-up data available for anti-CD19 CAR T-cell therapy. Link in the comments 👇 #Oncology #CARTcell #CellTherapy

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The Babak Lab @thebabaklab.bsky.social · 01/08/2026

Huge congratulations to Dr. Andy on graduating with his PhD! 🎓 We wish you the absolute best in your next chapter, Dr. Andy!

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The Babak Lab @thebabaklab.bsky.social · 29/07/2026

A recent Nature study reveals that prior chemotherapy and radiation do not simply kill cancer cells — they leave distinct, measurable mutational scars that actively shape tumor evolution at relapse. Link in the comments 👇 #ChildhoodCancer #NatureResearch #CancerGenomics

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The Babak Lab @thebabaklab.bsky.social · 27/07/2026

Can pancreatic cancer be intercepted before it develops? Most pancreatic cancers begin with KRAS mutations, often years before an invasive tumor appears. Link in the comments 👇 #PancreaticCancer #KRAS #CancerVaccines #CancerPrevention #Immunotherapy #ClinicalTrials

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The Babak Lab @thebabaklab.bsky.social · 24/07/2026

#LabLife Lab meetings in progress! A quick hello from our team! We hope you all have a wonderful weekend filled with good company and inspiration. See you next week! ✨

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The Babak Lab @thebabaklab.bsky.social · 23/07/2026

Can ferroptosis make cancer vaccines more effective? A recent study in @nature.com offers a clever workaround: pre-treating tumor cells with ferroptosis before using their lysates to load DCs. Link in the comments 👇 #CancerResearch #Immunotherapy

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The Babak Lab @thebabaklab.bsky.social · 20/07/2026

Is targeted protein degradation ready to compete with established cancer therapies? The latest Phase 3 data suggest the answer may be yes. Results from the SUCCESSOR-2 trial have put mezigdomide in the spotlight. Article link 👇 #MultipleMyeloma #Oncology #ClinicalTrials

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The Babak Lab @thebabaklab.bsky.social · 17/07/2026

#LabLife It was a pleasure meeting Prof. Edmond Kam-lun Lau from Hong Kong Shue Yan University (HKSYU). We are excited to bring together expertise in forensic chemistry and criminal psychology to develop new interdisciplinary teaching and future courses.

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The Babak Lab @thebabaklab.bsky.social · 15/07/2026

The phase 2 POLAR trial, published in @naturemedicine.bsky.social evaluated maintenance pembrolizumab plus olaparib after platinum-based chemotherapy in biomarker-selected metastatic pancreatic cancer. Link in the comments👇 #Oncology #PancreaticCancer #PrecisionOncology #Immunotherapy

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The Babak Lab @thebabaklab.bsky.social · 15/07/2026

We’re hiring! 🧪 The Babak Lab is looking for talented and motivated researchers to join our growing team. If you are passionate about innovative biomedical research and interdisciplinary collaboration, we would love to hear from you. Apply here: thebabaklab.com/opportunities

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The Babak Lab @thebabaklab.bsky.social · 13/07/2026

A phase 3 study published in @thelancet.com evaluated whether adding the gene-mediated cytotoxic immunotherapy combination of CAN-2409 and valacyclovir to standard radiotherapy could reduce this risk. Link in the comments👇 #Oncology #ProstateCancer #GeneTherapy #Radiotherapy

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The Babak Lab @thebabaklab.bsky.social · 08/07/2026

A new study published in @nature.com explores a new strategy for one of the most difficult colorectal cancer subtypes: BRAF-mutant CRC. Link in the comments 👇 #Oncology #ColorectalCancer #BRAF #MolecularGlue #TargetedTherapy #CancerResearch

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The Babak Lab @thebabaklab.bsky.social · 06/07/2026

The @fda.gov has approved Tregzi, an allogeneic regulatory T cell-based immunotherapy with HSPC and T cells, for matched donor HSCT in adults with hematologic malignancies. Link in the comments 👇 #Oncology #Hematology #StemCellTransplant #HSCT #GVHD #CellTherapy #Immunotherapy #CancerResearch

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The Babak Lab @thebabaklab.bsky.social · 03/07/2026

🔬 #LabLife We are happy to start building a collaboration with Tung Wah College, the first and only institution in Hong Kong offering a Bachelor’s programme in Forensic Science. Happy to be friends with you and excited for what we can explore together!

