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Tom Longden

@talongden.bsky.social

255 followers 150 following 6 posts

Neurovascular physiologist | Assistant Professor at the University of Maryland Baltimore | Avid sci-fi nerd

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Tom Longden @talongden.bsky.social · 22/07/2026

Thrilled to be co-organizing the 2027 FASEB Science Research Conference on Vasoregulation: Signaling & Multicellular Inputs, with Scott Earley and Madeline Nieves-Cintrón. Save the date for Washington DC, Aug 29–Sep 1. Registration details to follow very soon. Please circulate widely!

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Tom Longden @talongden.bsky.social · 09/06/2026

Very happy to share our latest work out in PNAS this week, led by Amy Xiang. We show that capillary thin-strand pericytes express TMEM16A calcium-activated chloride channels, which set the operating point for capillary control of cerebral blood flow in vivo. www.pnas.org/doi/10.1073/...

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Tom Longden @talongden.bsky.social · 08/04/2025

Thanks for highlighting it Baptiste! Hope it is useful!!

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Reposted by Tom Longden

Amreen Mughal @amreenmughal.bsky.social · 11/12/2024

New publication Alert: Delighted to share our latest work. We describe a unique relationship between electrical and Calcium signaling; 'Electro-Calcium Coupling' in brain capillary endothelial cells. www.pnas.org/doi/10.1073/...

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Tom Longden @talongden.bsky.social · 10/12/2024

Congrats guys! Looking sharp also

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Tom Longden @talongden.bsky.social · 04/12/2024

Thanks all! Super fun project and hopefully useful for the field 😀

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Tom Longden @talongden.bsky.social · 04/12/2024

I am delighted to share the work of my amazing student Dominic Isaacs! Out today in PNAS (www.pnas.org/doi/10.1073/...), Dom beautifully used optogenetics to show that thin-strand pericytes in the brain can send long-range electrical signals to control arteriole diameter and brain blood flow.

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Hanieh Falahati @haniehfalahati.bsky.social · 02/12/2024

Our paper is out just in time for #EM_Monday! It is about a specialized neuron-specific ER, called the spine apparatus, which is found close to synapses and has a very peculiar shape. If you think neurons are special, the spine apparatus is their🦄 horn! But how does it form?! doi.org/10.1016/j.cu...

Gif showing a spine containing spine apparatus, reconstructed from FIB-SEM images. ER: red, synapse: yellow, plasma membrane: blue

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Alexis Rohou @alexisrohou.bsky.social · 02/12/2024

Oh my. This is just gorgeous from Misha Kudryashev's lab (I don't think he's here yet?). Love to see it. V ATPase resolved directly in synaptic vesicles 🤤 Lots of other neat observations in there also. Congrats to all involved! www.pnas.org/doi/10.1073/...

Section through the 3D cryoET map of V-ATPase embedded in synaptic vesicle membrane at 17 Å resolution, as published in PNAS recently.

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Baptiste Lacoste @blacoste.bsky.social · 29/11/2024

www.biorxiv.org/content/10.1...

biorxiv.org

L-Type Ca2+ channels and TRPC3 channels shape brain pericyte Ca2+ signaling and hemodynamics throughout the arteriole to capillary network in vivo

Pericytes play a crucial role in regulating cerebral blood flow (CBF) through processes like vasomotion and neurovascular coupling (NVC). Recent work has identified different pericyte types at distinc...

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