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The Babak Lab @thebabaklab.bsky.social · 29/06/2026

China’s NMPA has approved satricabtagene autoleucel, or satri-cel, for patients with Claudin18.2-positive, HER2-negative advanced gastric or gastroesophageal junction adenocarcinoma after at least two prior lines of therapy. Link in the comments 👇 #Oncology #CART #CellTherapy

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The Babak Lab @thebabaklab.bsky.social · 26/06/2026

🔬 #LabLife We are happy to welcome all our summer students to the lab! Wishing you a productive time and lots of new experiences! Hope you get familiar with the local culture and enjoy exploring Hong Kong ✨ #LabLife #SummerStudents #ResearchTraining #CancerResearch

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The Babak Lab @thebabaklab.bsky.social · 24/06/2026

A new study published in @nature.com presents a strategy for generating CAR T cells directly in vivo, using site-specific genome engineering instead of traditional ex vivo manufacturing. Link in the comments 👇 #Oncology #CART #CellTherapy #Immunotherapy #GenomeEditing

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The Babak Lab @thebabaklab.bsky.social · 22/06/2026

The @fda.gov has approved capivasertib in combination with abiraterone and prednisone for patients with PTEN-deficient metastatic androgen pathway modulation-naïve or -sensitive prostate cancer. Link in the comments 👇 #Oncology #ProstateCancer #PrecisionOncology #AKT #PTEN

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The Babak Lab @thebabaklab.bsky.social · 19/06/2026

This summer, we are excited to welcome a new group of interns to the lab! Meet Celina Xinyue Zhang and from University of Toronto, and Belikov Mikhail from Higher School of Economics. Welcome to the team! 👋 #Internship #SummerInternship #LabLife #CancerResearch

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The Babak Lab @thebabaklab.bsky.social · 17/06/2026

A new study published in @pnas.org explores how extrachromosomal circular DNA, or ecDNA, forms inside cancer cells and helps tumors rapidly adapt under treatment pressure. Link in the comments 👇 #Oncology #CancerResearch #ecDNA #DrugResistance #DNARepair #Glioblastoma

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The Babak Lab @thebabaklab.bsky.social · 15/06/2026

MajesTEC-9 is the first phase 3 study evaluating teclistamab monotherapy versus investigator’s choice of PVd or Kd in patients with relapsed or refractory multiple myeloma after 1–3 prior lines of therapy, including anti-CD38 and lenalidomide exposure. Link in the comments 👇 #Oncology

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The Babak Lab @thebabaklab.bsky.social · 13/06/2026

Sharing some beautiful views from Hong Kong 🇭🇰 📍 Plover Cove Reservoir Dam 📍 Hong Kong Science Park #LabLife #HongKong #ResearchLife

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The Babak Lab @thebabaklab.bsky.social · 10/06/2026

A new study published in @nature.com introduces prodrug-tethered lipid nanoparticles, or pLNPs, designed to co-deliver IL-12 mRNA and an IDO inhibitor prodrug directly into the tumor microenvironment. Link in the comments 👇 #Oncology #Nanomedicine #mRNA #Immunotherapy #LNP

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The Babak Lab @thebabaklab.bsky.social · 09/06/2026

A few weeks ago, we covered the phase 1/2 RMC-6236-001 study, where daraxonrasib showed promising activity in previously treated pancreatic cancer. Now, the phase 3 RASolute 302 trial confirms those early signals in a randomized study. Link in the comments👇 #Oncology #RAS

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The Babak Lab @thebabaklab.bsky.social · 06/06/2026

LARU buddies checking in! 👋 Just Kirill and Alisa sending a quick hello. Have a great weekend, everyone! 🐭💼 #LARU #lablife #researchbuddies #invivo

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The Babak Lab @thebabaklab.bsky.social · 03/06/2026

A new study published in Cancer Discovery reports the preclinical and early clinical activity of RNK08954, a highly selective and orally bioavailable KRASG12D inhibitor designed to target one of the most common KRAS mutations across solid tumors. Link in the comments 👇 #KRAS #CancerResearch

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The Babak Lab @thebabaklab.bsky.social · 01/06/2026

The @US_FDA has approved durvalumab (Imfinzi) in combination with Bacillus Calmette-Guerin (BCG) for adult patients with BCG-naïve, high-risk non-muscle invasive bladder cancer (NMIBC). Link in the comments 👇 #Oncology #BladderCancer #Immunotherapy #Durvalumab

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The Babak Lab @thebabaklab.bsky.social · 29/05/2026

Warm welcome at the University of Palermo! 🇮🇹 Special thanks to all colleagues for making this symposium so inspiring and memorable. #AntiCancer #DrugSymposium #LabLife #CancerResearch #MetalBasedDrugs #UniversityOfPalermo

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